DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Pvr and Flt3

DIOPT Version :9

Sequence 1:NP_001162911.1 Gene:Pvr / 34127 FlyBaseID:FBgn0032006 Length:1577 Species:Drosophila melanogaster
Sequence 2:NP_034359.2 Gene:Flt3 / 14255 MGIID:95559 Length:1000 Species:Mus musculus


Alignment Length:1197 Identity:287/1197 - (23%)
Similarity:443/1197 - (37%) Gaps:388/1197 - (32%)


- Green bases have known domain annotations that are detailed below.


  Fly   279 TVTNQSTGNLALIRGGDGTLSRERARRSPARLAPMNASPSPRPGQDGKPLPKPVIRSSVEHHVFT 343
            |||||....:..:     .:|.|.           |.|.:      |||....::|.|.|     
Mouse    25 TVTNQDLPVIKCV-----LISHEN-----------NGSSA------GKPSSYRMVRGSPE----- 62

  Fly   344 DTNFTLDCEQSAYVESVYGMEWFTPSR-DENRIFASQSRTDPKTRNSTHQTGRSTLTVLNAQPSD 407
                .|.|               .|.| .|..::.:.:       ....::|..||.|..|.|.|
Mouse    63 ----DLQC---------------APRRQSEGTVYEAAT-------VEVAESGSITLQVQLATPGD 101

  Fly   408 TGLYKCVTT------------DNSNQNVQRATYRIKVLKQNESYLNVGE-PSGHY--NVQ-EYAN 456
               ..|:..            |..|:.:           .:.:.|||.| .:|.|  ::| |.||
Mouse   102 ---LSCLWVFKHSSLGCQPHFDLQNRGI-----------VSMAILNVTETQAGEYLLHIQSEAAN 152

  Fly   457 RTIQMTANF--------------------------EGFPTPSFSWF---------KPDGTEVRQS 486
            .|:..|.|.                          ||.|.|:..|.         |.:|..|.:.
Mouse   153 YTVLFTVNVRDTQLYVLRRPYFRKMENQDALLCISEGVPEPTVEWVLCSSHRESCKEEGPAVVRK 217

  Fly   487 ENNFKILSTELSTMLQVLNAQLQDSGTYVLRGSNSFGVVQRE----YNVSVMDAPALKMSDAYVQ 547
            |.  |:|.....|.::..             ..|:.|   ||    :.:.:..||...:...:::
Mouse   218 EE--KVLHELFGTDIRCC-------------ARNALG---RECTKLFTIDLNQAPQSTLPQLFLK 264

  Fly   548 VGSVARLECTVRSYPPAIVTFFFRPCSLEPQWPTCSVL--NQNFSLPSEQEKYQFQTRPRPGKLS 610
            ||                          ||.|..|..:  |..|.|..|.|         ...|.
Mouse   265 VG--------------------------EPLWIRCKAIHVNHGFGLTWELE---------DKALE 294

  Fly   611 VERIYEVSFLPTEPGILTCIAQNIIDGKERRTLTKAHVLLGNISENMTIYGFDKDHKIAKEDNVN 675
            ....:|:|...|                 .||:.:  :||..:|            .:.:.|...
Mouse   295 EGSYFEMSTYST-----------------NRTMIR--ILLAFVS------------SVGRNDTGY 328

  Fly   676 FTCEALAYHFDGNL-----KWFINGEDLKESDSVHIETSHTKY----SYKSTVHITTISDRDRGT 731
            :||.:..:.....|     |.|||....:|...:   ..:.|:    .:|:...|.......:.:
Mouse   329 YTCSSSKHPSQSALVTILEKGFINATSSQEEYEI---DPYEKFCFSVRFKAYPRIRCTWIFSQAS 390

  Fly   732 YECR------AY-------HNDKDAVYSSREIDLYVHDPSAPQWTNGGQEGHSKIKRKLSQTL-- 781
            :.|.      .|       |.:|...|.     .|..:..| |:|    :..:...||..|.|  
Mouse   391 FPCEQRGLEDGYSISKFCDHKNKPGEYI-----FYAENDDA-QFT----KMFTLNIRKKPQVLAN 445

  Fly   782 ----ELECASTAVPVAIVRWFK-DDK--EVTESKLRHIIEKESKLLI-------THLYPGDEG-- 830
                :..|:|...|:....|.| .||  ..||.....:..|::...:       :.|...:.|  
Mouse   446 ASASQASCSSDGYPLPSWTWKKCSDKSPNCTEEIPEGVWNKKANRKVFGQWVSSSTLNMSEAGKG 510

  Fly   831 -VYKCVVENRLDRIERSFTVVISDLPG--------ISMAWVWFGVILFLILIGLCV-FLAV---- 881
             :.||...|.:.   .|...:..:.||        ||          |...||||: |:.|    
Mouse   511 LLVKCCAYNSMG---TSCETIFLNSPGPFPFIQDNIS----------FYATIGLCLPFIVVLIVL 562

  Fly   882 ---RYQKEHKRHLALKAAGLANFEEGAVGHINPDLTLDEQAELL-----PYNREFEFPRENLKLG 938
               :|:|:.:....|:...:..             .||.:...:     .|:.::|||||||:.|
Mouse   563 ICHKYKKQFRYESQLQMIQVTG-------------PLDNEYFYVDFRDYEYDLKWEFPRENLEFG 614

  Fly   939 KQLGAGAFGVVLKGEAKGIRREEPTTTVAVKMVKATADNEVVRALVSELKIMVHLGQHLNVVNLL 1003
            |.||:||||.|:...|.||.:...:..|||||:|..||:....||:||||:|.|||.|.|:||||
Mouse   615 KVLGSGAFGRVMNATAYGISKTGVSIQVAVKMLKEKADSCEKEALMSELKMMTHLGHHDNIVNLL 679

  Fly  1004 GAVTKNIAKRELMVIVEYCRFGNIQNFLLRNRKCFINQINPDTDHIDPSIMTQRMSDNYELHRDT 1068
            ||.|   ....:.:|.|||.:|::.|:|...|:.|                          ||  
Mouse   680 GACT---LSGPVYLIFEYCCYGDLLNYLRSKREKF--------------------------HR-- 713

  Fly  1069 NGGGLKYANVGFPIHSYINEP----HNNNTQPPTHRRNSDNDPRSGTRAGRTGSGTATYSYDRQM 1129
                 .:..: |..|::...|    |:|::.|.:  |.....|.....:|..|:           
Mouse   714 -----TWTEI-FKEHNFSFYPTFQAHSNSSMPGS--REVQLHPPLDQLSGFNGN----------- 759

  Fly  1130 DTCATVMTTVPEDDQIMSNNSVQPAWRSNYKTDSTEAMTVTTVDLISWAFQVARGMDYLSSKKVL 1194
                    .:..:|:|...|..:.|     :.:..:...:|..||:.:|:|||:||::|..|..:
Mouse   760 --------LIHSEDEIEYENQKRLA-----EEEEEDLNVLTFEDLLCFAYQVAKGMEFLEFKSCV 811

  Fly  1195 HGDLAARNILLCEDNVVKICDFGLARSMYRGDNYKKSENGKLPIKWLALESLSDHVFSTYSDVWS 1259
            |.||||||:|:....|||||||||||.:....:|....|.:||:||:|.|||.:.:::..|||||
Mouse   812 HRDLAARNVLVTHGKVVKICDFGLARDILSDSSYVVRGNARLPVKWMAPESLFEGIYTIKSDVWS 876

  Fly  1260 YGIVLWEMFSLAKVPYPGIDPNQELFNKLNDGYRMEKPKFANQELYEIMLECWRKNPESRPLF-- 1322
            |||:|||:|||...|||||..:...:..:..|::||:|.:|.:.:|.:|..||..:...||.|  
Mouse   877 YGILLWEIFSLGVNPYPGIPVDANFYKLIQSGFKMEQPFYATEGIYFVMQSCWAFDSRKRPSFPN 941

  Fly  1323 ---------AELEKRFANMLGEDVASH 1340
                     ||.|:.....:|.:|..|
Mouse   942 LTSFLGCQLAEAEEAMYQNMGGNVPEH 968

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
PvrNP_001162911.1 IG 346..432 CDD:214652 15/98 (15%)
Ig <363..432 CDD:299845 13/81 (16%)
Ig 466..533 CDD:299845 16/79 (20%)
IG_like 672..754 CDD:214653 17/103 (17%)
Ig 674..739 CDD:143165 13/86 (15%)
IGc2 779..840 CDD:197706 17/79 (22%)
PKc_like 927..1332 CDD:304357 145/419 (35%)
Pkinase_Tyr 935..1329 CDD:285015 139/408 (34%)
Flt3NP_034359.2 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 45..67 9/51 (18%)
ig 256..346 CDD:278476 24/155 (15%)
PKc_like 573..950 CDD:304357 146/452 (32%)
Important for normal regulation of the kinase activity and for maintaining the kinase in an inactive state in the absence of ligand binding. /evidence=ECO:0000250 592..598 0/5 (0%)
Pkinase_Tyr 611..946 CDD:285015 136/397 (34%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 968..1000 1/1 (100%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 291 1.000 Domainoid score I1523
eggNOG 1 0.900 - - E1_KOG0200
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 1 1.000 - - otm43420
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
43.810

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