DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Pvr and kin-30

DIOPT Version :9

Sequence 1:	NP_001162911.1	Gene:	Pvr / 34127	FlyBaseID:	FBgn0032006	Length:	1577	Species:	Drosophila melanogaster
Sequence 2:	NP_506771.3	Gene:	kin-30 / 180032	WormBaseID:	WBGene00002211	Length:	458	Species:	Caenorhabditis elegans

Alignment Length:	533	Identity:	147/533 - (27%)
Similarity:	227/533 - (42%)	Gaps:	151/533 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly   836 VENRLDRIERSFTVVISDLPGISMAWVWFGVILFLILIGLCVFLAVRYQKE-----HKRHLA--- 892
            |||. |..|:...:::.    :..|...:|| |.:|.:.:| ||...|:..     ::|:|.
Worm    16 VENH-DESEKPNLIIVF----LMCALFIYGV-LSIIFVTIC-FLRRIYRSSATKNGNRRYLVQNT 73

  Fly   893 -LKAAGLAN-----------FEEGAVGHINPDLT----LDEQAELLPYNREFEFPRENLKL-GKQ 940
             :||....|           .|..::....|.:|    |:|:||.||||..||...|:|.: .||
Worm    74 YVKAQLDTNSSSSLPVDKEIIETISINEETPIITDYQPLNERAEYLPYNPAFEIHSEHLDVFEKQ 138

  Fly   941 LGAGAFGVVLKGEAKGIRR---EEPTTTVAVKMVKATADNEVVRALVSELKIMVHLGQHLNVVNL 1002
            .|.|.||.|.|...|.|.:   |.....||||....:.|....:.::.|:|:|..:|:|.||:.:
Worm   139 FGQGNFGKVNKALLKLINQKTGEVVRMDVAVKKPADSTDKSQDKLILDEIKLMCAIGKHPNVLAI 203

  Fly  1003 LGAVTKN---IAKRELMVIVEYCRFGNIQNFLLRNRKCFINQINPDTDHIDPSIMTQRMSDNYEL 1064
            :||:||.   |.:...:|:.|:...|::::.|         :..|.|.| |....|
Worm   204 VGAITKQEKVIGREHNLVVTEFVEGGDLRSVL---------KYTPYTFH-DELTST--------- 249

  Fly  1065 HRDTNGGGLKYANVGFPIHSYINEPHNNNTQPPTHRRNSDNDPRSGTRAGRTGSGTATYSYDRQM 1129
              |..||.:.                           |||                   .:|.
Worm   250 --DRTGGQMV---------------------------NSD-------------------IFDE-- 264

  Fly  1130 DTCATVMTTVPEDDQIMSNNSVQPAWRSNYKTDSTEAMTVTTVDLISWAFQVARGMDYLSSKKVL 1194
                                                   ::|.||.|:|:|:|.||:||::|..:
Worm   265 ---------------------------------------LSTSDLYSFAYQIANGMEYLAAKPCV 290

  Fly  1195 HGDLAARNILLCEDNVVKICDFGLARSMYRGDNYKKSEN--GKLPIKWLALESLSDHVFSTYSDV 1257
            |.|||.||:.:..:.:::|.||||||...:...|:...|  ..|||.|||.|..::..|:..:||
Worm   291 HRDLALRNVFVKRNKMIRIGDFGLARHHSKKSYYRMQCNPDTPLPIFWLAPECFNESKFTEMTDV 355

  Fly  1258 WSYGIVLWEMFSLAKVPYPGI--DPNQELFNKLNDGYRMEKPKFANQELYEIMLECWRKNPESRP 1320
            ||||:.|:|:|||.:.||..:  .|:.::.:.|..|||:..|::.|.|:||.||.||..:...||
Worm   356 WSYGVCLFELFSLGESPYKKLHNSPSYDVVHYLKKGYRLSAPRYCNAEIYEFMLYCWNIDATLRP 420

  Fly  1321 LFAELEKRFANML 1333
            .|.|. |.|...|
Worm   421 KFTEC-KDFCKSL 432

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pvr	NP_001162911.1	IG	346..432	CDD:214652
		Ig	<363..432	CDD:299845
		Ig	466..533	CDD:299845
		IG_like	672..754	CDD:214653
		Ig	674..739	CDD:143165
		IGc2	779..840	CDD:197706	3/3 (100%)
		PKc_like	927..1332	CDD:304357	116/415 (28%)
		Pkinase_Tyr	935..1329	CDD:285015	112/404 (28%)
kin-30	NP_506771.3	TyrKc	134..428	CDD:197581	111/402 (28%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0200
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D126783at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.820