DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Pvr and Fgfr3

DIOPT Version :9

Sequence 1:	NP_001162911.1	Gene:	Pvr / 34127	FlyBaseID:	FBgn0032006	Length:	1577	Species:	Drosophila melanogaster
Sequence 2:	NP_001156689.1	Gene:	Fgfr3 / 14184	MGIID:	95524	Length:	802	Species:	Mus musculus

Alignment Length:	982	Identity:	258/982 - (26%)
Similarity:	384/982 - (39%)	Gaps:	331/982 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly   444 EPSGHYNVQEYANRTIQMTANFE-GFPTPSFSWFKPDGTEVRQSENNFKILSTELSTMLQVLNAQ 507
            |||....|...:..|::::.:.. |.||....|.| |||.:..|.   :||..  ...||||||.
Mouse    40 EPSQQEQVAFGSGDTVELSCHPPGGAPTGPTVWAK-DGTGLVASH---RILVG--PQRLQVLNAS 98

  Fly   508 LQDSGTYVLRGSNSFGVVQR---EYNVSVMDAPAL----KMSDAYVQVGSVARLECTVRSYPPAI 565
            .:|:|.|    |....:.:|   .::|.|.|||:.    ...|.....|:
Mouse    99 HEDAGVY----SCQHRLTRRVLCHFSVRVTDAPSSGDDEDGEDVAEDTGA--------------- 144

  Fly   566 VTFFFRPCSLEPQWPTCSVLNQNFSLPSEQEKYQFQTRPRPGKLSVERIYEVSFLPTEPGILTCI 630
                       |.|                      |||       ||:
Mouse   145 -----------PYW----------------------TRP-------ERM---------------- 153

  Fly   631 AQNIIDGKERRTLTKAHVLLGNISENMTIYGFDKDHKIAKEDNVNFTCEALAYHFDGN----LKW 691
                    :::.|.                       :...:.|.|.|.|.     ||    :.|
Mouse   154 --------DKKLLA-----------------------VPAANTVRFRCPAA-----GNPTPSISW 182

  Fly   692 FINGEDLKESDSV-HIETSHTKYSYKSTVHITTISDRDRGTYECRAYHNDKDAVYSSREIDLYVH 755
            ..||::.:....: .|:..|.::|    :.:.::...|||.|.| ...|...::..:..:|:...
Mouse   183 LKNGKEFRGEHRIGGIKLRHQQWS----LVMESVVPSDRGNYTC-VVENKFGSIRQTYTLDVLER 242

  Fly   756 DPSAPQWTNGGQEGHSKIKRKLSQTLELECA--STAVPVAIVRWFKDDKEVTESK---------- 808
            .|..|....|.....:.|   |...:|..|.  |.|.|  .::|.| ..||..||
Mouse   243 SPHRPILQAGLPANQTAI---LGSDVEFHCKVYSDAQP--HIQWLK-HVEVNGSKVGPDGTPYVT 301

  Fly   809 -----LRHIIEKESKLLITHLYPGDEGVYKCVVENRLDRIERSFTVVI------------SDLPG 856
                 :...:|.:::|.:.::...|.|.|.|...|.:...|::|.:.:            :|..|
Mouse   302 VLKSWISENVEADARLRLANVSERDGGEYLCRATNFIGVAEKAFWLRVHGPQAAEEELMETDEAG 366

  Fly   857 ISMAWVW-FGVILFLILIGLCVFLAVRYQKE----------H-------KRHLALKAAGLANFE- 902
            ...|.|. :||:.||.::.:...:..|.:..          |       ||.::|::....|..
Mouse   367 SVYAGVLSYGVVFFLFILVVAAVILCRLRSPPKKGLGSPTVHKVSRFPLKRQVSLESNSSMNSNT 431

  Fly   903 -----------EGAVGHINPDLTLDEQAEL-LPYNREFEFPRENLKLGKQLGAGAFGVVLKGEAK 955
                       ||.|        |...:|| ||.:.::|..|..|.|||.||.|.||.|:..||.
Mouse   432 PLVRIARLSSGEGPV--------LANVSELELPADPKWELSRTRLTLGKPLGEGCFGQVVMAEAI 488

  Fly   956 GIRREEPT--TTVAVKMVKATADNEVVRALVSELKIMVHLGQHLNVVNLLGAVTKNIAKRELMVI 1018
            ||.::...  .||||||:|..|.::.:..||||:::|..:|:|.|::|||||.|:.   ..|.|:
Mouse   489 GIDKDRTAKPVTVAVKMLKDDATDKDLSDLVSEMEMMKMIGKHKNIINLLGACTQG---GPLYVL 550

  Fly  1019 VEYCRFGNIQNFLLRNRKCFINQINPDTDHIDPSIMTQRMSDNYELHRDTNGGGLKYANVGFPIH 1083
            |||...||::.||...|
Mouse   551 VEYAAKGNLREFLRARR------------------------------------------------ 567

  Fly  1084 SYINEPHNNNTQPPTHRRNSDNDPRSGTRAGRTGSGTATYSYDRQMDTCATVMTTVPEDDQIMSN 1148
                        ||                          ..|...|.|     .:||:.
Mouse   568 ------------PP--------------------------GMDYSFDAC-----RLPEEQ----- 584

  Fly  1149 NSVQPAWRSNYKTDSTEAMTVTTVDLISWAFQVARGMDYLSSKKVLHGDLAARNILLCEDNVVKI 1213
                                :|..||:|.|:||||||:||:|:|.:|.||||||:|:.||||:||
Mouse   585 --------------------LTCKDLVSCAYQVARGMEYLASQKCIHRDLAARNVLVTEDNVMKI 629

  Fly  1214 CDFGLARSMYRGDNYKKSENGKLPIKWLALESLSDHVFSTYSDVWSYGIVLWEMFSLAKVPYPGI 1278
            .||||||.::..|.|||:.||:||:||:|.|:|.|.|::..|||||:|::|||:|:|...|||||
Mouse   630 ADFGLARDVHNLDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLLWEIFTLGGSPYPGI 694

  Fly  1279 DPNQELFNKLNDGYRMEKPKFANQELYEIMLECWRKNPESRPLFAELEKRFANMLGEDVASHYLD 1343
             |.:|||..|.:|:||:||.....:||.||.|||...|..||.|.:|.:....:|.......|||
Mouse   695 -PVEELFKLLKEGHRMDKPASCTHDLYMIMRECWHAVPSQRPTFKQLVEDLDRILTVTSTDEYLD 758

  Fly  1344 LNNPYMQ 1350
            |:.|:.|
Mouse   759 LSVPFEQ 765

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pvr	NP_001162911.1	IG	346..432	CDD:214652
		Ig	<363..432	CDD:299845
		Ig	466..533	CDD:299845	23/70 (33%)
		IG_like	672..754	CDD:214653	19/86 (22%)
		Ig	674..739	CDD:143165	17/69 (25%)
		IGc2	779..840	CDD:197706	18/77 (23%)
		PKc_like	927..1332	CDD:304357	143/406 (35%)
		Pkinase_Tyr	935..1329	CDD:285015	141/395 (36%)
Fgfr3	NP_001156689.1	IGc2	51..110	CDD:197706	22/68 (32%)
		IG	52..108	CDD:214652	22/65 (34%)
		Ig2_FGFR	155..239	CDD:143265	19/116 (16%)
		IG_like	254..349	CDD:214653	22/100 (22%)
		Ig3_FGFR	262..350	CDD:143175	20/90 (22%)
		PTKc_FGFR3	455..788	CDD:173652	152/431 (35%)
		Pkinase_Tyr	468..744	CDD:285015	141/395 (36%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910