Protein Alignment Pvr and Fgfr1

DIOPT Version :10

• Sequence 1: NP_001162911.1
• Gene: Pvr / 34127
• FlyBaseID: FBgn0032006
• Length: 1577
• Species: Drosophila melanogaster
• Sequence 2: NP_034336.2
• Gene: Fgfr1 / 14182
• MGIID: 95522
• Length: 822
• Species: Mus musculus
• Alignment Length: 890
• Identity: 228/890 - (25%)
• Similarity: 344/890 - (38%)
• Gaps: 339/890 - (38%)

  Fly   688 NLKWFINGEDLKESDSVHIETSHTKYSYKSTVHITTISDRDRGTYEC---------RAYH--NDK 741
            ::.|..:|..|.||:...|....        |.:......|.|.|.|         ..|.  |..
Mouse    63 SINWLRDGVQLVESNRTRITGEE--------VEVRDSIPADSGLYACVTSSPSGSDTTYFSVNVS 119

  Fly   742 DAVYSSREIDLYVHD------------------PSAPQWTNGGQEGHSKIKRKL-----SQTLEL 783
            ||:.||.:.|   .|                  |.||.||:     ..|:::||     ::|::.
Mouse   120 DALPSSEDDD---DDDDSSSEEKETDNTKPNRRPVAPYWTS-----PEKMEKKLHAVPAAKTVKF 176

  Fly   784 ECASTAVPVAIVRW------FKDDKEVTESKLRHIIEKESKLLITHLYPGDEGVYKCVVEN---- 838
            :|.|:..|...:||      ||.|..:...|:|:   ....:::..:.|.|:|.|.|:|||
Mouse   177 KCPSSGTPNPTLRWLKNGKEFKPDHRIGGYKVRY---ATWSIIMDSVVPSDKGNYTCIVENEYGS 238

  Fly   839 -----RLDRIERS---------------------------------------------------- 846
                 :||.:|||
Mouse   239 INHTYQLDVVERSPHRPILQAGLPANKTVALGSNVEFMCKVYSDPQPHIQWLKHIEVNGSKIGPD 303

  Fly   847 -----------------------------------FTVVISDLPGISMAWVWFGVI--------- 867
                                               :|.:..:..|:|....|..|:
Mouse   304 NLPYVQILKTAGVNTTDKEMEVLHLRNVSFEDAGEYTCLAGNSIGLSHHSAWLTVLEALEERPAV 368

  Fly   868 ----LFLILIGLC--VFL-------AVRYQKE--------------HK--------RHLALKAAG 897
                |:|.:|..|  .||       .:.|:.:              ||        |.:.:.|..
Mouse   369 MTSPLYLEIIIYCTGAFLISCMLGSVIIYKMKSGTKKSDFHSQMAVHKLAKSIPLRRQVTVSADS 433

  Fly   898 LANFEEGAV--------GHINPDLTLDEQAELLPYNREFEFPRENLKLGKQLGAGAFGVVLKGEA 954
            .|:...|.:        ....|.|....:.| ||.:..:|.||:.|.|||.||.|.||.|:..||
Mouse   434 SASMNSGVLLVRPSRLSSSGTPMLAGVSEYE-LPEDPRWELPRDRLVLGKPLGEGCFGQVVLAEA 497

  Fly   955 KGIRREEP--TTTVAVKMVKATADNEVVRALVSELKIMVHLGQHLNVVNLLGAVTKNIAKRELMV 1017
            .|:.:::|  .|.|||||:|:.|..:.:..|:||:::|..:|:|.|::|||||.|::   ..|.|
Mouse   498 IGLDKDKPNRVTKVAVKMLKSDATEKDLSDLISEMEMMKMIGKHKNIINLLGACTQD---GPLYV 559

  Fly  1018 IVEYCRFGNIQNFLLRNRKCFINQINPDTDHIDPSIMTQRMSDNYELHRDTNGGGLKYANVGFPI 1082
            ||||...||::.:|...|.                                  .||:|.
Mouse   560 IVEYASKGNLREYLQARRP----------------------------------PGLEYC------ 584

  Fly  1083 HSYINEPHNNNTQPPTHRRNSDNDPRSGTRAGRTGSGTATYSYDRQMDTCATVMTTVPEDDQIMS 1147
               .|..||                                                ||:.
Mouse   585 ---YNPSHN------------------------------------------------PEEQ---- 594

  Fly  1148 NNSVQPAWRSNYKTDSTEAMTVTTVDLISWAFQVARGMDYLSSKKVLHGDLAARNILLCEDNVVK 1212
                                 :::.||:|.|:||||||:||:|||.:|.||||||:|:.||||:|
Mouse   595 ---------------------LSSKDLVSCAYQVARGMEYLASKKCIHRDLAARNVLVTEDNVMK 638

  Fly  1213 ICDFGLARSMYRGDNYKKSENGKLPIKWLALESLSDHVFSTYSDVWSYGIVLWEMFSLAKVPYPG 1277
            |.||||||.::..|.|||:.||:||:||:|.|:|.|.:::..|||||:|::|||:|:|...||||
Mouse   639 IADFGLARDIHHIDYYKKTTNGRLPVKWMAPEALFDRIYTHQSDVWSFGVLLWEIFTLGGSPYPG 703

  Fly  1278 IDPNQELFNKLNDGYRMEKPKFANQELYEIMLECWRKNPESRPLFAELEKRFANMLGEDVASHYL 1342
            : |.:|||..|.:|:||:||.....|||.:|.:||...|..||.|.:|.:....::.......||
Mouse   704 V-PVEELFKLLKEGHRMDKPSNCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRIVALTSNQEYL 767

  Fly  1343 DLNNPYMQSNIEYMKKQSTDYLALMGS-------PDELAPAAPRY 1380
            ||:.|..|.:..:...:|:...:...|       |:|  |..||:
Mouse   768 DLSIPLDQYSPSFPDTRSSTCSSGEDSVFSHEPLPEE--PCLPRH 810

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Pvr	NP_001162911.1	IG_like	346..432	CDD:214653
		Ig strand C	363..366	CDD:409353
		Ig strand E	396..400	CDD:409353
		Ig strand F	410..415	CDD:409353
		Ig strand G	425..428	CDD:409353
		Ig	458..533	CDD:472250
		Ig strand B	459..463	CDD:409353
		Ig strand C	472..476	CDD:409353
		Ig strand E	497..503	CDD:409353
		Ig strand F	513..518	CDD:409353
		Ig	671..>742	CDD:472250	13/64 (20%)
		Ig strand B	674..678	CDD:409353
		Ig strand C	687..691	CDD:409353	0/2 (0%)
		Ig strand E	717..721	CDD:409353	1/3 (33%)
		Ig strand F	731..736	CDD:409353	2/13 (15%)
		Ig	779..851	CDD:472250	25/173 (14%)
		Ig strand B	781..785	CDD:409570	0/3 (0%)
		Ig strand C	794..798	CDD:409570	2/9 (22%)
		Ig strand E	816..821	CDD:409570	0/4 (0%)
		Ig strand F	831..836	CDD:409570	2/4 (50%)
		Ig strand G	844..847	CDD:409570	3/89 (3%)
		Protein Kinases, catalytic domain	927..1332	CDD:473864	141/406 (35%)
Fgfr1	NP_034336.2	IgI_1_FGFR	25..118	CDD:409362	12/62 (19%)
		Ig strand A	25..28	CDD:409362
		Ig strand A'	40..46	CDD:409362
		Ig strand B	49..59	CDD:409362
		Ig strand C	63..68	CDD:409362	1/4 (25%)
		Ig strand C'	71..73	CDD:409362	0/1 (0%)
		Ig strand D	78..82	CDD:409362	0/3 (0%)
		Ig strand E	85..90	CDD:409362	1/12 (8%)
		Ig strand F	96..105	CDD:409362	3/8 (38%)
		Ig strand G	108..118	CDD:409362	1/9 (11%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	120..162		12/49 (24%)
		IgI_2_FGFR	153..247	CDD:409443	26/101 (26%)
		Ig strand A	153..156	CDD:409443	1/2 (50%)
		Heparin-binding	160..177		4/16 (25%)
		Ig strand A'	164..169	CDD:409443	2/4 (50%)
		Ig strand B	173..181	CDD:409443	2/7 (29%)
		Ig strand C	187..192	CDD:409443	2/4 (50%)
		Ig strand C'	195..197	CDD:409443	0/1 (0%)
		Ig strand D	206..209	CDD:409443	1/2 (50%)
		Ig strand E	213..218	CDD:409443	0/4 (0%)
		Ig strand F	227..234	CDD:409443	3/6 (50%)
		Ig strand G	237..247	CDD:409443	1/9 (11%)
		Ig	255..359	CDD:472250	4/103 (4%)
		Ig strand B	273..277	CDD:409353	0/3 (0%)
		Ig strand C	286..290	CDD:409353	0/3 (0%)
		Ig strand E	324..328	CDD:409353	0/3 (0%)
		Ig strand F	338..343	CDD:409353	1/4 (25%)
		Ig strand G	351..354	CDD:409353	0/2 (0%)
		PTKc_FGFR1	464..765	CDD:270678	144/421 (34%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	782..822		7/31 (23%)