DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Pvr and Flt4

DIOPT Version :9

Sequence 1:NP_001162911.1 Gene:Pvr / 34127 FlyBaseID:FBgn0032006 Length:1577 Species:Drosophila melanogaster
Sequence 2:NP_032055.1 Gene:Flt4 / 14257 MGIID:95561 Length:1363 Species:Mus musculus


Alignment Length:1592 Identity:390/1592 - (24%)
Similarity:625/1592 - (39%) Gaps:425/1592 - (26%)


- Green bases have known domain annotations that are detailed below.


  Fly    41 GGENG----APLMTPCKSAIILDAQTSTTLKCEDDEPMSWWTSQSQYVHVKSFDNTED------- 94
            |..||    .|.:...:.:.::|...|.::.|....|:.|....:|.|......::||       
Mouse    20 GLANGYSMTPPTLNITEDSYVIDTGDSLSISCRGQHPLEWTWPGAQEVLTTGGKDSEDTRVVHDC 84

  Fly    95 ---PARPFGTSLHLIEVTADYVAAYYCVKTSKFSQIAKEEQSDEAMIELVNQGYASSIYVYVND- 155
               .|||:...|.|.:..|:...:|:|.    :..|       :|.||...   |:|.||:|.| 
Mouse    85 EGTEARPYCKVLLLAQTHANNTGSYHCY----YKYI-------KARIEGTT---AASTYVFVRDF 135

  Fly   156 -------PDTKLVDSHNVVTARQYTDVVIPCKPAMPDTEVLLETSNGEMHSSKSVGRYDPQRGFT 213
                   |||.||:..:        .:.:||..::|...:.|.:.:..:|.......:|.:||..
Mouse   136 KHPFINKPDTLLVNRKD--------SMWVPCLVSIPGLNITLRSQSSALHPDGQEVLWDDRRGMR 192

  Fly   214 IEIRSIVDGGDYYCRPNPPFPHNEEEMTSIEVRFIATGLDIPRTQTTNMVYTYAPGVTDGDDEVL 278
            :..:.:.|.....|.                                         .|.||...|
Mouse   193 VPTQLLRDALYLQCE-----------------------------------------TTWGDQNFL 216

  Fly   279 TVTNQSTGNLALIRGGDGTLSRERARRSPARLAPMNASPSPRPGQDGKPLPKPVIRSSVEHHVFT 343
            :       ||.::......|                        .|.:..||    .|:|  :..
Mouse   217 S-------NLFVVHITGNEL------------------------YDIQLYPK----KSME--LLV 244

  Fly   344 DTNFTLDCEQSAYVESVYGMEWFTPSRDENRIFASQSRTDPKTRN-STHQTGRSTLTVLNAQPSD 407
            .....|:|...|..:|....:|..|.:.     |.:::..|:.|: .||....|.||:.|...:|
Mouse   245 GEKLVLNCTVWAEFDSGVTFDWDYPGKQ-----AERAKWVPERRSQQTHTELSSILTIHNVSQND 304

  Fly   408 TGLYKCVTTDNSNQNVQRATYRIKVLKQNESYLNVGEPSGHYNVQEYANRTIQMTANFEGFPTPS 472
            .|.|.|    .:|..:||.....:|:...:.:::|....|........:..:::......:|.|.
Mouse   305 LGPYVC----EANNGIQRFRESTEVIVHEKPFISVEWLKGPVLEATAGDELVKLPVKLAAYPPPE 365

  Fly   473 FSWFKPDGTEVRQSENNFKILSTELSTMLQVLNAQLQDSGTYVLRGSNSFGVVQREYNVS---VM 534
            |.|:| |...|....|...::..|::.         ..:|.|.|...||...:::  |:|   |:
Mouse   366 FQWYK-DRKAVTGRHNPHALVLKEVTE---------ASAGVYTLALWNSAAGLRQ--NISLELVV 418

  Fly   535 DAP-----ALKMSDAYVQVGSVARLECTVRSYP-PAIVTFFFRPCSLEPQWPTCSVLNQNFSLPS 593
            :.|     ....|.:.....|...|.||....| |..|.:.:||      |..|....|......
Mouse   419 NVPPHIHEKEASSPSIYSRHSRQTLTCTAYGVPQPLSVQWHWRP------WTPCKTFAQRSLRRR 477

  Fly   594 EQEKYQFQTRPRPGKLSVERIYEVSFLP--TEPGILTCIAQNIIDGKERRTLTKAHVLLGNIS-- 654
            :|.....|.|......:.:.:..:..|.  ||          .::|| .:|::|..:...|:|  
Mouse   478 QQRDGMPQCRDWKEVTTQDAVNPIESLDSWTE----------FVEGK-NKTVSKLVIQDANVSAM 531

  Fly   655 -----------ENMTIY--------GFDKDHKIAKE----DNVNFTCEALAYHFDGNLKWF-ING 695
                       :...||        ||..:.:.:::    .:|..:|.|..|.:: :|:|: :|.
Mouse   532 YKCVVVNKVGQDERLIYFYVTTIPDGFSIESEPSEDPLEGQSVRLSCRADNYTYE-HLRWYRLNL 595

  Fly   696 EDLKESD---------SVHIETSHTKYSYKS----------TVHITTISDRDRGTYECRAYHNDK 741
            ..|.::.         :||:..:..:.:.:.          :::|..::..|.|.|.|.      
Mouse   596 STLHDAQGNPLLLDCKNVHLFATPLEANLEEAEPGARHATLSLNIPRVAPEDEGDYVCE------ 654

  Fly   742 DAVYSSREIDLYVHDP-------SAPQWTNGGQEGHSKIKRKLSQTLELECASTAVPVAIVRWFK 799
              |...|..|.:.|..       .||:.|    :..:.:...:|.:||:.|......|..:.|:|
Mouse   655 --VQDRRSQDKHCHKKYLSVQALEAPRLT----QNLTDLLVNVSDSLEMRCPVAGAHVPSIVWYK 713

  Fly   800 DDKEVTESKLRHIIEKES---------KLLITHLYPGDEGVYKCVVENRLDRIERSFTVVISD-- 853
            |::         ::||||         :|.|..:...|.|.|.|.|.|....:..|.:|.:..  
Mouse   714 DER---------LLEKESGIDLADSNQRLSIQRVREEDAGRYLCSVCNAKGCVNSSASVAVEGSE 769

  Fly   854 ---------LPGISMAWVWFGVILFLILIGLCVFLAVRYQKEHKRHLALKAAGLANFEEGAVGHI 909
                     |.|..:..|:|.|:|.||...:          :...|..:|...|:..       :
Mouse   770 DKGSMEIVILIGTGVIAVFFWVLLLLIFCNM----------KRPAHADIKTGYLSII-------M 817

  Fly   910 NP-DLTLDEQAELLPYN-REFEFPRENLKLGKQLGAGAFGVVLKGEAKGIRREEPTTTVAVKMVK 972
            :| ::.|:||.|.|.|: .::|||||.|.||:.||.||||.|::..|.||.:.....||||||:|
Mouse   818 DPGEVPLEEQCEYLSYDASQWEFPRERLHLGRVLGHGAFGKVVEASAFGINKGSSCDTVAVKMLK 882

  Fly   973 ATADNEVVRALVSELKIMVHLGQHLNVVNLLGAVTKNIAKRELMVIVEYCRFGNIQNFLLRNRKC 1037
            ..|.....|||:|||||::|:|.||||||||||.||  ....||||||:|::||:.|||...|..
Mouse   883 EGATASEHRALMSELKILIHIGNHLNVVNLLGACTK--PNGPLMVIVEFCKYGNLSNFLRVKRDT 945

  Fly  1038 FINQINPDTDHIDPSIMTQRMSDNYELHRDTNGGGLKYANVGFPIHSYINEPHNNNTQPPTHRRN 1102
            |    ||                              ||.                 :.|..||.
Mouse   946 F----NP------------------------------YAE-----------------KSPEQRRR 959

  Fly  1103 SDNDPRS---GTRAGRTGSGTATYSYDRQMDTCATVMTTVPEDDQIMSNNSVQPA---------W 1155
            .    |:   |.:|.|...|    |.||.:.|           ..:|...|.:.|         |
Mouse   960 F----RAMVEGAKADRRRPG----SSDRALFT-----------RFLMGKGSARRAPLVQEAEDLW 1005

  Fly  1156 RSNYKTDSTEAMTVTTVDLISWAFQVARGMDYLSSKKVLHGDLAARNILLCEDNVVKICDFGLAR 1220
            .|          .:|..||:.::|||||||::|:|:|.:|.|||||||||.|.::||||||||||
Mouse  1006 LS----------PLTMEDLVCYSFQVARGMEFLASRKCIHRDLAARNILLSESDIVKICDFGLAR 1060

  Fly  1221 SMYRGDNYKKSENGKLPIKWLALESLSDHVFSTYSDVWSYGIVLWEMFSLAKVPYPGIDPNQELF 1285
            .:|:..:|.:..:.:||:||:|.||:.|.|::|.|||||:|::|||:|||...||||:..|:|..
Mouse  1061 DIYKDPDYVRKGSARLPLKWMAPESIFDKVYTTQSDVWSFGVLLWEIFSLGASPYPGVQINEEFC 1125

  Fly  1286 NKLNDGYRMEKPKFANQELYEIMLECWRKNPESRPLFAELEKRFANML----GEDVASHYLDLNN 1346
            .:|.||.||..|:.|...:..||..||..:|::||.|::|.:...::|    .::.....:.|::
Mouse  1126 QRLKDGTRMRAPELATPAIRHIMQSCWSGDPKARPAFSDLVEILGDLLQGGGWQEEEEERMALHS 1190

  Fly  1347 PYMQSNIEYMKKQSTDYLALMGSPDELAPA------APRYVN-----GHIVPDIR---------I 1391
            ........:|:..:|.........|:..|:      |.||.|     |.:....:         .
Mouse  1191 SQSSEEDGFMQASTTALHITEADADDSPPSMHCHSLAARYYNCVSFPGRLARGTKTPGSSRMKTF 1255

  Fly  1392 EELP--DDYMEMSRDSDPDACTAIFSPTRLEGESSDFPD--FSSE---TTFNFP-------GARQ 1442
            ||||  ....:.|.|:..|:...:.|....|.||...|:  ||.:   ...:.|       |.|:
Mouse  1256 EELPMTPTTYKASMDNQTDSGMVLASEEFEELESRHRPEGSFSCKGPGQHMDIPRGHPDPQGRRR 1320

  Fly  1443 SPT--------LSNNLNSGSSKPLRKKNGMPT 1466
            .||        ..||.....|:|..:.:..|:
Mouse  1321 RPTQGAQGGKVFYNNEYGEVSQPCTEGDCCPS 1352

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
PvrNP_001162911.1 IG 346..432 CDD:214652 22/86 (26%)
Ig <363..432 CDD:299845 18/69 (26%)
Ig 466..533 CDD:299845 16/69 (23%)
IG_like 672..754 CDD:214653 18/101 (18%)
Ig 674..739 CDD:143165 15/84 (18%)
IGc2 779..840 CDD:197706 19/69 (28%)
PKc_like 927..1332 CDD:304357 163/416 (39%)
Pkinase_Tyr 935..1329 CDD:285015 158/405 (39%)
Flt4NP_032055.1 IG_like 238..327 CDD:214653 25/99 (25%)
Ig1_VEGFR 245..329 CDD:143270 23/92 (25%)
IG_like 341..415 CDD:214653 16/85 (19%)
Ig 352..418 CDD:299845 16/77 (21%)
Ig 569..662 CDD:299845 17/101 (17%)
IG 570..663 CDD:214652 17/101 (17%)
I-set 678..765 CDD:254352 24/99 (24%)
IGc2 693..755 CDD:197706 19/70 (27%)
PKc_like 837..1175 CDD:304357 164/419 (39%)
Pkinase_Tyr 845..1169 CDD:285015 158/405 (39%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1288..1330 10/41 (24%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 291 1.000 Domainoid score I1523
eggNOG 1 0.900 - - E1_KOG0200
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 417 1.000 Inparanoid score I1795
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D126783at33208
OrthoFinder 1 1.000 - - FOG0001573
OrthoInspector 1 1.000 - - otm43420
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 1 1.000 - - X787
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
109.830

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