DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Pvr and tie1

DIOPT Version :9

Sequence 1:	NP_001162911.1	Gene:	Pvr / 34127	FlyBaseID:	FBgn0032006	Length:	1577	Species:	Drosophila melanogaster
Sequence 2:	XP_002931650.3	Gene:	tie1 / 100496664	XenbaseID:	XB-GENE-922217	Length:	1127	Species:	Xenopus tropicalis

Alignment Length:	974	Identity:	226/974 - (23%)
Similarity:	367/974 - (37%)	Gaps:	294/974 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly   451 VQEYANRTIQMTANFEGFPTP---SFSWFKPDGTEVRQSENNFKILSTELSTM-LQVLNAQLQDS 511
            |:...|.:..:|....|.|.|   |....:|||:.:..|:   .:|..|.||. ..|.:..|.|:
Frog   351 VEVNLNSSAVLTCAASGNPQPIRESIELRRPDGSVLAASK---AVLDRERSTCEFAVQSLTLTDN 412

  Fly   512 GTYVLRGSNSFGVVQREYNVSV------MDAPALKMSDAYVQVGSVARLECTVRSYPPAIVTFFF 570
            |.:..|.|.:.|...|::.|.|      ::.|.|  .|...|..:::.|.......|...:...:
Frog   413 GLWECRVSTTGGQDSRKFQVHVKVPPLPIEPPLL--LDRRSQQLTLSPLHNFSGDGPIISIKLHY 475

  Fly   571 RPCSLEPQWPTCSVLNQNFSLPSEQEK----YQFQ---TRPRP---GKLSVERIYEVSFLPTEPG 625
            :|...:..|... |:.|..::..::.|    |..:   :||.|   |.|....:.|...  .||.
Frog   476 KPKDNDSPWKNI-VVKQKENIILQKLKPVTSYLIRAQLSRPGPGGEGPLGPLAVMETDC--QEPT 537

  Fly   626 ILTCIAQNIIDGKERRTL-----TKAHVLLGNISENMTIYGF------DKDHKIAKED------- 672
            :...|..:.::  :|.||     ..:..::||        ||      .::|.|.:|:
Frog   538 VKPVIKGHAVE--DRNTLYISWNLPSTPVIGN--------GFLLQIYHPENHLIRQENITSMYVL 592

  Fly   673 ---------NVNFTCEALAYHFDGNLKWFINGEDLKESDSVHIETSHTKYSYKSTVHITTISDRD 728
                     |..:|.:.|.||.          .:|.......:.|.|:|              ..
Frog   593 SRKVYGLHANKEYTLKVLIYHC----------RNLGPPSDPFVVTIHSK--------------GP 633

  Fly   729 RGTYECRAYHNDKDAV------------------YSSREIDLYVHDPSAPQWT---NGGQEGHSK 772
            ....:.||....:|::                  ..||.:.:    |..|||.   |..|..|..
Frog   634 SPPKDLRAEPISRDSIKLSWLPPDDPNGGIIKYTVESRPVGI----PGEPQWADTENQNQTWHII 694

  Fly   773 IKRKLSQTLELEC-ASTAVPVAIVRWFKDDKEVTESKLRHIIE-------KESKLLITHLYPGDE 829
            .....|...:... |::.||   ..|     .::.....|.:|       .|||      .|...
Frog   695 SGLNASTFYQFRVRANSKVP---GEW-----SLSVQSTAHSLEIGSQPPSMESK------NPRPS 745

  Fly   830 GVYKCVVENRLDRIERSFTVVISDLPGISMAWVWFGVILFLILIGLCVFLAVRYQKEHKRHLALK 894
            |              .|..::::.:..:|       :..|.|::.|.....::....|:|.:...
Frog   746 G--------------SSHQLILAIIGSVS-------ITCFTIILALLALFCIKKNFFHRRRMFTY 789

  Fly   895 AAGLANFEEGAVGHINPDLTLDEQAELLPYNREFEFP---RENLKLGKQLGAGAFGVVLKGEAKG 956
            .:|  :.||..:...:..|||..:..  |....|.:|   .|::|....:|.|.||.|:|..
Frog   790 QSG--SGEETILQFSSGTLTLSRRPR--PQTEPFSYPVLEWEDIKFEDVIGEGNFGQVIKAM--- 847

  Fly   957 IRREEPTTTVAVKMVKATADNEVVRALVSELKIMVHLGQHLNVVNLLGAVTKNIAKRELMVIVEY 1021
            |:::......|:||:|..|.....|....||:::..||.|.|::|||||...   :..|.:.:||
Frog   848 IKKDGQKMNAAIKMLKEFASENDHRDFAGELEVLCKLGHHPNIINLLGACEN---RGYLYIAIEY 909

  Fly  1022 CRFGNIQNFLLRNRKCFINQINPDTDHIDPSIMTQRMSDNYELHRDTNGGGLKYANVGFPIHSYI 1086
            ..:||:.:||.::|
Frog   910 APYGNLLDFLRKSR--------------------------------------------------- 923

  Fly  1087 NEPHNNNTQPPTHRRNSDNDPRSGTRAGRTGSGTATYSYDRQMDTCATVMTTVPEDDQIMSNNSV 1151
                                                                |.|.|
Frog   924 ----------------------------------------------------VLETD-------- 928

  Fly  1152 QPAWRSNYKTDSTEAMTVTTVDLISWAFQVARGMDYLSSKKVLHGDLAARNILLCEDNVVKICDF 1216
             |.:...:.|    |.|:|:..|:.:|..||:||.|||.|:.:|.||||||:|:.|:.|.||.||
Frog   929 -PVFAKEHGT----ASTLTSQQLLQFASDVAKGMQYLSEKQFIHRDLAARNVLVGENLVTKIADF 988

  Fly  1217 GLARSMYRGDN-YKKSENGKLPIKWLALESLSDHVFSTYSDVWSYGIVLWEMFSLAKVPYPGIDP 1280
            ||:    ||:. |.|...|:||::|:|:|||:..|::|.|||||:|::|||:.||...||.|: .
Frog   989 GLS----RGEEVYVKKTMGRLPVRWMAIESLNYSVYTTKSDVWSFGVLLWEIVSLGGTPYCGM-T 1048

  Fly  1281 NQELFNKLNDGYRMEKPKFANQELYEIMLECWRKNPESRPLFAELEKRFANMLGEDVASHYLDL 1344
            ..||:..|..|||||||:..:.|:||:|.:|||..|..||.|:::..:...||  |....|:::
Frog  1049 CAELYENLPQGYRMEKPRNCDDEVYELMRQCWRDRPYERPPFSQISIQLTRML--DARKAYVNM 1110

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pvr	NP_001162911.1	IG	346..432	CDD:214652
		Ig	<363..432	CDD:299845
		Ig	466..533	CDD:299845	21/70 (30%)
		IG_like	672..754	CDD:214653	14/115 (12%)
		Ig	674..739	CDD:143165	10/64 (16%)
		IGc2	779..840	CDD:197706	11/68 (16%)
		PKc_like	927..1332	CDD:304357	119/408 (29%)
		Pkinase_Tyr	935..1329	CDD:285015	116/394 (29%)
tie1	XP_002931650.3	IG_like	124..203	CDD:214653
		EGF_CA	<222..247	CDD:238011
		EGF_CA	306..336	CDD:238011
		Ig	341..432	CDD:416386	23/83 (28%)
		Ig strand A	341..345	CDD:409353
		Ig strand A'	351..355	CDD:409353	1/3 (33%)
		Ig strand B	358..367	CDD:409353	1/8 (13%)
		Ig strand C	375..380	CDD:409353	1/4 (25%)
		Ig strand C'	384..386	CDD:409353	0/1 (0%)
		Ig strand D	390..394	CDD:409353	0/6 (0%)
		Ig strand E	397..405	CDD:409353	2/7 (29%)
		Ig strand F	413..421	CDD:409353	2/7 (29%)
		Ig strand G	424..432	CDD:409353	2/7 (29%)
		fn3	448..511	CDD:394996	10/63 (16%)
		FN3	633..724	CDD:238020	17/102 (17%)
		PTKc_Tie1	826..1122	CDD:270671	121/414 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910