DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Pvr and Kdr

DIOPT Version :9

Sequence 1:NP_001162911.1 Gene:Pvr / 34127 FlyBaseID:FBgn0032006 Length:1577 Species:Drosophila melanogaster
Sequence 2:NP_034742.2 Gene:Kdr / 16542 MGIID:96683 Length:1345 Species:Mus musculus


Alignment Length:1577 Identity:386/1577 - (24%)
Similarity:628/1577 - (39%) Gaps:444/1577 - (28%)


- Green bases have known domain annotations that are detailed below.


  Fly    47 PLMTPCKSAIILDAQTSTTLKCEDDEPMSW-WTSQSQYVHVKSFDNTE----------DPARPFG 100
            |.::..|..:.:.|.|:..:.|.....:.| |.:..:       |:.|          |..  |.
Mouse    32 PKLSTQKDILTILANTTLQITCRGQRDLDWLWPNAQR-------DSEERVLVTECGGGDSI--FC 87

  Fly   101 TSLHLIEVTADYVAAYYCVKTSKFSQIAKEEQSDEAMIELVNQGYASSIYVYVNDPDTKLV---- 161
            .:|.:..|..:...||.|    .:..:                ..||::||||.|..:..:    
Mouse    88 KTLTIPRVVGNDTGAYKC----SYRDV----------------DIASTVYVYVRDYRSPFIASVS 132

  Fly   162 DSHNVV--TARQYTDVVIPCKPAMPDTEVLLETSNGEMHSSKSVGR--YDPQRGFTIEIRSIVDG 222
            |.|.:|  |..:...|||||:.::.:..|.|.....|........|  :|.:.|||:....|...
Mouse   133 DQHGIVYITENKNKTVVIPCRGSISNLNVSLCARYPEKRFVPDGNRISWDSEIGFTLPSYMISYA 197

  Fly   223 GDYYCRPNPPFPHNEEEMTSIEVRFIATGLDIPRTQTTNMVYTYAPGVTDGDDEVLTVTNQSTGN 287
            |..:|...    .|:|...||....:..|.   |.....:...:...::.|:..||..|.::..|
Mouse   198 GMVFCEAK----INDETYQSIMYIVVVVGY---RIYDVILSPPHEIELSAGEKLVLNCTARTELN 255

  Fly   288 LALIRGGDGTLSRERARRSPARLAPMNASPSPRPGQDGKPLPKPVIRSSVEHHVFTDTNFTLDCE 352
            :.|    |.|.      .||    |..:.......:|.||.|..|.:..:               
Mouse   256 VGL----DFTW------HSP----PSKSHHKKIVNRDVKPFPGTVAKMFL--------------- 291

  Fly   353 QSAYVESVYGMEWFTPSRDENRIFASQSRTDPKTRNSTHQTGRSTLTVLNAQPSDTGLYKCVTTD 417
                                                       ||||:.:...||.|.|.||.:.
Mouse   292 -------------------------------------------STLTIESVTKSDQGEYTCVASS 313

  Fly   418 NSNQNVQRATYRIKVLKQNESYLNV-GEP-----SGHYN-VQEYANRTIQMTANFEGFPTPSFSW 475
            .            :::|:|.:::.| .:|     ||..: |:......:::...:..:|.|...|
Mouse   314 G------------RMIKRNRTFVRVHTKPFIAFGSGMKSLVEATVGSQVRIPVKYLSYPAPDIKW 366

  Fly   476 FKPDGTEVRQSENNFKILSTELSTMLQVLNAQLQDSGTYVLRGSNSFGVVQREYNVS-VMDAP-- 537
            :: :|   |..|:|:.::..:..|:::|..   :|:|.|.:..:|...:.::.:.|| |::.|  
Mouse   367 YR-NG---RPIESNYTMIVGDELTIMEVTE---RDAGNYTVILTNPISMEKQSHMVSLVVNVPPQ 424

  Fly   538 -----ALKMSDAYVQVGSVARLECTVRSYPPAIVTFFFRPCSLEPQW-----PTCSVLNQNFSLP 592
                 .:...|:| |.|::..|.|||.:.||.          ...||     ..||.        
Mouse   425 IGEKALISPMDSY-QYGTMQTLTCTVYANPPL----------HHIQWYWQLEEACSY-------- 470

  Fly   593 SEQEKYQFQTRPRPGKLSVERIYEVSFLPT-EPGILTCIAQN---IIDGKERRTLTKAHVLLGNI 653
                        |||:.|.....|...:.. :.|....:.:|   :|:|| .:|::...:...|:
Mouse   471 ------------RPGQTSPYACKEWRHVEDFQGGNKIEVTKNQYALIEGK-NKTVSTLVIQAANV 522

  Fly   654 SENMTIYGFDKDHKIAK-------------------------EDNVNFTCEALAYHFDGNLKWFI 693
            |   .:|..:..:|..:                         :::|:..|.|....|: ||.|:.
Mouse   523 S---ALYKCEAINKAGRGERVISFHVIRGPEITVQPAAQPTEQESVSLLCTADRNTFE-NLTWYK 583

  Fly   694 NGEDLKESDSVHIETSHTK--------YSYKSTVHITTISD-----------RDRGTYECRAYHN 739
            .|   .::.|||:..|.|.        :....|:...:.:|           :|:|.|.|.|   
Mouse   584 LG---SQATSVHMGESLTPVCKNLDALWKLNGTMFSNSTNDILIVAFQNASLQDQGDYVCSA--- 642

  Fly   740 DKDAVYSSREI---DLYVHDPSAPQWTNGGQEGHSKIKRKLSQTLELECASTAVPVAIVRWFKDD 801
             :|.....|..   .|.:.:..||..| |..|..:   ..:.:|:|:.|.::..|...:.||||:
Mouse   643 -QDKKTKKRHCLVKQLIILERMAPMIT-GNLENQT---TTIGETIEVTCPASGNPTPHITWFKDN 702

  Fly   802 KEVTESKLRHIIEKESKLLITHLYPGDEGVYKCVVENRLD--RIERSF-----------TVVISD 853
            :.:.|.....:.:....|.|..:...|.|:|.|...|.|.  |.|..|           .|:|  
Mouse   703 ETLVEDSGIVLRDGNRNLTIRRVRKEDGGLYTCQACNVLGCARAETLFIIEGAQEKTNLEVII-- 765

  Fly   854 LPGISMAWVWFGVILFLILIGLCVFLAVRYQKEHKRHLALKAAGLANFEEGAVGHI----NPD-L 913
            |.|.::..::|.::|.::|            :..||         ||..|...|::    :|| |
Mouse   766 LVGTAVIAMFFWLLLVIVL------------RTVKR---------ANEGELKTGYLSIVMDPDEL 809

  Fly   914 TLDEQAELLPYN-REFEFPRENLKLGKQLGAGAFGVVLKGEAKGIRREEPTTTVAVKMVKATADN 977
            .|||:.|.|||: .::||||:.|||||.||.||||.|::.:|.||.:.....||||||:|..|.:
Mouse   810 PLDERCERLPYDASKWEFPRDRLKLGKPLGRGAFGQVIEADAFGIDKTATCKTVAVKMLKEGATH 874

  Fly   978 EVVRALVSELKIMVHLGQHLNVVNLLGAVTKNIAKRELMVIVEYCRFGNIQNFLLRNRKCFINQI 1042
            ...|||:|||||::|:|.||||||||||.||  ....||||||:|:|||:..:|...|..|:   
Mouse   875 SEHRALMSELKILIHIGHHLNVVNLLGACTK--PGGPLMVIVEFCKFGNLSTYLRGKRNEFV--- 934

  Fly  1043 NPDTDHIDPSIMTQRMSDNYELHRDTNGGGLKYANVGFPIHSYINEPHNNNTQPPTHRRNSDNDP 1107
                                           .|.:.|                            
Mouse   935 -------------------------------PYKSKG---------------------------- 940

  Fly  1108 RSGTRAGRTGSGTATYSYDRQMDTCATVMTTVPE---DDQIMSNNSVQPAWRSNYKTDSTEAMTV 1169
             :..|.|:...|..:....|::|:..:..::...   :::.:|:...:.|....||.      .:
Mouse   941 -ARFRQGKDYVGELSVDLKRRLDSITSSQSSASSGFVEEKSLSDVEEEEASEELYKD------FL 998

  Fly  1170 TTVDLISWAFQVARGMDYLSSKKVLHGDLAARNILLCEDNVVKICDFGLARSMYRGDNYKKSENG 1234
            |...||.::||||:||::|:|:|.:|.|||||||||.|.||||||||||||.:|:..:|.:..:.
Mouse   999 TLEHLICYSFQVAKGMEFLASRKCIHRDLAARNILLSEKNVVKICDFGLARDIYKDPDYVRKGDA 1063

  Fly  1235 KLPIKWLALESLSDHVFSTYSDVWSYGIVLWEMFSLAKVPYPGIDPNQELFNKLNDGYRMEKPKF 1299
            :||:||:|.|::.|.|::..|||||:|::|||:|||...||||:..::|...:|.:|.||..|.:
Mouse  1064 RLPLKWMAPETIFDRVYTIQSDVWSFGVLLWEIFSLGASPYPGVKIDEEFCRRLKEGTRMRAPDY 1128

  Fly  1300 ANQELYEIMLECWRKNPESRPLFAELEKRFANMLGEDVASHYLDLNNPYMQSNIEYMKKQSTDYL 1364
            ...|:|:.||:||.::|..||.|:||.:...|:|                |:|.:   :...||:
Mouse  1129 TTPEMYQTMLDCWHEDPNQRPSFSELVEHLGNLL----------------QANAQ---QDGKDYI 1174

  Fly  1365 AL-------MGSPDELA-PAAPRYVNGHIVPDIRIEELPD------------DYMEMSRDSDPDA 1409
            .|       |.....|: |.:|       |..:..||:.|            .|::.|:......
Mouse  1175 VLPMSETLSMEEDSGLSLPTSP-------VSCMEEEEVCDPKFHYDNTAGISHYLQNSKRKSRPV 1232

  Fly  1410 CTAIFSPTRL-EGESSDFPDFSSETTFNFPGARQSPTLSNNLNSGSSKPLRKKNGMPTVDVADQA 1473
            ....|....| |.|....||.|...:.....:.:..||.:.     :|......||         
Mouse  1233 SVKTFEDIPLEEPEVKVIPDDSQTDSGMVLASEELKTLEDR-----NKLSPSFGGM--------- 1283

  Fly  1474 PEEIPMLHRSSTGSDGS 1490
               :|...|.|..|:||
Mouse  1284 ---MPSKSRESVASEGS 1297

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
PvrNP_001162911.1 IG 346..432 CDD:214652 10/85 (12%)
Ig <363..432 CDD:299845 10/68 (15%)
Ig 466..533 CDD:299845 15/67 (22%)
IG_like 672..754 CDD:214653 23/103 (22%)
Ig 674..739 CDD:143165 20/83 (24%)
IGc2 779..840 CDD:197706 16/60 (27%)
PKc_like 927..1332 CDD:304357 152/407 (37%)
Pkinase_Tyr 935..1329 CDD:285015 148/396 (37%)
KdrNP_034742.2 Ig_3 31..105 CDD:404760 15/81 (19%)
Ig 226..327 CDD:416386 28/184 (15%)
Ig strand A 226..230 CDD:409353 0/3 (0%)
Ig strand A' 236..240 CDD:409353 0/3 (0%)
Ig strand B 242..251 CDD:409353 3/8 (38%)
Ig strand C 258..263 CDD:409353 3/14 (21%)
Ig strand C' 266..268 CDD:409353 1/1 (100%)
Ig strand D 272..280 CDD:409353 1/7 (14%)
Ig strand E 288..296 CDD:409353 3/65 (5%)
Ig strand F 306..312 CDD:409353 3/5 (60%)
Ig strand G 317..323 CDD:409353 2/5 (40%)
Ig 331..419 CDD:416386 18/94 (19%)
Ig strand A 331..334 CDD:409353 0/2 (0%)
Ig strand A' 341..345 CDD:409353 1/3 (33%)
Ig strand B 347..358 CDD:409353 0/10 (0%)
Ig strand C 362..368 CDD:409353 2/5 (40%)
Ig strand C' 370..373 CDD:409353 2/5 (40%)
Ig strand D 378..381 CDD:409353 0/2 (0%)
Ig strand E 383..388 CDD:409353 1/4 (25%)
Ig strand F 396..404 CDD:409353 2/7 (29%)
Ig strand G 410..419 CDD:409353 2/8 (25%)
Ig_3 549..643 CDD:404760 20/101 (20%)
I-set 665..742 CDD:400151 20/80 (25%)
Ig strand B 682..686 CDD:409353 1/3 (33%)
Ig strand C 695..699 CDD:409353 0/3 (0%)
Ig strand E 718..722 CDD:409353 1/3 (33%)
Ig strand F 732..737 CDD:409353 2/4 (50%)
VEGFR-2_TMD 757..791 CDD:375470 9/56 (16%)
PTKc_VEGFR2 824..1165 CDD:270681 155/427 (36%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1272..1316 9/43 (21%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 291 1.000 Domainoid score I1523
eggNOG 1 0.900 - - E1_KOG0200
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 417 1.000 Inparanoid score I1795
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D126783at33208
OrthoFinder 1 1.000 - - FOG0001573
OrthoInspector 1 1.000 - - otm43420
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 1 1.000 - - X787
SwiftOrtho 1 1.000 - -
TreeFam 1 0.960 - -
1110.830

Return to query results.
Submit another query.