DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Pvr and kdrl

DIOPT Version :9

Sequence 1:	NP_001162911.1	Gene:	Pvr / 34127	FlyBaseID:	FBgn0032006	Length:	1577	Species:	Drosophila melanogaster
Sequence 2:	XP_017952305.2	Gene:	kdrl / 100495109	XenbaseID:	XB-GENE-6071790	Length:	1329	Species:	Xenopus tropicalis

Alignment Length:	1391	Identity:	360/1391 - (25%)
Similarity:	581/1391 - (41%)	Gaps:	350/1391 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    47 PLMTPCKSAIILDAQTSTTLKCEDDEPMSWWTSQSQYVHVKSFDNTEDPARPFGTSLHLIEVTAD 111
            |:::|.|..:.::...|.|..|.....:.|..::..::..:.|........|........::|
Frog    35 PVISPRKDHVHINKGESFTFTCRGSGKLKWDLAEMSHLSNRRFSILPQCRGPDENQRVCSQLT-- 97

  Fly   112 YVAAYYCVKTSKFSQIAKEEQSDEAMIELVNQGYA-----SSIYVYVNDPDTKLVDSH----NVV 167
                           |:....:|..:|....:|.:     ::||:||.|.....|:..    .::
Frog    98 ---------------ISNAHPNDTGLISCHYRGSSNLKRIATIYLYVKDDAQPFVEERTEDPELI 147

  Fly   168 TARQYTDVVIPCKPAMPDTEVLLETSNGEMHSSKSVG----RYDPQRGF-----------TIEIR 217
            |......|:|||:...||..|.|.    .:.|.|.|.    .::|::||           .:|..
Frog   148 TYTNEEMVIIPCRVTSPDYRVSLR----GLFSKKQVNTPEMTWNPKKGFIFSSPPNSVQEVLECV 208

  Fly   218 SIVDGGDYYCRPNPPFPHNEEEMTSIEVRFIATGLDIPRTQTTNMVYTYAPGVTDGDDEVLTVTN 282
            ::|:|..:                        :.|.|.:.:..|:..|             |||.
Frog   209 AVVNGKKF------------------------SSLYILQKENYNVTIT-------------TVTA 236

  Fly   283 QSTGNLALIRGGDGTLSRERARRSPARLAPMNASPSPRPGQDGKPLPKPVIRSSVEHHVFTDTNF 347
            .:|                       ||..            |.||
Frog   237 SAT-----------------------RLVV------------GDPL------------------- 247

  Fly   348 TLDCEQSAYVESVYGMEWFTPSRDENRIFASQSRTDPKTRNSTHQTGRSTLTVLNAQPSDTGLYK 412
            ||.|:......|...::|.    ..|::..|.|..   :...|...|..|:.:.:....:.|:|.
Frog   248 TLFCKGETGYNSRVLLDWV----HGNKVLKSISTF---SNEQTPYVGTRTVNISHISLHEQGVYT 305

  Fly   413 C---VTTDNSNQNVQRATYRIKVLKQNESYLNVGEPSGHYNVQEYANRTIQMTANFEGFPTPSFS 474
            |   :.|    ||.::...|:    ..:.:||:..|.|..:......:.:::||..:..|.|..:
Frog   306 CRDRIYT----QNFKKIYIRV----YEKGFLNISTPDGQIHEVNEGTKQVKLTAKVDALPKPVVT 362

  Fly   475 WFKPDGTEVRQSENNFKILSTELSTMLQVLNAQLQDSGTYVLRGSNSFGVVQREYNVS------V 533
            |:: :|..:..:...:|....:.|  |.:.|...:|||:|.:..|||:      ||.|      |
Frog   363 WYR-NGVPIGANHTCYKPEPEDYS--LVIKNPSEKDSGSYTMVLSNSW------YNKSISFILIV 418

  Fly   534 MDAPAL--KMSDAYVQ----VGSVARLECTVRSYPPAIVTFFFRPCSLE-------------PQW 579
            ...|.:  |.:|..:.    :|......|||..:|...:.:.|:||...             |..
Frog   419 NVKPKIYEKETDFNIPKPLLLGEPHNFRCTVYGHPLPQIRWEFQPCHSSNTLCEVDDAIPRIPVI 483

  Fly   580 PTCSVLNQNFS--LPSEQEKYQFQTRPRPGKLSVERIYEVSFLPT-----EPGILTCIAQNIIDG 637
            |..|..|::.|  .|..:|....||:   .||       ||.|.|     :.||..|||.|:: .
Frog   484 PERSHTNESISDARPVIEESIMEQTK---NKL-------VSILTTSRYSNQSGIFFCIASNVM-A 537

  Fly   638 KERRTLTKAHVLLGNISENMT------IYGFDKDHKIAKEDNVNFTCEALAYHFDGNLKWFING- 695
            :.:|::   |.:|.:|....|      ::|.|          |...|.|..|.:. ||.|...|
Frog   538 EVKRSM---HFILSDIKPEETKERTEALHGSD----------VKLVCRAERYIYT-NLSWTFPGK 588

  Fly   696 EDLKESDSVH---IETSHTKYSYKSTVHITTISDRDRGTYECRAYHNDKDAVYSSRE-----IDL 752
            |::...:.||   .:.::.:|:....:.:..::....||:.|.|.:     :|:..:     |||
Frog   589 EEIPCLEEVHPQMTKNTYQEYTMSCLLLLKNVTQELAGTFRCSATN-----LYTGMQEEKNVIDL 648

  Fly   753 YVHDPSAPQWTNGGQEGHSKIKRKL-------SQTLELECASTAVPVAIVRWFKDDKEVTESKLR 810
            .:.:..|||           :.::|       |.||.|||.....|...:.|.|:...:..:...
Frog   649 VIKEKEAPQ-----------VIQELVPMVVNSSSTLFLECRVNGTPTPTIIWLKNGYVIKPASGI 702

  Fly   811 HIIEKESKLLITHLYPGDEGVYKCVVENRLDRIERSFTVVI------SDLPGISMAWVWFGVILF 869
            .:: ..|.|:|..:...|||||.|...|.|.::..|..:.:      |::..|.:........||
Frog   703 TLV-YNSTLVIERVKKDDEGVYICEAVNELGKVSTSAFITVQGVEEKSNIEVIILVCTGVAATLF 766

  Fly   870 LILIGLCVFLAVRYQKEHKRHLALKAAGLANFEEGAVGHINPD-LTLDEQAELLPY-NREFEFPR 932
            .:|:.|.:      :|..|.|.:....|..:.      .::|| :.||||.|.||| :.::||||
Frog   767 WLLLTLFI------RKLKKPHGSDMKTGYLSI------IMDPDEIPLDEQCERLPYDSSKWEFPR 819

  Fly   933 ENLKLGKQLGAGAFGVVLKGEAKGIRREEPTTTVAVKMVKATADNEVVRALVSELKIMVHLGQHL 997
            :.|.|||.||.||||.|::..|.||.:.....||||||:|..|.|...:||:|||||::|:|.||
Frog   820 DRLSLGKTLGHGAFGKVVEASAFGIDKSSTCKTVAVKMLKECATNNERKALMSELKILIHIGHHL 884

  Fly   998 NVVNLLGAVTKNIAKRELMVIVEYCRFGNIQNFLLRNRKCFINQINPDTDHIDPSIMTQRMSDNY 1062
            ||||||||.||  ....||||||||::||:.|:|...|..||
Frog   885 NVVNLLGACTK--PGGPLMVIVEYCKYGNLSNYLRSKRGDFI----------------------- 924

  Fly  1063 ELHRDTNGGGLKYANVGFPIHSYINEPHNNNTQPPTHRRNSDNDPRSGTRAGRTGSGTATYSYDR 1127
                     ..||......:|..|::      .....:|..::...:|:.|........:||...
Frog   925 ---------AYKYQEAEKALHGSISD------LSELIKRRLESVASTGSSASSGFIEDKSYSDSE 974

  Fly  1128 QMDTCATVMTTVPEDDQIMSNNSVQPAWRSNYKTDSTEAMTVTTVDLISWAFQVARGMDYLSSKK 1192
            :.|          ||.:.:|.           |..|.|       |||.::||||:||::|:|:|
Frog   975 EED----------EDHEDVSK-----------KLLSME-------DLICYSFQVAKGMEFLASRK 1011

  Fly  1193 VLHGDLAARNILLCEDNVVKICDFGLARSMYRGDNYKKSENGKLPIKWLALESLSDHVFSTYSDV 1257
            .:|.|||||||||.|:||||||||||||.:|:..:|.:..:.:||:||:|.|::.|.:::|.|||
Frog  1012 CIHRDLAARNILLSENNVVKICDFGLARDIYKDPDYVRKGDARLPLKWMAPEAIFDKIYTTQSDV 1076

  Fly  1258 WSYGIVLWEMFSLAKVPYPGIDPNQELFNKLNDGYRMEKPKFANQELYEIMLECWRKNPESRPLF 1322
            ||:|::|||:|||...||||:..:::...:|.:|.||..|.:.:.|:|:.||:||:..|..||.|
Frog  1077 WSFGVLLWEIFSLGASPYPGVQIDEDFCCRLKEGTRMRAPDYCSPEIYQTMLDCWQGEPTDRPTF 1141

  Fly  1323 AELEKRFANMLGEDV---ASHYLDLN 1345
            .:|.:|..::|...|   ...|:.||
Frog  1142 TDLVERLGDLLQASVQQEGKDYIPLN 1167

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pvr	NP_001162911.1	IG	346..432	CDD:214652	18/88 (20%)
		Ig	<363..432	CDD:299845	14/71 (20%)
		Ig	466..533	CDD:299845	18/72 (25%)
		IG_like	672..754	CDD:214653	20/90 (22%)
		Ig	674..739	CDD:143165	16/68 (24%)
		IGc2	779..840	CDD:197706	18/60 (30%)
		PKc_like	927..1332	CDD:304357	157/404 (39%)
		Pkinase_Tyr	935..1329	CDD:285015	152/393 (39%)
kdrl	XP_017952305.2	Ig_3	34..111	CDD:404760	13/92 (14%)
		Ig_3	233..307	CDD:404760	22/134 (16%)
		Ig	327..418	CDD:416386	24/99 (24%)
		Ig strand A	327..330	CDD:409353	1/2 (50%)
		Ig strand A'	337..342	CDD:409353	0/4 (0%)
		Ig strand B	347..355	CDD:409353	2/7 (29%)
		Ig strand C	359..365	CDD:409353	2/5 (40%)
		Ig strand C'	367..370	CDD:409353	1/2 (50%)
		Ig strand D	376..378	CDD:409353	0/1 (0%)
		Ig strand E	384..389	CDD:409353	2/6 (33%)
		Ig strand F	397..405	CDD:409353	2/7 (29%)
		Ig strand G	410..418	CDD:409353	1/7 (14%)
		Ig_3	551..634	CDD:404760	19/93 (20%)
		Ig strand B	567..571	CDD:409353	1/3 (33%)
		Ig strand C	580..584	CDD:409353	2/3 (67%)
		Ig strand E	613..617	CDD:409353	0/3 (0%)
		Ig strand F	627..632	CDD:409353	2/4 (50%)
		I-set	656..742	CDD:400151	24/97 (25%)
		Ig strand A	656..659	CDD:409353	2/13 (15%)
		Ig strand A'	664..667	CDD:409353	0/2 (0%)
		Ig strand B	673..680	CDD:409353	4/6 (67%)
		Ig strand C	686..691	CDD:409353	1/4 (25%)
		Ig strand C'	694..696	CDD:409353	0/1 (0%)
		Ig strand D	702..706	CDD:409353	0/4 (0%)
		Ig strand E	708..712	CDD:409353	2/3 (67%)
		Ig strand F	721..729	CDD:409353	4/7 (57%)
		Ig strand G	732..742	CDD:409353	1/9 (11%)
		PKc_like	814..1155	CDD:419665	158/408 (39%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	299	1.000	Domainoid score	I1422
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H136317
Inparanoid	1	1.050	419	1.000	Inparanoid score	I1763
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D126783at33208
OrthoFinder	1	1.000	-	-		FOG0001573
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X787
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	6.060