DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Pvr and B0252.1

DIOPT Version :9

Sequence 1:	NP_001162911.1	Gene:	Pvr / 34127	FlyBaseID:	FBgn0032006	Length:	1577	Species:	Drosophila melanogaster
Sequence 2:	NP_495419.2	Gene:	B0252.1 / 174133	WormBaseID:	WBGene00015087	Length:	809	Species:	Caenorhabditis elegans

Alignment Length:	675	Identity:	138/675 - (20%)
Similarity:	230/675 - (34%)	Gaps:	254/675 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly   882 RYQKEHKRHLALK-AAGLANFEEGA---VGHINPDLTLDEQAELLPYNREFEFPRENLKLGKQLG 942
            |.|.|:.:.|||. |..|...||.|   |...:.::.|.....:...||:||||..
Worm   174 RNQNENTQRLALSYADDLTPLEEAAEFPVFKSDDEMNLSATRNIFQENRDFEFPAI--------- 229

  Fly   943 AGAFGVVLKGEAKGIRREEPTTTVAV-----------KMVKATADNEVVRALVSELKI---MVH- 992
                          |..::|::.|.|           ::|::|.:....:  :|:.|:   .||
Worm   230 --------------IHEDKPSSDVYVFMTSFNVSQLMRVVESTINGPTCQ--MSQTKMYSQFVHS 278

  Fly   993 ---------------LGQ--HLNVVNLLG-----AVTKNIAKRELMV---IVEYCRFGNIQNF-- 1030
                           |||  |....|.|.     |...|....:..:   .||:....|.|.|
Worm   279 QIIKNGTVWQIILPWLGQKTHSFSSNCLKSFNHMAAEPNCTAMKAQIYANFVEHVAAANNQTFCY 343

  Fly  1031 -LLRNRKC-----FINQINPDTDHIDPSIMTQRMSDNYE--------------------LHRD-- 1067
             .:.|.:|     ....|. |:.|| ..:|.:.::|.||                    :|.|
Worm   344 LFVGNAECATTTNLTTNIK-DSTHI-RLVMDEDLNDVYEDFTLPLVNLGFLDKTVDNQVIHNDMF 406

  Fly  1068 ---------TNGGGL------------KYANV-------------------GFPIHSYINEPHNN 1092
                     |:...:            ||.::                   |..|:.:::..|..
Worm   407 YLQNYSTSCTDEIPMVPLLSARPWHRPKYLSIALDDMLTIFICATISVTTFGILIYRHVSRKHRQ 471

  Fly  1093 NT--------QPPTHRRNSDNDPRSGTRAGR-----------------TGSGTATYSY------- 1125
            ..        ||..::.     |:...:..|                 .|.||.:..|
Worm   472 QVELLSELMLQPRIYKA-----PKECAKVARLPWEIKSENVHIDKEFLLGEGTISNVYLGKLKGK 531

  Fly  1126 -------DR----QMDTCATVMTT-----VPEDDQIM------------SNNSVQPAWRSNYKTD 1162
                   ||    |...||..:..     .||:||:.            .:.::...|.:  |.|
Worm   532 SPIMQWIDRVEMKQYQDCAVAVRVPSHFDEPEEDQLQREIASMRQLRHHDHIALLLGWTN--KND 594

  Fly  1163 ST-EAMTVTTVDLISW------------------------------AFQVARGMDYLSSKKVLHG 1196
            .. ..:.:|.::||.:                              .:::..|::|:.|:.::|.
Worm   595 LVCSLLELTHMNLIKYLSQIRETAEQDNSSGFTPMSRIPFQVLYKIIYEICDGIEYIHSRNLVHR 659

  Fly  1197 DLAARNILLCEDNVVKICDFGLARSMYRGDNYKKSENG----KLPIKWLALESLSDHVFSTYSDV 1257
            ||.|||:||......||..||...   ..|:.|.:.|.    .||::|||.|..... ||..||.
Worm   660 DLTARNVLLTTGLRAKISGFGFCS---EPDDPKFAANSLALRYLPVRWLAPECFIGK-FSVKSDS 720

  Fly  1258 WSYGIVLWEMFSLAKVPYPGIDPNQELFNKLNDGYRMEKPKFANQELYEIMLECWRKNPESRPLF 1322
            ||:|::::|||||.:.||..:...:|:...:..|.....||:.:::.|:||..|::.....||.|
Worm   721 WSFGVLMYEMFSLGEQPYEDLIRPEEIIESIRKGRVPAHPKYCSKQTYKIMQSCYQSFMSRRPNF 785

  Fly  1323 AELEKRFANMLGEDVASHYLDLNNP 1347
            .:|:..|     ...:::|  .|||
Worm   786 TQLKNAF-----HVQSTNY--YNNP 803

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pvr	NP_001162911.1	IG	346..432	CDD:214652
		Ig	<363..432	CDD:299845
		Ig	466..533	CDD:299845
		IG_like	672..754	CDD:214653
		Ig	674..739	CDD:143165
		IGc2	779..840	CDD:197706
		PKc_like	927..1332	CDD:304357	119/609 (20%)
		Pkinase_Tyr	935..1329	CDD:285015	114/598 (19%)
B0252.1	NP_495419.2	PKc_like	515..792	CDD:389743	69/282 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0200
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900