DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Pvr and F59F5.3

DIOPT Version :9

Sequence 1:	NP_001162911.1	Gene:	Pvr / 34127	FlyBaseID:	FBgn0032006	Length:	1577	Species:	Drosophila melanogaster
Sequence 2:	NP_509765.2	Gene:	F59F5.3 / 186634	WormBaseID:	WBGene00010342	Length:	681	Species:	Caenorhabditis elegans

Alignment Length:	763	Identity:	146/763 - (19%)
Similarity:	245/763 - (32%)	Gaps:	280/763 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly   643 LTKAHVLLGNISENMTIYGFDKDHKIAKED--NVNFTCEALAYHFDGNLKWFINGEDLKESDSVH 705
            :.|.|:.:|. .:||    |.|:..::|.:  .|...|.. :||.: |:|...|.:.|
Worm   129 IMKFHMFVGR-DDNM----FFKNTIVSKLNGTGVYLQCSG-SYHTE-NVKLLENQKSL------- 179

  Fly   706 IETSHTKYSYKSTVHITTISDRDRGTYECRAYHNDKDAVYSSREIDLYVHDPSAPQWTNGGQEGH 770
                ...|:.....:|....:.....|:|.  |||:...:..:.:            .|.|.|..
Worm   180 ----DIPYNPFKGFYIDISRNPINRFYQCE--HNDELISFKLQNM------------ANNGYENK 226

  Fly   771 SKIKRKLSQTL--ELECASTAVPVAIVRWFKDDKEVTESKLRHII---------------EKESK 818
            .|:... |.|.  |::|..            ||:.:..:.:..|:               .:.|.
Worm   227 FKMLMN-SYTFQSEIQCVF------------DDQAIKNTHVSVILACPSKSKCPELTNRANRRSH 278

  Fly   819 LLITHLYPGDEGV----YKCVVENRLDRIERSFTVVISDLPGISMAWVWFGVILFLILIGLCVFL 879
            .:.|...|....:    |.||:      |....||..:.|.....:..::.  |.:|..||.:.:
Worm   279 KIYTAFVPKSSNIDPKSYHCVL------IINGNTVAEAFLEEADFSTTYYA--LLIIGAGLILTI 335

  Fly   880 AVRYQKEHKRHLALKAAGLANFEEGAVGHINPDLTLDEQAELLPYNREFEFPRENLKLGKQLGAG 944
            .|...|..:::                 :.|...|.|.:          |...|.|....:||.|
Worm   336 FVILTKSLRQN-----------------NYNKVSTTDVR----------ETRIEELNNKSKLGVG 373

  Fly   945 AFGVVLKGEAKGIRREEPTTTVAVKMVKATADNEVVRA--LVSELKIMVHLGQHLNVVNLLGAVT 1007
            ....:...|             ..|..|.....|.||.  ...|||::..| :|.|::..||.:.
Worm   374 NSSTIYTAE-------------ICKTKKCIVIKESVRKSHCTKELKLLKSL-KHPNIITPLGVIV 424

  Fly  1008 KNIAKRELMVIVEYCRFGNIQNFLLRNRKCFINQINPDTDHIDPSIMTQRMSDNYELHRDTNGGG 1072
            :.                       ..:.||..||.   .|:......:...:.|
Worm   425 QP-----------------------EQKTCFNVQIR---QHLLLPYYQKTCLETY---------- 453

  Fly  1073 LKYANVGFPIHSYINEPHNNNTQPPTHRRNSDNDPRSGTRAGRTGSGTATYSYDRQMDTCATVMT 1137
                     ||.:         .||         .|.|.....|..                  .
Worm   454 ---------IHKF---------YPP---------KRGGNNIFHTNE------------------A 473

  Fly  1138 TVPEDDQIMSNNSVQPAWRSNYKTDSTEAMTVTTVDLISWAFQVARGMDYLSSKKVLHGDLAARN 1202
            ||||::                         :|..||:|.|:|||..::||...::.|.|:|.||
Worm   474 TVPEEE-------------------------ITMFDLVSIAWQVASALEYLKGMEITHRDVAMRN 513

  Fly  1203 ILLCEDNVVKICDFGLARSMYRGDNYKKSENGKLPIKWLALESLSDHVFSTY------------- 1254
            :|:..:.|.||.||..|:   :|:..:|....| .||.:....:|..:...|
Worm   514 VLISNNKVCKITDFERAK---KGETTRKISIEK-KIKEILKAHMSKDIPKEYPNECLKGVYYYYS 574

  Fly  1255 SDVWSYGIVLWEMFSLAKVP------YPGIDPNQELFNKLNDGYRMEKPKFANQELYEIMLECWR 1313
            |:|:.:|.::..:||..| |      ||.|.|.             ..||    .:|:::::|..
Worm   575 SEVYCFGRLMLCLFSFMK-PCDYGRIYPPIQPE-------------NCPK----AIYDLIVDCIN 621

  Fly  1314 KNPESRPLFAELEKRFANMLGEDVASHYLDLNNPYMQSNIEYMKKQST 1361
            :|.:|||..:..         :||.|..|    .:|..: |::|.:.|
Worm   622 ENRKSRPSISSC---------KDVLSTVL----KHMDHD-EFLKLKQT 655

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pvr	NP_001162911.1	IG	346..432	CDD:214652
		Ig	<363..432	CDD:299845
		Ig	466..533	CDD:299845
		IG_like	672..754	CDD:214653	15/83 (18%)
		Ig	674..739	CDD:143165	12/64 (19%)
		IGc2	779..840	CDD:197706	12/81 (15%)
		PKc_like	927..1332	CDD:304357	85/425 (20%)
		Pkinase_Tyr	935..1329	CDD:285015	83/414 (20%)
F59F5.3	NP_509765.2	Pkinase_Tyr	<413..637	CDD:369480	70/360 (19%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0200
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900