DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Pvr and Flt3

DIOPT Version :9

Sequence 1:	NP_001162911.1	Gene:	Pvr / 34127	FlyBaseID:	FBgn0032006	Length:	1577	Species:	Drosophila melanogaster
Sequence 2:	NP_001094292.1	Gene:	Flt3 / 140635	RGDID:	61308	Length:	1000	Species:	Rattus norvegicus

Alignment Length:	1188	Identity:	280/1188 - (23%)
Similarity:	450/1188 - (37%)	Gaps:	351/1188 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly   279 TVTNQSTGNL---ALIRGGDGTLSRERARRSPARLAPMNASPSPRPGQDGKPLPKPVIRSSVEHH 340
            |||||....:   .:|...:|:.:.:.:.......:|.:...:|:...:|      |:..:|...
  Rat    24 TVTNQDLPVIKCVLIIHKNNGSAAGKSSSHVMVPESPEDLRCAPKHRSEG------VVYEAVTVE 82

  Fly   341 VFTDTNFTLDCEQS---------AYVESVYGMEWFTPSRD-ENRIFASQSRTDPKTRNSTHQTGR 395
            |....:|||..:.:         .:..|..|.:   |..| :||...|
  Rat    83 VAQSASFTLQVQLTTPGDVSCLWVFKHSSLGCQ---PHFDLQNRRIVS----------------- 127

  Fly   396 STLTVLNAQPSDTGLYKC-VTTDNSNQNVQRATYRIKVLKQNESYLNVGEPSGHYNVQEYANRTI 459
              :|:||...:..|.|.. :.::.:|..|   .:.:.| :..:.|: :..||    .::..|:..
  Rat   128 --MTILNVTETQAGEYLLHIQSEATNHTV---LFTVNV-RDTQLYV-LRRPS----FRKMENQDA 181

  Fly   460 QMTANFEGFPTPSFSWF---------KPDGTEVRQSENNFKILSTELSTMLQVLNAQLQDSGTYV 515
            .:..: ||.|.|:..|.         :.:|:.|.:.|.  |:|.....|.::..
  Rat   182 LLCVS-EGVPEPTVEWVVCSSHRDSCREEGSAVVKKEE--KVLHELFETDIRCC----------- 232

  Fly   516 LRGSNSFGVVQRE----YNVSVMDAPALKMSDAYVQVGSVARLECTVRSYPPAIVTFFFRPCSLE 576
              ..|:.|   ||    :.:.:..||...:...:::||                          |
  Rat   233 --ARNALG---RECTKLFTIDLNQAPQSTLPQLFLKVG--------------------------E 266

  Fly   577 PQWPTCSVL--NQNFSLPSE------QEKYQFQTRPRPGKLSVERIYEVSFL------------- 620
            |.|..|..:  |..|.|..|      :|...|:........|:.||. ::|:
  Rat   267 PLWIRCKAIHVNHGFGLTWELGNKVLEEGSYFEMSSYSTNRSMIRIL-LAFVSSVGRNNTGYYTC 330

  Fly   621 -----PTEPGILTCIAQNIIDGKERRTLTKAHVLLGNISENMTIYGFDKDHKIAKEDNVNFTCEA 680
                 |::..::|.:.:..|                |.:.:...|..|...|..      |:...
  Rat   331 SSSKHPSQTALVTILEKGFI----------------NATSSQEEYEIDPYEKFC------FSVRF 373

  Fly   681 LAYHFDGNLKWFINGEDLKESDSVHIETSHTKYSYKSTVHITTISD--RDRGTYECRAYHNDKDA 743
            .||. ....||..:      ..|...|.|..:..|.    |:...|  .:.|.|   .:|.:.|.
  Rat   374 KAYP-QIRCKWTFS------QTSFPCEQSGLEDGYS----ISKFCDHKNNPGEY---IFHGENDD 424

  Fly   744 VYSSREIDLYVHDPSAPQWTNGGQEGHSKIKRKLSQTL------ELECASTAVPVAIVRWFK-DD 801
            ...::...|                   .|:|| .|.|      :..|.|...|:....|.| .|
  Rat   425 AQFTKMFIL-------------------NIRRK-PQVLANASASQASCFSDGYPLPNWTWKKCSD 469

  Fly   802 K--EVTESKLRHIIEKESKLLI-------THLYPGDEG---VYKCVVENRLDRIERSFTVVISDL 854
            |  ..||.....:..|::...:       :.|...:.|   :.||...|.:.   .|...::.:.
  Rat   470 KSPNCTEEIPEGVWNKKANRKVFGQWVSSSTLNMSEAGRGFLVKCCAYNSMG---TSCETILLNS 531

  Fly   855 PG--------ISMAWVWFGVILFLILIGLC--------VFLAVRYQKEHKRHLALKAAGLANFEE 903
            ||        ||          |...||||        |.:..:|:|:.:....|:...:..
  Rat   532 PGPFLFIQDNIS----------FYATIGLCPPFIVVLTVLICHKYKKQFRYESQLQMIQVTG--- 583

  Fly   904 GAVGHINPDLTLDEQAELL-----PYNREFEFPRENLKLGKQLGAGAFGVVLKGEAKGIRREEPT 963
                      .||.:...:     .|:.::|||||||:.||.||:||||.|:...|.||.:...:
  Rat   584 ----------PLDNEYFYIDFRDYEYDLKWEFPRENLEFGKVLGSGAFGRVMNATAYGISKTGVS 638

  Fly   964 TTVAVKMVKATADNEVVRALVSELKIMVHLGQHLNVVNLLGAVTKNIAKRELMVIVEYCRFGNIQ 1028
            ..|||||:|..||.....||::|||:|.|||.|.|:||||||.|   ....:.:|.|||..|::.
  Rat   639 IQVAVKMLKEKADRCEREALMAELKMMTHLGHHDNIVNLLGACT---LSGPVYLIFEYCCHGDLL 700

  Fly  1029 NFLLRNRKCFINQINPDTDHIDPSIMTQRMSDNYELHRDTNGGGLKYANVGFPIHSYINEP---- 1089
            |:|...|:.|                          ||       .:..: |..|::...|
  Rat   701 NYLRSKREKF--------------------------HR-------TWTEI-FKEHNFSFYPTFQS 731

  Fly  1090 HNNNTQPPTHRRNSDNDPRSGTRAGRTGSGTATYSYDRQMDTCATVMTTVPEDDQI--MSNNSVQ 1152
            |:|::.|             |:|.                      :...|..||:  .:.||:.
  Rat   732 HSNSSMP-------------GSRE----------------------VQIYPPVDQVSGFNGNSIH 761

  Fly  1153 PAWRSNYKT------DSTEAMTVTTV-DLISWAFQVARGMDYLSSKKVLHGDLAARNILLCEDNV 1210
            ......|:.      :..|.:.|.|. ||:.:|:|||:||::|..|..:|.||||||:|:....|
  Rat   762 SEGNIEYENQKRLEEEEEEDLNVLTFEDLLCFAYQVAKGMEFLEFKSCVHRDLAARNVLVTHGKV 826

  Fly  1211 VKICDFGLARSMYRGDNYKKSENGKLPIKWLALESLSDHVFSTYSDVWSYGIVLWEMFSLAKVPY 1275
            ||||||||||.:....:|....|.:||:||:|.|||.:.:::..||||||||:|||:|||...||
  Rat   827 VKICDFGLARDILSDSSYVVRGNARLPVKWMAPESLFEGIYTIKSDVWSYGILLWEIFSLGVNPY 891

  Fly  1276 PGIDPNQELFNKLNDGYRMEKPKFANQELYEIMLECWRKNPESRPLFAELEKRFANMLGEDVASH 1340
            |||..:...:..:..|::||:|.:|.:|:|.:|..||..:...||.|..|.......|.|..|:.
  Rat   892 PGIPVDANFYKLIQSGFKMEQPFYATEEIYFVMQSCWAFDSRKRPSFPNLTSFLGCQLAEAEAAM 956

  Fly  1341 Y------LDLNNPYMQSN 1352
            |      :.|.:|.:..|
  Rat   957 YQNMGGDVPLEHPAIYQN 974

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pvr	NP_001162911.1	IG	346..432	CDD:214652	17/96 (18%)
		Ig	<363..432	CDD:299845	12/70 (17%)
		Ig	466..533	CDD:299845	15/79 (19%)
		IG_like	672..754	CDD:214653	16/83 (19%)
		Ig	674..739	CDD:143165	13/66 (20%)
		IGc2	779..840	CDD:197706	17/79 (22%)
		PKc_like	927..1332	CDD:304357	145/417 (35%)
		Pkinase_Tyr	935..1329	CDD:285015	139/406 (34%)
Flt3	NP_001094292.1	ig	255..345	CDD:278476	18/116 (16%)
		PKc_like	572..949	CDD:304357	149/461 (32%)
		Pkinase_Tyr	610..945	CDD:285015	139/406 (34%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	287	1.000	Domainoid score	I1517
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D126783at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.920