DRSC/TRiP Functional Genomics Resources

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Protein Alignment Pvr and Pdgfra

DIOPT Version :9

Sequence 1:NP_001162911.1 Gene:Pvr / 34127 FlyBaseID:FBgn0032006 Length:1577 Species:Drosophila melanogaster
Sequence 2:NP_001076785.1 Gene:Pdgfra / 18595 MGIID:97530 Length:1089 Species:Mus musculus


Alignment Length:1478 Identity:343/1478 - (23%)
Similarity:548/1478 - (37%) Gaps:535/1478 - (36%)


- Green bases have known domain annotations that are detailed below.


  Fly    47 PLMTPCKSAIILDAQTSTTLKCEDDEPMSWWTSQSQ----YVHVKSFDNTEDPARPFGTSLHLIE 107
            |.:.|.::..|:...:|.:|:|..:..:||....|:    .|.::|.:|.   :..|.|.|.::.
Mouse    28 PSILPNENEKIVQLNSSFSLRCVGESEVSWQHPMSEEDDPNVEIRSEENN---SGLFVTVLEVVN 89

  Fly   108 VTADYVAAYYCVKTSKFSQIAKEEQSDEAMIELVNQGYASSIYVYVNDPDTKLVD---SHNVVTA 169
            .:|.:...|.|        .....|:||:.||      ...||:||.|||...|.   :.::|..
Mouse    90 ASAAHTGWYTC--------YYNHTQTDESEIE------GRHIYIYVPDPDMAFVPLGMTDSLVIV 140

  Fly   170 RQYTDVVIPCKPAMPDTEVLLETSNGEMHSSKSVGRYDPQRGF--TIEIRSIVDGGDYYCRPNPP 232
            .:....:|||:...|:|:|.|. :||.:..:.    ||.::||  |..:      |.|.|     
Mouse   141 EEDDSAIIPCRTTDPETQVTLH-NNGRLVPAS----YDSRQGFNGTFSV------GPYIC----- 189

  Fly   233 FPHNEEEMTSIEVRFIATGLDIPRTQTTNMVYTYAPGVTDGDDEVLTVTNQSTGNLALIRGGDGT 297
                  |.|       ..|    ||..|:....||...|                          
Mouse   190 ------EAT-------VKG----RTFKTSEFNVYALKAT-------------------------- 211

  Fly   298 LSRERARRSPARLAPMNASPSPRPGQDGKPLPKPVIRSSVEHHVFTDTNFTLDCEQSAYV----- 357
                                                         ::.|..:|..|:.|.     
Mouse   212 ---------------------------------------------SELNLEMDARQTVYKAGETI 231

  Fly   358 --------ESVYGMEWFTPSRDENRIFASQSRTDPKTRNSTHQTGRSTLTVLNAQPSDTGLYKCV 414
                    ..|..::|..|....|:...........:....:     ||||..|...|:|.|:|.
Mouse   232 VVTCAVFNNEVVDLQWTYPGEVRNKGITMLEEIKLPSIKLVY-----TLTVPKATVKDSGEYECA 291

  Fly   415 TTDNSNQNVQRATYRIKVLKQ------NESYLNVGEPSGH---YNVQEYANRTIQMTANFEGFPT 470
                    .::||..:|.:|:      .:.::.:....|.   .|:.|.....:::.|    :||
Mouse   292 --------ARQATKEVKEMKRVTISVHEKGFVEIEPTFGQLEAVNLHEVREFVVEVQA----YPT 344

  Fly   471 PSFSWFKPD----------GTEVRQSENNFKILSTELSTMLQVLNAQLQDSGTYVLRGSNSFGVV 525
            |..||.|.:          .|:|::|:      .|...:.|:::.|:.:|||.|.:       :|
Mouse   345 PRISWLKDNLTLIENLTEITTDVQKSQ------ETRYQSKLKLIRAKEEDSGHYTI-------IV 396

  Fly   526 QREYNV--------SVMDAPALKMSDAYVQVGSVARLECTVRSYP-PAI---VTFFFRPCSLEPQ 578
            |.|.:|        :::.|..|.:.|.:...|....:.||....| |.|   :....:.|:.:..
Mouse   397 QNEDDVKSYTFELSTLVPASILDLVDDHHGSGGGQTVRCTAEGTPLPEIDWMICKHIKKCNNDTS 461

  Fly   579 WPTCSVLNQNFS-LPSEQEKYQFQTRPRPGKLSVERIYEVSFLPTEPGI-LTCIAQNIIDGKERR 641
            |   :||..|.| :.:|        .||.|:.:||.  .|||...|..| :.|:|:|        
Mouse   462 W---TVLASNVSNIITE--------LPRRGRSTVEG--RVSFAKVEETIAVRCLAKN-------- 505

  Fly   642 TLTKAHVLLGNISENMTIYGFDKDHKIAKEDNVNFTCEALAYHFDGNLKWFINGEDLKESDSVHI 706
                      |:|                                                    
Mouse   506 ----------NLS---------------------------------------------------- 508

  Fly   707 ETSHTKYSYKSTVHITTISDRDRGTYECRAYHNDKDAVYSSREIDLYVHDPSAPQWTNGGQEGHS 771
                                                                             
Mouse   509 ----------------------------------------------------------------- 508

  Fly   772 KIKRKLSQTLELECASTAVPVAIVRWFKDDKEVTESKLRHIIEKESKLLITHLYPGDEGVYKCVV 836
                                                    ::.:|.||:...|            
Mouse   509 ----------------------------------------VVARELKLVAPTL------------ 521

  Fly   837 ENRLDRIERSFTVVISDLPGISMAWVWFGVILFLILIGLCVFLAVRYQKEHKRHLALKAAGLANF 901
                   ....||..:.|           |:|.::::.|.|.:.:..||..           ...
Mouse   522 -------RSELTVAAAVL-----------VLLVIVIVSLIVLVVIWKQKPR-----------YEI 557

  Fly   902 EEGAVGHINPD----LTLDEQAELLPYNREFEFPRENLKLGKQLGAGAFGVVLKGEAKGIRREEP 962
            ....:..|:||    :.:|...  |||:..:||||:.|.||:.||:||||.|::|.|.|:.|.:|
Mouse   558 RWRVIESISPDGHEYIYVDPMQ--LPYDSRWEFPRDGLVLGRILGSGAFGKVVEGTAYGLSRSQP 620

  Fly   963 TTTVAVKMVKATADNEVVRALVSELKIMVHLGQHLNVVNLLGAVTKNIAKRELMVIVEYCRFGNI 1027
            ...|||||:|.||.:...:||:||||||.|||.|||:||||||.||:   ..:.:|.|||.:|::
Mouse   621 VMKVAVKMLKPTARSSEKQALMSELKIMTHLGPHLNIVNLLGACTKS---GPIYIITEYCFYGDL 682

  Fly  1028 QNFLLRNRKCFINQINPDTDHIDPSIMTQRMSD----NYELHRDTNGGGLKYANVGFPIHSYINE 1088
            .|:|.:||..|::| :|:....|..|.....:|    :|.:        |.:.|.|    .|::.
Mouse   683 VNYLHKNRDSFMSQ-HPEKPKKDLDIFGLNPADESTRSYVI--------LSFENNG----DYMDM 734

  Fly  1089 PHNNNTQ--PPTHRRNSDNDPRSGTRAGRTGSGTATYS------YDRQMDTCATVMTTVPEDDQI 1145
            ...:.||  |...|:.                 .:.||      |||.    |:.......|.::
Mouse   735 KQADTTQYVPMLERKE-----------------VSKYSDIQRSLYDRP----ASYKKKSMLDSEV 778

  Fly  1146 MSNNSVQPAWRSNYKTDSTEAMTVTTVDLISWAFQVARGMDYLSSKKVLHGDLAARNILLCEDNV 1210
                      ::....|.:|.:|:  :||:|:.:||||||::|:||..:|.||||||:||.:..:
Mouse   779 ----------KNLLSDDDSEGLTL--LDLLSFTYQVARGMEFLASKNCVHRDLAARNVLLAQGKI 831

  Fly  1211 VKICDFGLARSMYRGDNYKKSENGKLPIKWLALESLSDHVFSTYSDVWSYGIVLWEMFSLAKVPY 1275
            ||||||||||.:....||....:..||:||:|.||:.|::::|.||||||||:|||:|||...||
Mouse   832 VKICDFGLARDIMHDSNYVSKGSTFLPVKWMAPESIFDNLYTTLSDVWSYGILLWEIFSLGGTPY 896

  Fly  1276 PGIDPNQELFNKLNDGYRMEKPKFANQELYEIMLECWRKNPESRPLFAELEKRFANMLGEDVASH 1340
            ||:..:...:||:..||||.||..|..|:||||::||...||.||.|..|.:...|:|.......
Mouse   897 PGMMVDSTFYNKIKSGYRMAKPDHATSEVYEIMVQCWNSEPEKRPSFYHLSEIVENLLPGQYKKS 961

  Fly  1341 YLDLNNPYMQSNIEYMKKQSTD----YLALM------------GSPDELAPAAPRYVNGHIVPDI 1389
            |..::..:::|:...:.:...|    |:.:.            |..||...:|.   :|:|:|..
Mouse   962 YEKIHLDFLKSDHPAVARMRVDSDNAYIGVTYKNEEDKLKDWEGGLDEQRLSAD---SGYIIPLP 1023

  Fly  1390 RIEELP--DDYMEMSRDSDPDACTAIFSPTRLEGESSDFPDFSSETTF 1435
            .|:.:|  :|..:.:|.|...:            |.|.....||.:||
Mouse  1024 DIDPVPEEEDLGKRNRHSSQTS------------EESAIETGSSSSTF 1059

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
PvrNP_001162911.1 IG 346..432 CDD:214652 19/98 (19%)
Ig <363..432 CDD:299845 14/68 (21%)
Ig 466..533 CDD:299845 20/84 (24%)
IG_like 672..754 CDD:214653 0/81 (0%)
Ig 674..739 CDD:143165 0/64 (0%)
IGc2 779..840 CDD:197706 4/60 (7%)
PKc_like 927..1332 CDD:304357 165/416 (40%)
Pkinase_Tyr 935..1329 CDD:285015 161/405 (40%)
PdgfraNP_001076785.1 Ig_3 28..100 CDD:372822 17/74 (23%)
Ig_PDGFR-alphabeta 228..311 CDD:143269 17/95 (18%)
Ig4_PDGFR 313..413 CDD:143267 24/116 (21%)
Ig_TrkABC_d4 416..497 CDD:143173 24/93 (26%)
PTKc_PDGFR_alpha 555..956 CDD:173653 174/451 (39%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1018..1089 13/54 (24%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 291 1.000 Domainoid score I1523
eggNOG 1 0.900 - - E1_KOG0200
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D126783at33208
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 1 1.000 - - otm43420
orthoMCL 1 0.900 - - OOG6_106773
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R6217
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
76.750

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