DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Pvr and kin-16

DIOPT Version :9

Sequence 1:	NP_001162911.1	Gene:	Pvr / 34127	FlyBaseID:	FBgn0032006	Length:	1577	Species:	Drosophila melanogaster
Sequence 2:	NP_496017.1	Gene:	kin-16 / 174499	WormBaseID:	WBGene00002200	Length:	495	Species:	Caenorhabditis elegans

Alignment Length:	530	Identity:	140/530 - (26%)
Similarity:	238/530 - (44%)	Gaps:	137/530 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   862 VWFGVILFLILIGLCVFLAVRYQK----EHKRHLA-------LKAAGLANFEEGAVGHINPDLTL 915
            |:|.|...|:|:....||..|.::    |.::::|       |:..|.|..||      ..:..|
Worm    62 VFFVVYGLLVLLAFIAFLVWRLRRSKTQEKRKNMALMNIYSDLRDTGDAMPEE------LKNRPL 120

  Fly   916 DEQAELLPYNREFEFPRENLKLGKQLGAGAFGVVLKG-----EAKGIRREEPTTTVAVKMVKATA 975
            :::.:.|||.:::|...|||:....||:|.||||.||     ..|....::...|||||......
Worm   121 NDKLDYLPYKKQYEIASENLENKSILGSGNFGVVRKGILKMASPKNEEEKKMRLTVAVKSAANCY 185

  Fly   976 DNEVVRALVSELKIMVHLGQHLNVVNLLGAVTKNIAKRELMVIVEYCRFGNIQNFLLRNRKCFIN 1040
            |......|.:||::|..:|:..||:.|:||||..:.|..|:::.||...|:|:.:|:.:|..|
Worm   186 DISQTSMLAAELRLMCSIGRFPNVLALVGAVTSELRKGRLLIVTEYIDCGDIRKYLIDHRNVF-- 248

  Fly  1041 QINPDTDHIDPSIMTQRMSDNYELHRDTNGGGLKYANVGFPIHSYINEPHNNNTQPPTHRRNSDN 1105
                 .||:        :.|.                         .||.:..|.....|:|
Worm   249 -----QDHL--------IEDK-------------------------TEPDSYLTPISAKRKN--- 272

  Fly  1106 DPRSGTRAGRTGSGTATYSYDRQMDTCATVMTTVPEDDQIMSNNSVQPAWRSNYKTDSTEAMTVT 1170
                                        .|.....|:...:...|:.               ::|
Worm   273 ----------------------------YVFKNTDENSDYVIKESLD---------------SLT 294

  Fly  1171 TVDLISWAFQVARGMDYLSSKKVLHGDLAARNILLCEDNVVKICDFGLARSMYRGDNY--KKSEN 1233
            |.||:|:..|:|.||.||:|..::|.|||.||:||.::..::|.|||:||:......|  :|:::
Worm   295 TSDLLSFGLQIANGMQYLASIPMVHRDLALRNVLLKKNKTIRIADFGMARTHENKSYYIPQKTKD 359

  Fly  1234 GKLPIKWLALESLSDHVFSTYSDVWSYGIVLWEMFSLAKVPYPGIDPNQELFNKLNDGYRMEKPK 1298
            ..:|::|::.|:.....|:..|||||:||.|:|:|:|.::|||.: |::.::..::.|.|..:|:
Worm   360 APVPVRWMSPEAFDTMKFTEKSDVWSFGICLYEIFTLGQLPYPDV-PSERIYEYMHSGRRCPQPQ 423

  Fly  1299 FANQELYEIMLECWRKNPESRPLFAELEKRFANMLGEDVASHYLDLNNPYMQSNIEYMKKQSTDY 1363
            ..:.|||::|..||.:.||.||.|:...:.|                       |.:|||.::
Worm   424 HCHVELYDLMKLCWHEKPELRPNFSNCVEYF-----------------------IGHMKKSAS-- 463

  Fly  1364 LALMGSPDEL 1373
             .|:.:.||:
Worm   464 -KLLENVDEM 472

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pvr	NP_001162911.1	IG	346..432	CDD:214652
		Ig	<363..432	CDD:299845
		Ig	466..533	CDD:299845
		IG_like	672..754	CDD:214653
		Ig	674..739	CDD:143165
		IGc2	779..840	CDD:197706
		PKc_like	927..1332	CDD:304357	114/411 (28%)
		Pkinase_Tyr	935..1329	CDD:285015	110/400 (28%)
kin-16	NP_496017.1	STYKc	140..454	CDD:214568	110/400 (28%)
kin-16	NP_496017.1	PTKc	145..454	CDD:270623	109/395 (28%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0200
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D126783at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR24416
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.920