DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Pvr and hir-1

DIOPT Version :9

Sequence 1:	NP_001162911.1	Gene:	Pvr / 34127	FlyBaseID:	FBgn0032006	Length:	1577	Species:	Drosophila melanogaster
Sequence 2:	NP_504458.1	Gene:	hir-1 / 178936	WormBaseID:	WBGene00016059	Length:	903	Species:	Caenorhabditis elegans

Alignment Length:	986	Identity:	220/986 - (22%)
Similarity:	361/986 - (36%)	Gaps:	352/986 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly   573 CSLEPQWPTCSVLNQNFSLPSEQEKYQFQTRPRPGKLSVERIYEVSFLPTEPGILTCIAQNIIDG 637
            ||....|.||     |..|..|      :|.|.|..|:::.:..:|:.|....::..|....::.
Worm    65 CSDNTCWSTC-----NGELVPE------KTLPAPTNLTLKGVRGLSWSPVPGAVMYYIGYRTLNS 118

  Fly   638 K----------ERRTL-----------TKAHVLLGNISENMTIYGFDKDHKIAKE---------- 671
            |          |::|:           ::..|.:...||: .|....|:.||:..
Worm   119 KTFTSDDFVITEKQTVDLSTLTNIDPCSELEVAVAAFSED-GIGNESKELKISSPKPTANPKLDL 182

  Fly   672 ---DNVNFTCEALAY------HFDGNLK---WFINGEDLKESDSVHIETS--------------- 709
               ..:|.|..:..|      |.:...|   ||:..:||......|:.:.
Worm   183 LELQYLNTTLVSDFYQANATVHVEFRYKTDPWFLGPDDLDVQPLFHLISCVDPDLSQGIPVPDFD 247

  Fly   710 -HTKYSYKSTVHITTISDRDRGTYECRAYHNDKDAVYSSREIDLYVHDPSAPQWTNGGQEGHSKI 773
             |.|.|..||...:.:.||     :||..:..:..:  |::.:.....||.|.
Worm   248 VHVKNSTISTSIGSDMMDR-----KCRYVYYLQSVM--SKKCNTMTEMPSPPS------------ 293

  Fly   774 KRKLSQTLELEC----------------------------------------AS------TAVPV 792
              ...||:::||                                        ||      |.:||
Worm   294 --SALQTIQVECDIVKNAPCVKVPSYQPPLCGMVENVAFSVLSRDRENLNDPASNLTVNVTFIPV 356

  Fly   793 -----------------AIVRWFKDDKEVTESKLRHIIEKESKLLITHLYPGDEGVYKCVVENRL 840
                             |.....|:::......:.|:|.|||..      .|.:....|:.||
Worm   357 TRNNEMPTLYYIGIFGTASEYHTKEEETFLGVNITHVIGKESSC------TGFDSSGNCLAEN-- 413

  Fly   841 DRIERSFTV--------------VISD-----LPGISMAWVWF------------------GVIL 868
              :.||..:              .:.|     ||.:::....|                  |:|:
Worm   414 --LNRSIVLQGIHPKTLYGLTICAVKDIRNLTLPDVTLDSKSFRAKADRIMLVAHTSNNPVGMII 476

  Fly   869 FLILIGLCVFLAV-----RYQKEHKRHLALKAAGLANFEEGAVGHINPDLTLDEQAELLPYNREF 928
            .:::..|.|.|..     .|.::...::..|      |:...||..|.:..:|... :...|..:
Worm   477 GIVIGSLVVILVAIVVIWFYFRKKSENMKFK------FQMEQVGKNNMNRYIDFPI-MAAKNDIW 534

  Fly   929 EFPRENLKL--GKQLGAGAFGVVLKGEAKG---------------IRREEPTTTVAVKMVKATAD 976
            |..|.||.:  .|:||:||||.|..|:..|               :.|.| ...|||||:...||
Worm   535 EIERRNLIIHNDKKLGSGAFGAVYLGKLIGKSLAHKDANSPLGINLMRAE-NCQVAVKMLPEYAD 598

  Fly   977 NEVVRALVSELKIMVHLGQHLNVVNLLGAVTKNIAKRELMVIVEYCRFGNIQNFLLRNRKCFINQ 1041
            .......:.|:.:|..||.|..:||:|..||::   ..|.::||||..|::..| ||.|..::
Worm   599 EMSKHEFLREIALMKTLGYHERLVNMLACVTES---EPLCLVVEYCDNGDLLKF-LRERCKYM-- 657

  Fly  1042 INPDTDHIDPSIMTQRMSDNYELHRDTNGGGLKYANVGFPIHSYINEPHNNNTQPPTHRRNSDND 1106
                                           :|..::|...|                      |
Worm   658 -------------------------------MKLDDLGINYH----------------------D 669

  Fly  1107 PRSGTRAGRTGSGTATYSYDRQMDTCATVMTTVPEDDQIMSNNSVQPAWRSNYKTDSTEAMTVTT 1171
            |                                ||::              ||.|:    |.||.
Worm   670 P--------------------------------PENE--------------NYDTN----MIVTL 684

  Fly  1172 VDLISWAFQVARGMDYLSSKKVLHGDLAARNILLCEDNVVKICDFGLARSMYRGDNYKKSENGKL 1236
            ..|:.:|.|::.|::|||.|..:|.|:||||:|:.|....||.||||.|.:|...:..||:.|||
Worm   685 KQLLQFAVQISYGLEYLSQKGFVHRDVAARNVLVHEGTACKIGDFGLCRYIYADQSQYKSKGGKL 749

  Fly  1237 PIKWLALESLSDHVFSTYSDVWSYGIVLWEMFSLAKVPYPGIDPNQELFNKLNDGYRMEKPKFAN 1301
            |:||::.|::..:.||..||:||:||:|:|:.:|...||||:.| :::...|..|.|:|||....
Worm   750 PLKWMSPEAIRHYEFSIKSDIWSFGILLFEVITLGGSPYPGMPP-EDVLPFLEGGGRIEKPDNCP 813

  Fly  1302 QELYEIMLECWRKNPESRPLFAELEKRFANMLGEDVASHY----LDLNNPYMQSNIEYMKKQSTD 1362
            :..|::|::||..:|:.|..|:::..:.|..| ||:...|    ||....|.  |::|..::.||
Worm   814 ENFYDVMMQCWNADPDDRIEFSDVRMQLATQL-EDITEDYSYLKLDAAKDYY--NVQYGDEKKTD 875

  Fly  1363 YLALMGSPDEL 1373
            .:.:   |||:
Worm   876 VVII---PDEI 883

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pvr	NP_001162911.1	IG	346..432	CDD:214652
		Ig	<363..432	CDD:299845
		Ig	466..533	CDD:299845
		IG_like	672..754	CDD:214653	20/106 (19%)
		Ig	674..739	CDD:143165	19/89 (21%)
		IGc2	779..840	CDD:197706	20/123 (16%)
		PKc_like	927..1332	CDD:304357	119/421 (28%)
		Pkinase_Tyr	935..1329	CDD:285015	115/410 (28%)
hir-1	NP_504458.1	fn3	85..163	CDD:365830	13/78 (17%)
hir-1	NP_504458.1	PTKc	547..842	CDD:270623	114/405 (28%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910