DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Pvr and Flt4

DIOPT Version :9

Sequence 1:	NP_001162911.1	Gene:	Pvr / 34127	FlyBaseID:	FBgn0032006	Length:	1577	Species:	Drosophila melanogaster
Sequence 2:	NP_446104.2	Gene:	Flt4 / 114110	RGDID:	621737	Length:	1363	Species:	Rattus norvegicus

Alignment Length:	1588	Identity:	389/1588 - (24%)
Similarity:	623/1588 - (39%)	Gaps:	417/1588 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    41 GGENG----APLMTPCKSAIILDAQTSTTLKCEDDEPMSWWTSQSQYVHVKSFDNTED------- 94
            |..||    .|.:...:.:.::|...|.::.|....|:.|....:|.|......::||
  Rat    20 GLANGYSMTPPTLNITEDSYVIDTGDSLSISCRGQHPLEWTWPGAQEVLTTGGKDSEDTQVVQDC 84

  Fly    95 ---PARPFGTSLHLIEVTADYVAAYYCVKTSKFSQIAKEEQSDEAMIELVNQGYASSIYVYVNDP 156
               .|||:...|.|.:..|:...:|||.    :..|       :|.||...   |:|.||:|.|.
  Rat    85 EGTEARPYCKVLSLAQTHANNTGSYYCY----YKYI-------KARIEGTT---AASTYVFVRDF 135

  Fly   157 DTKLVDSHNVVTARQYTDVVIPCKPAMPDTEVLLETSNGEMHSSKSVGRYDPQRGFTIEIRSIVD 221
            :...::..:.:...:...:.:||..::|...:.|.:.:..:|.......:|.:||..:....:.|
  Rat   136 EQPFINKPDTLLVNRKDSMWVPCLVSIPGLNITLRSQSSVLHPDGQEVLWDDRRGMRVPTLLLRD 200

  Fly   222 GGDYYCRPNPPFPHNEEEMTSIEVRFIATGLDIPRTQTTNMVYTYAPGVTDGDDEVLTVTNQSTG 286
            .....|.                                         .|.||.:.|     |..
  Rat   201 ALYLQCE-----------------------------------------TTWGDQDFL-----SNP 219

  Fly   287 NLALIRGGDGTLSRERARRSPARLAPMNASPSPRPGQDGKPLPKPVIRSSVEHHVFTDTNFTLDC 351
            .|..|.|.:              |..:...|                :.|:|  :.......|:|
  Rat   220 FLVHITGNE--------------LYDIQLYP----------------KKSLE--LLVGEKLVLNC 252

  Fly   352 EQSAYVESVYGMEWFTPSRDENRIFASQSRTDPKTRN-STHQTGRSTLTVLNAQPSDTGLYKCVT 415
            ...|..:|....:|..|.:.     |.:::..|:.|: .||....|.||:.|....|.|.|.|
  Rat   253 TVWAEFDSGVTFDWDYPGKQ-----AERAKWVPERRSQQTHTELSSILTIHNVSQHDLGPYVC-- 310

  Fly   416 TDNSNQNVQRATYRIKVLKQNESYLNVGEPSGHYNVQEYANRTIQMTANFEGFPTPSFSWFKPDG 480
              .:|..:||.....:|:...:.:::|....|........:..:::......:|.|.|.|:| |.
  Rat   311 --EANNGIQRFRESTEVIVHEKPFISVEWLKGPVLEATAGDEMVKLPVKLAAYPPPEFQWYK-DR 372

  Fly   481 TEVRQSENNFKILSTELSTMLQVLNAQLQDSGTYVLRGSNSFGVVQREYNVS---VMDAP----- 537
            ..|....|...::..|::.         ..:|.|.|...||...:::  |:|   |::.|
  Rat   373 KAVTGRHNPHALVLKEVTE---------ASAGVYTLALWNSAAGLRQ--NISLELVVNVPPHIHE 426

  Fly   538 ALKMSDAYVQVGSVARLECTVRSYP-PAIVTFFFRPCSLEPQWPTCSVLNQNFSLPSEQEKYQFQ 601
            ....|.:.....|...|.||....| |..|.:.:||      |..|....|. ||...|
  Rat   427 KEASSPSIYSRHSRQTLTCTTYGVPQPLSVQWHWRP------WTPCKTFAQR-SLRRRQ------ 478

  Fly   602 TRPRPGKLSVERIYEVSFLPTEPGI-----LTCIAQNIIDGKERRTLTKAHVLLGNIS------- 654
              ||.|........||:   |:..:     |....:: ::|| .:|::|..:...|:|
  Rat   479 --PRDGMPQCRDWKEVT---TQDAVNPIESLDTWTES-VEGK-NKTVSKLVIQDANVSAMYKCVV 536

  Fly   655 ------ENMTIY--------GFDKDHKIAKE----DNVNFTCEALAYHFDGNLKWF-INGEDLKE 700
                  :...||        ||..:.:.:::    .:|..:|.|..|.:: :|:|: :|...|.:
  Rat   537 FNKVGQDERLIYFYVTTIPDGFSIESEPSEDPLEGQSVRLSCRADNYTYE-HLRWYRLNLSTLHD 600

  Fly   701 SD---------SVHIETSHTKYSYKS----------TVHITTISDRDRGTYECRAYHNDKDAVYS 746
            :.         :||:..:..:.:.:.          :::|..::..|.|.|.|.        |..
  Rat   601 AQGNPLLLDCKNVHLFATPLEANLEEAEPGARHATLSLNIPRVAPEDEGDYVCE--------VQD 657

  Fly   747 SREIDLYVHDP-------SAPQWTNGGQEGHSKIKRKLSQTLELECASTAVPVAIVRWFKDDKEV 804
            .|..|.:.|..       .||:.|    :..:.:...:|.:||:.|......|..:.|:||::
  Rat   658 RRNQDKHCHKKYLSVQALEAPRLT----QNLTDLLVNVSDSLEMRCPVAGAHVPSIVWYKDER-- 716

  Fly   805 TESKLRHIIEKES---------KLLITHLYPGDEGVYKCVVENRLDRIERSFTVVISD------- 853
                   ::||||         :|.|..:...|.|.|.|.|.|....:..|.:|.:..
  Rat   717 -------LLEKESGIDLADSNQRLSIQRVREEDAGRYLCSVCNAKGCVNSSASVAVEGSEDKGSM 774

  Fly   854 ----LPGISMAWVWFGVILFLILIGLCVFLAVRYQKEHKRHLALKAAGLANFEEGAVGHINP-DL 913
                |.|..:..|:|.|:|.||...:          :...|..:|...|:..       ::| ::
  Rat   775 EIVILIGTGVIAVFFWVLLLLIFCNM----------KRPAHADIKTGYLSII-------MDPGEV 822

  Fly   914 TLDEQAELLPYN-REFEFPRENLKLGKQLGAGAFGVVLKGEAKGIRREEPTTTVAVKMVKATADN 977
            .|:||.|.|.|: .::|||||.|.||:.||.||||.|::..|.||.:.....||||||:|..|..
  Rat   823 PLEEQCEYLSYDVSQWEFPRERLHLGRVLGHGAFGKVVEASAFGINKGSSCDTVAVKMLKEGATA 887

  Fly   978 EVVRALVSELKIMVHLGQHLNVVNLLGAVTKNIAKRELMVIVEYCRFGNIQNFLLRNRKCFINQI 1042
            ...|||:|||||::|:|.||||||||||.||  ....||||||:|::||:.|||...|:.|
  Rat   888 SEHRALMSELKILIHIGNHLNVVNLLGACTK--PNGPLMVIVEFCKYGNLSNFLRVKRETF---- 946

  Fly  1043 NPDTDHIDPSIMTQRMSDNYELHRDTNGGGLKYANVGFPIHSYINEPHNNNTQPPTHRRNSDNDP 1107
                   ||                       ||.                 :.|..||..
  Rat   947 -------DP-----------------------YAE-----------------KSPEQRRRF---- 960

  Fly  1108 RS---GTRAGRTGSGTATYSYDRQMDTCATVMTTVPEDDQIMSNNSVQPA---------WRSNYK 1160
            |:   |.:|.|...|    |.||.:.|           ..:|...|.:.|         |.|
  Rat   961 RAMVEGAKADRRRLG----STDRALFT-----------RFLMGKGSARRAPFVQEAEDLWLS--- 1007

  Fly  1161 TDSTEAMTVTTVDLISWAFQVARGMDYLSSKKVLHGDLAARNILLCEDNVVKICDFGLARSMYRG 1225
                   .:|..||:.::||||.||::|:|:|.:|.|||||||||.|.::||||||||||.:|:.
  Rat  1008 -------PLTMEDLVCYSFQVALGMEFLASRKCIHRDLAARNILLSESDIVKICDFGLARDIYKD 1065

  Fly  1226 DNYKKSENGKLPIKWLALESLSDHVFSTYSDVWSYGIVLWEMFSLAKVPYPGIDPNQELFNKLND 1290
            .:|.:..:.:||:||:|.||:.|.|::|.|||||:|::|||:|||...||||:..|:|...:|.|
  Rat  1066 PDYVRKGSARLPLKWMAPESIFDKVYTTQSDVWSFGVLLWEIFSLGASPYPGVQINEEFCQRLKD 1130

  Fly  1291 GYRMEKPKFANQELYEIMLECWRKNPESRPLFAELEKRFANML----GEDVASHYLDLNNPYMQS 1351
            |.||..|:.|...:..||..||..:|::||.|::|.:...::|    .::.....:.|::.....
  Rat  1131 GTRMRAPELATPAIRHIMQSCWSGDPKARPAFSDLVEILGDLLQGGGWQEEEEECMALHSSQSSE 1195

  Fly  1352 NIEYMKKQSTDYLALMGSPDELAP-------AAPRYVN-----GHIVPDIR---------IEELP 1395
            ...:| :.||..|.:..:..|.:|       .|.||.|     |.:|...:         .||||
  Rat  1196 EDGFM-QASTTALHITEADAESSPPSMHCHSLAARYYNCVSFPGRLVRGTKAPGSSRMKTFEELP 1259

  Fly  1396 --DDYMEMSRDSDPDACTAIFSPT--------RLEGE------------SSDFPDFSSETTFNFP 1438
              ....:.|.|:..|:...:.|..        |.||.            |...||..........
  Rat  1260 MTPTTYKASVDNQTDSGMVLASEEFEQIESRHRQEGSFSRKDPGQHMDISRGHPDLQGRRRRPTQ 1324

  Fly  1439 GARQSPTLSNNLNSGSSKPLRKKNGMPT 1466
            ||:......||.....|:|..:.:..|:
  Rat  1325 GAQGGKVFYNNEYGEVSQPCTEGDCCPS 1352

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pvr	NP_001162911.1	IG	346..432	CDD:214652	22/86 (26%)
		Ig	<363..432	CDD:299845	18/69 (26%)
		Ig	466..533	CDD:299845	16/69 (23%)
		IG_like	672..754	CDD:214653	18/101 (18%)
		Ig	674..739	CDD:143165	15/84 (18%)
		IGc2	779..840	CDD:197706	19/69 (28%)
		PKc_like	927..1332	CDD:304357	162/416 (39%)
		Pkinase_Tyr	935..1329	CDD:285015	157/405 (39%)
Flt4	NP_446104.2	Ig_2	137..220	CDD:404734	15/128 (12%)
		IgI_VEGFR	230..329	CDD:409448	26/125 (21%)
		Ig strand B	248..252	CDD:409448	1/3 (33%)
		Ig strand C	263..267	CDD:409448	0/3 (0%)
		Ig strand E	293..297	CDD:409448	2/3 (67%)
		Ig strand F	307..312	CDD:409448	2/8 (25%)
		Ig strand G	320..323	CDD:409448	0/2 (0%)
		Ig	331..418	CDD:416386	18/98 (18%)
		Ig strand A	332..337	CDD:409353	1/4 (25%)
		Ig strand A'	342..347	CDD:409353	0/4 (0%)
		Ig strand B	349..360	CDD:409353	0/10 (0%)
		Ig strand C	364..370	CDD:409353	3/5 (60%)
		Ig strand C'	372..375	CDD:409353	0/2 (0%)
		Ig strand D	378..380	CDD:409353	0/1 (0%)
		Ig strand E	382..387	CDD:409353	0/4 (0%)
		Ig strand F	395..403	CDD:409353	3/7 (43%)
		Ig strand G	409..418	CDD:409353	2/10 (20%)
		IG_like	570..663	CDD:214653	17/101 (17%)
		Ig strand B	574..578	CDD:409353	1/3 (33%)
		Ig strand C	587..591	CDD:409353	1/3 (33%)
		Ig strand E	636..640	CDD:409353	0/3 (0%)
		Ig strand F	650..655	CDD:409353	2/12 (17%)
		IGc2	693..755	CDD:197706	19/70 (27%)
		Ig strand B	695..699	CDD:409353	2/3 (67%)
		Ig strand C	708..712	CDD:409353	0/3 (0%)
		Ig strand E	731..735	CDD:409353	1/3 (33%)
		Ig strand F	745..750	CDD:409353	2/4 (50%)
		VEGFR-2_TMD	770..804	CDD:375470	8/43 (19%)
		PKc_like	837..1175	CDD:419665	163/419 (39%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1289..1330		8/40 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	287	1.000	Domainoid score	I1517
eggNOG	1	0.900	-	-		E1_KOG0200
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	414	1.000	Inparanoid score	I1779
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D126783at33208
OrthoFinder	1	1.000	-	-		FOG0001573
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X787
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	9	8.830