DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Pvr and kin-9

DIOPT Version :9

Sequence 1:	NP_001162911.1	Gene:	Pvr / 34127	FlyBaseID:	FBgn0032006	Length:	1577	Species:	Drosophila melanogaster
Sequence 2:	NP_001257058.1	Gene:	kin-9 / 181098	WormBaseID:	WBGene00002195	Length:	585	Species:	Caenorhabditis elegans

Alignment Length:	717	Identity:	165/717 - (23%)
Similarity:	270/717 - (37%)	Gaps:	245/717 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly   661 GFDKDHKIAKEDNVNFTCEALAYHFDGNLKWFINGEDLKESDSVHIETSHTKYSYKSTVHITTIS 725
            |...|.:.|:.:|.|                  ...:|..||..::||            ||.:|
Worm    56 GTQTDFRTARNENDN------------------QNHNLSPSDIRYLET------------ITNLS 90

  Fly   726 DRDRGTYECRAYHNDKDAVYSSREIDLYVHDPSAPQ----WTNGG-QEGHSKIKRKLSQTLELEC 785
            .        :|.:|.|..:.:..|::..:..|...|    |.|.. |:|        |...:...
Worm    91 Q--------QALNNVKSTIDTINEVEPPITSPPRSQYQAPWNNQPYQQG--------SWASQYAP 139

  Fly   786 ASTAVPVAIV------RWFKDDK-----EVTESKLRHIIEKESKLLITHLYPGDEGVYKCVVENR 839
            ..|..|..:|      ...:||.     .....|.||:  ..:.|.....|.||    |...|..
Worm   140 YPTLPPEHLVFHPHKPPHHQDDSLEKNPPPPPHKPRHL--PTTPLYYDPYYGGD----KHSSEGG 198

  Fly   840 LDRIERSFTVVISDLPGISMAWVWFGVILFLILIGLCVFLAVRYQKEHKRHLALKAAGLANFEEG 904
            ::.:.....:      ||.:..:.||:.||:.      |...:.::::|....|......|
Worm   199 VNAVALGLGI------GIPLGIIAFGLALFIF------FWCRKRRRQNKNQFPLPFPKKVN---- 247

  Fly   905 AVGHINPDLTLDEQAELLPYNREFEFPRENLKL--GKQLGAGAFGVVLKGEAKGIRREEPTT--- 964
                 :.:..||..|..:  :..:...|.||::  .|:||:|||..|.||:..|   |.|.:
Worm   248 -----DYETQLDSPAYSI--HDPWLLDRNNLEINYSKKLGSGAFCNVFKGKING---EAPVSQIH 302

  Fly   965 -----------TVAVKMVKATADNEVVRALVSELKIMVHLGQHLNVVNLLGAVTKNIAKRELMVI 1018
                       .|||||:.:.||:......:.|:..|..|..|.::|::||.|..   ::...::
Worm   303 PGQRTQLLRDCPVAVKMLPSFADDAARSDFMQEINFMKSLAYHPHLVSMLGFVAD---RKSPYLL 364

  Fly  1019 VEYCRFGNIQNFLLRNRKCFINQINPDTDHIDPSIMTQRMSDNYELHRDTNGGGLKYANVGFPIH 1083
            ||:|..|::.: ::|||:..|  ||..|::.|                     |||..
Worm   365 VEFCEHGDLLH-MIRNRRQEI--INGPTENPD---------------------GLKIK------- 398

  Fly  1084 SYINEPHNNNTQPPTHRRNSDNDPRSGTRAGRTGSGTATYSYDRQMDTCATVMTTVPEDDQIMSN 1148

Worm   399 ----------------------------------------------------------------- 398

  Fly  1149 NSVQPAWRSNYKTDSTEAMTVTTVDLISWAFQVARGMDYLSSKKVLHGDLAARNILLCEDNVVKI 1213
                                    ||:.:::|::.|::||::...:|.|:||||:|:...|..||
Worm   399 ------------------------DLLMFSWQISNGLEYLNNIGCIHRDIAARNVLVDSANTCKI 439

  Fly  1214 CDFGLAR----SMYRGDNYKKSENGKLPIKWLALESLSDHVFSTYSDVWSYGIVLWEMFSLAKVP 1274
            .||||.|    .:|      .:..|:||:||:|.|||:.:.:|..|||||||::|||:|||.:||
Worm   440 GDFGLCRLTDSLLY------TARGGRLPLKWMAPESLATYEYSYKSDVWSYGVLLWELFSLGEVP 498

  Fly  1275 YPGIDPNQELFNKLNDGYRMEKPKFANQELYEIMLECWRKNPESRPLFAELEKRFANMLGEDVAS 1339
            | |.....||......|.|:.||::..:|:|::|..||::.|:.||.|.:.....|.|| |:...
Worm   499 Y-GEVQTTELLQTHRSGKRLLKPEWCPEEIYDVMRLCWQELPDDRPAFQQTCAVLAQML-ENATE 561

  Fly  1340 HY 1341
            :|
Worm   562 NY 563

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pvr	NP_001162911.1	IG	346..432	CDD:214652
		Ig	<363..432	CDD:299845
		Ig	466..533	CDD:299845
		IG_like	672..754	CDD:214653	14/81 (17%)
		Ig	674..739	CDD:143165	10/64 (16%)
		IGc2	779..840	CDD:197706	14/71 (20%)
		PKc_like	927..1332	CDD:304357	110/424 (26%)
		Pkinase_Tyr	935..1329	CDD:285015	107/413 (26%)
kin-9	NP_001257058.1	SKG6	194..230	CDD:370068	8/47 (17%)
kin-9	NP_001257058.1	PTKc	277..557	CDD:270623	109/413 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910