DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Pvr and flt3

DIOPT Version :9

Sequence 1:	NP_001162911.1	Gene:	Pvr / 34127	FlyBaseID:	FBgn0032006	Length:	1577	Species:	Drosophila melanogaster
Sequence 2:	XP_012813386.2	Gene:	flt3 / 101733150	XenbaseID:	XB-GENE-481373	Length:	977	Species:	Xenopus tropicalis

Alignment Length:	1113	Identity:	291/1113 - (26%)
Similarity:	440/1113 - (39%)	Gaps:	333/1113 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly   396 STLTVLNAQP----------SDTGLYKCVTTDNSNQNVQRATYRIKVLKQNESYLNVGEPSGHYN 450
            |||    |||          :|.|.|.      :::||.||...::|                 |
Frog    24 STL----AQPAAMISNMRKATDLGCYW------NSENVTRAKLPVEV-----------------N 61

  Fly   451 VQEYANRTIQMTANFEGFPTPSFSWFKPDGT---EVRQSENNFKILSTELSTMLQVLNAQLQDSG 512
            |  :.:.|:::|.|..|.  .|.:|...|.:   .|.|:.|:..::|.||..|.:      :|||
Frog    62 V--FDSVTLEVTQNVSGI--VSCAWVLRDNSAPCRVLQNGNSSLVVSLELVRMSE------KDSG 116

  Fly   513 TYVLRGSNSFGVVQREYNVSVMDAPALKMSDAYVQVGSVARLECTVRSYPPAIVTFFFRPCSLEP 577
            .|.|..:|:        |||..                 ..:|..|:..|.       :|...|.
Frog   117 EYKLLINNN--------NVSYS-----------------VHIELKVKGKPR-------KPFFTES 149

  Fly   578 QWPTCSVLN------QNFSLPS--------EQEKYQFQTRPRPGKLSVERIYEVSFLPTEPGILT 628
            |...|.:.:      ..:.:||        :...:|:......|...|....:..||..|  .:.
Frog   150 QGTVCCISDGYPEPTVYWLMPSSPHGRYEIKNGTHQYNGTNTDGSHRVMNELDSRFLLEE--YIW 212

  Fly   629 CIAQN----------IIDGKERRTLTKAHVLLGNISENMTIYGFDKDHKIAKEDNVNFTCEALAY 683
            |.|.|          .:|....|.|.|..|.:|   |...|                 .|.|:..
Frog   213 CCATNAFGTECTQMYTLDLNSERDLPKISVTVG---EPFII-----------------RCRAIHE 257

  Fly   684 HFDGNLKWFINGEDLKESDSVHI--ETSHTKYSYKS-TVHI-----TTISDRDRGTYECRAYHND 740
            .|...:||..|     .:|.:|.  :||:.:...:| .|.:     :.|...:.|.|.|.:.|..
Frog   258 SFKFGVKWSSN-----STDKLHTFEKTSYVRSPQESRMVRVLFATSSQIKKANSGIYTCSSTHQQ 317

  Fly   741 KDAVY---------------------SSREIDLYVHDPSAP----QW--------TNGGQEGHSK 772
            ..:|.                     .|:|...:|...:.|    .|        .....||.|.
Frog   318 SKSVQVILLDKGFIRLNTSREEYTIDQSKEFCFHVTFEAYPAARCTWLYQSSHFPCENTTEGAST 382

  Fly   773 IK------------------------------------RKLSQTLE--LECASTAVPVAIVRW-- 797
            .|                                    .|...:::  :.|.|:|.|:|:..|
Frog   383 SKYCNHKYMPGEYTFYIENEDVQLHKTFILHLLKKPEVHKTDGSMQDYMSCTSSANPLAVWSWKR 447

  Fly   798 FKDD-----KEVTESKLRHIIEKESKLLITH--LYPGD-EGVY---KCVVENRLDRIERS----- 846
            .::|     :::|...|..|.|:.|...|:.  ||.|: .|.:   .|.:.:.....||.
Frog   448 SREDLSNCTEDITGGILYGIAERMSDTWISRSSLYIGNITGTFWICCCAINSAGLTCERMPLIKA 512

  Fly   847 -------FTVVISDLPGISMAWVWFGVILFLILIGLCVFLAVRYQKEHKRHLALKAAGLANFEEG 904
                   |..|::.|..||        |||||        |:.|.|..|::|......:
Frog   513 IVKQNSYFIPVVTCLCAIS--------ILFLI--------ALIYSKSQKKNLYQSQLQM------ 555

  Fly   905 AVGHINPD----LTLDEQAELLPYNREFEFPRENLKLGKQLGAGAFGVVLKGEAKGIRREEPTTT 965
             :.:|.|.    :.:|  ..:|.|:.::|||||||:.||.||:||||.|:...|.||.:...:..
Frog   556 -IQYIGPSDNEYIYID--FSILEYDLKWEFPRENLEFGKVLGSGAFGRVVTATAYGITKPGVSLQ 617

  Fly   966 VAVKMVKATADNEVVRALVSELKIMVHLGQHLNVVNLLGAVTKNIAKRELMVIVEYCRFGNIQNF 1030
            |||||:|..||.....||:||||:|..:|.|.|:||:|||.|   |...:.:|.||||.|::.|:
Frog   618 VAVKMLKENADGSEKDALMSELKMMTQIGHHQNIVNMLGACT---AAGPVYLIFEYCRHGDLLNY 679

  Fly  1031 LLRNRKCFINQINPDTDHIDPSIMTQRMSDNYELHRDTNGGGLKYANVGFPIHSYINEPHNNNTQ 1095
            |...|:.|         |   ...|..:.|:               |..| .|::...      |
Frog   680 LRNERETF---------H---KTWTDVVKDH---------------NFSF-YHNFTQH------Q 710

  Fly  1096 PPTHRRNSDNDPRSGTRAGRT-GSGTATYSYDRQMDTCATVMTTVPEDDQIMSNNSVQPAWRSNY 1159
            .|:.||.|..|..|.....|| .||.:...:|..:: |       .::|    |......:.:..
Frog   711 KPSVRRESLLDNGSYMAENRTLVSGNSQQRWDFSLN-C-------EQND----NQEELIKYENTR 763

  Fly  1160 KTDSTEAMTVTTVDLISWAFQVARGMDYLSSKKVLHGDLAARNILLCEDNVVKICDFGLARSMYR 1224
            ..|..:...:|..||:.:::|||:||::|.||..:|.||||||||:....|.|||||||||.:..
Frog   764 CYDEEDLHVLTFEDLLCFSYQVAKGMEFLESKLCIHRDLAARNILITNGKVAKICDFGLARDIEN 828

  Fly  1225 GDNYKKSENGKLPIKWLALESLSDHVFSTYSDVWSYGIVLWEMFSLAKVPYPGIDPNQELFNKLN 1289
            ..||....|.:||:||:|.||:.:.:::..||||||||:|||:|||...|||||..|.:.:..|.
Frog   829 DLNYVVKGNARLPVKWMAPESIFEGIYTIKSDVWSYGILLWEIFSLGINPYPGIQVNAQFYKLLQ 893

  Fly  1290 DGYRMEKPKFANQELYEIMLECWRKNPESRPLFAELEKRFANMLGEDVASHYLDLNNPYMQSNIE 1354
            .|::||:|.::..|:|.:|..||..:...||.|.:|    .:.||             |..||.|
Frog   894 SGFKMEQPFYSTNEIYFLMQSCWAFDSRKRPSFPQL----VSFLG-------------YQISNTE 941

  Fly  1355 YMKKQSTD 1362
            .:..|:.|
Frog   942 ALVYQNMD 949

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pvr	NP_001162911.1	IG	346..432	CDD:214652	13/45 (29%)
		Ig	<363..432	CDD:299845	13/45 (29%)
		Ig	466..533	CDD:299845	19/69 (28%)
		IG_like	672..754	CDD:214653	20/110 (18%)
		Ig	674..739	CDD:143165	16/72 (22%)
		IGc2	779..840	CDD:197706	18/75 (24%)
		PKc_like	927..1332	CDD:304357	150/405 (37%)
		Pkinase_Tyr	935..1329	CDD:285015	144/394 (37%)
flt3	XP_012813386.2	Ig	240..315	CDD:416386	20/99 (20%)
flt3	XP_012813386.2	PKc_like	549..937	CDD:419665	158/462 (34%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	299	1.000	Domainoid score	I1422
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D126783at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	3.010