DRSC/TRiP Functional Genomics Resources

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Protein Alignment Pvr and kdr

DIOPT Version :10

Sequence 1:NP_001162911.1 Gene:Pvr / 34127 FlyBaseID:FBgn0032006 Length:1577 Species:Drosophila melanogaster
Sequence 2:XP_002934715.3 Gene:kdr / 100487501 XenbaseID:XB-GENE-6053213 Length:1338 Species:Xenopus tropicalis


Alignment Length:1647 Identity:394/1647 - (23%)
Similarity:644/1647 - (39%) Gaps:495/1647 - (30%)


- Green bases have known domain annotations that are detailed below.


  Fly     2 AMLPRLILLPLLLILRISWSDAVPLQQFSPDPDDSIENCGGENGAPLMTPCKSAIILDAQTSTTL 66
            |:||..:||.||..|..|                         ..|.::..|..:::.|..:.|:
 Frog     3 AVLPGCLLLLLLGSLMAS-------------------------DFPSLSAKKDHLVIAANETLTI 42

  Fly    67 KCEDDEPMSW-WTSQSQYVHVKSFDN----TEDPARPFGTSLHLIEVTADYVAAYYCVKTSKFSQ 126
            .|....|::| |...    |..|.:|    :|.....:..:|.|.:|.|:....|.|.       
 Frog    43 ACRGQRPVNWSWPIN----HSNSINNRLSVSECNESSYCLTLTLTKVVANDSGIYKCY------- 96

  Fly   127 IAKEEQSDEAMIELVNQGYASSIYVYVNDPDTKLVDSHN----VVTARQYTDVVIPCKPAMPDTE 187
               .|.|:.          .:|:.|::.|..:..|.|.:    .|...:...|.:||..:.||..
 Frog    97 ---YEDSNA----------TASVRVFIRDERSPFVPSISEQLLAVYITENKTVTVPCLASKPDLN 148

  Fly   188 VLL--ETSNGEMHSSKSVGRYDPQRGFTI--EIRSIVD--------GGDYYCRPNPPFPHNEEEM 240
            |.|  :..:...|.:.:...:|.::||||  |:...|.        .|:.|..|:         .
 Frog   149 VTLCAKYPDSTFHPNGNSIHWDHKKGFTILSELLKTVSWVSCETKLNGEVYRSPS---------Y 204

  Fly   241 TSIEVRFIATGLDI-PRTQTTNMVYTYAPGVTDGDDEVLTVTNQSTGNLALIRGGDGTLSRERAR 304
            ..:.|.|....|.: |..|....|         |:...||.|..:                    
 Frog   205 FVLVVGFKIYSLSMNPHPQVQLAV---------GEKLALTCTAHT-------------------- 240

  Fly   305 RSPARLAPMNASPSPRPGQDGKPLPKPVIRSSVEHHVFTDTNFTLD----CEQSAYVESVY---- 361
                   |:|..                            .:|..|    .|:||..:.:.    
 Frog   241 -------PLNVR----------------------------VDFKWDYPAIMEKSAETKGLKKELH 270

  Fly   362 -GMEWFTPSRDENRIFASQSRT--DPKTRNSTHQTG-----RSTLTVLNAQPSDTGLYKCVTTDN 418
             |:|.       :.||...|.|  |....:.|..||     .||..:::.:|       .:|.|.
 Frog   271 GGLEL-------SGIFIIDSVTLKDRGNYSCTAYTGLMSKTSSTTVIVHEKP-------FITLDE 321

  Fly   419 SNQNVQRATYRIKVLKQNESYLNVGEPSGHYNVQEYANRTIQMTANFEGFPTPSFSWFKPDGTEV 483
            |..:|                           |.....:.:::...:..:|.|...|.|      
 Frog   322 SMDSV---------------------------VVTKVGQKVRIPVKYTAYPMPDIKWLK------ 353

  Fly   484 RQSENNFKILSTELSTMLQ--VLNAQLQ-DSGTYVL---------RGSNSFG-VVQREYNVSVMD 535
                 |.|.|...:..|:.  ::||..: |:|.|.:         :.|::|. |||....:....
 Frog   354 -----NGKPLHHPMVRMVNNLLINAASEKDAGNYTVVLSNVQTKQQESHTFHLVVQVPPKICEKA 413

  Fly   536 APALKMSDAYVQVGSVARLECTVRSYPPAIVTFFFRPCSLEPQWPTCSVLNQNFSLPSEQEKYQF 600
            .||  ..|:| :.|::..|.||....|        .|.|::.:|.    |.:..|..|    ||:
 Frog   414 VPA--PLDSY-KYGNLYILTCTASGIP--------TPVSIKWEWQ----LEEECSFSS----YQY 459

  Fly   601 QTRPRPGKLSVER---------IYEVSFLPTEPGILTCIAQNIIDGKERRTLTK----------- 645
            .....|...:..|         :.|.:...|:          :|:||. :|::|           
 Frog   460 DIGKNPYTCASWRDIFDKNGGNVIETNETRTD----------VIEGKV-KTVSKLVIHSARVSSL 513

  Fly   646 ------------AHVLLGNISENMTIYGFDKDHKIAKEDNVNFTCEALAYHFDGNLKWFINGEDL 698
                        .||:..:::..:.| ....:.|:.:.||:...|.|..:.: ||:.||      
 Frog   514 YRCSATNQAGEDEHVISFHVTRGLEI-DMQPNSKLTERDNITLICTADKFTY-GNVMWF------ 570

  Fly   699 KESDS----------------------VHIETSHTK-YSYKSTVHITTISDRDRGTYECRAYHND 740
            |.|.|                      :|..|::|. .:..|.:.:..||.|::|.|.|.|....
 Frog   571 KLSPSTVEKHHMGWPIPVCKNLVGLVRMHATTTNTNGDNVTSALVLHNISMREQGNYVCVAQDKK 635

  Fly   741 KDAVYS-SREIDL------YVHDPSAPQWTNGGQEGHSKIKRKLSQTLELECASTAVPVAIVRWF 798
            ....|. .|.|.:      :::.....|            .|.:|:|:.::|.::..|...:.||
 Frog   636 TQKKYCLIRHIRIQAQKVPFIYQDLKNQ------------TRNVSETVVVKCQASGTPDPQIIWF 688

  Fly   799 KDDKEVTESKLRHIIEKESKLLITHLYPGDEGVYKCVVENRL--DRIERSFTVVISD-------- 853
            |||..:.|.....:.:....|.|..:...|||:|.|...|.|  .:.|..|||..:|        
 Frog   689 KDDDSLVEDSGIILKDHNRTLTIQRVRKEDEGIYSCRACNDLGCTKSEMYFTVNGTDEKTNLELI 753

  Fly   854 -LPGISMAWVWFGVILFLILIGLCVFLAVRYQKEHKRHLALKAAGLANFEEGAVGHIN-----PD 912
             |.|..:..::|.|:|.:||            :..||         .|..|...|:::     .:
 Frog   754 ILVGTGIIAMFFWVLLVIIL------------RTVKR---------PNGGELKAGYLSIIMDPGE 797

  Fly   913 LTLDEQAELLPYN-REFEFPRENLKLGKQLGAGAFGVVLKGEAKGIRREEPTTTVAVKMVKATAD 976
            :.::||.|.|.|: .::||||:.|||||.||.||||.||:.:|.||.:.....||||||:|..|.
 Frog   798 VPIEEQCERLSYDASKWEFPRDRLKLGKPLGRGAFGQVLEADAFGIDKSGSCKTVAVKMLKEGAT 862

  Fly   977 NEVVRALVSELKIMVHLGQHLNVVNLLGAVTKNIAKRELMVIVEYCRFGNIQNFLLRNRKCFINQ 1041
            .....||:|||||:.|:|.||||||||||.||  ....||||||||:.||:..:|...|..|:  
 Frog   863 TSEHSALMSELKILSHIGHHLNVVNLLGACTK--PGGPLMVIVEYCKNGNLSAYLRSKRSEFV-- 923

  Fly  1042 INPDTDHIDPSIMTQRMSDNYELHRDTNGGGLKYANVGFPIHSYINEPHNNNTQPPTHRR----- 1101
                                  |::                           |:.|.:|:     
 Frog   924 ----------------------LYK---------------------------TKTPRYRKQHYVE 939

  Fly  1102 -NSDNDPRSGTRAGRTGSGTATYSYDRQMDTCATVMTTVPEDDQIMSNNSVQPAWRSNYKTDSTE 1165
             :.|...|..:.|....|.::.::.::.       ::.|.|:|             :...::.|.
 Frog   940 VSRDLKRRLDSIASSQSSASSGFAEEKS-------LSDVEEED-------------AGEVSEDTC 984

  Fly  1166 AMTVTTVDLISWAFQVARGMDYLSSKKVLHGDLAARNILLCEDNVVKICDFGLARSMYRGDNYKK 1230
            ..::...||||::||||:||:|::|:|.:|.|||||||||.|:||||||||||||.:|:..:|.:
 Frog   985 KSSLCMEDLISYSFQVAKGMEYMASRKCIHRDLAARNILLAENNVVKICDFGLARDIYKDPDYVR 1049

  Fly  1231 SENGKLPIKWLALESLSDHVFSTYSDVWSYGIVLWEMFSLAKVPYPGIDPNQELFNKLNDGYRME 1295
            ..:.:||:||:|.|::.|.|::|.|||||:|::|||:|||...||||:..:::...:|.:|.||.
 Frog  1050 KGDARLPLKWMAPETIFDRVYTTQSDVWSFGVLLWEIFSLGASPYPGVQIDEDFCRRLKEGTRMR 1114

  Fly  1296 KPKFANQELYEIMLECWRKNPESRPLFAELEKRFANMLGEDV---ASHYLDLNNPYMQSNIEYMK 1357
            .|::|..|:|:.||:||..:|:.||:|:||.:...|:|...|   ...|:.|.   :..|||   
 Frog  1115 APEYATVEIYQTMLDCWHGDPQQRPVFSELVEHLGNLLQASVQQDGKDYIPLT---VSLNIE--- 1173

  Fly  1358 KQSTDYLALMGSP------DELAPAAPRYVN--------------GHIVPDIRIEELPDD--YME 1400
              ....|::..||      :|:..|...|.|              ...|.....|::|.:  ...
 Frog  1174 --DDSGLSVPTSPVSCMEEEEVCDAKFHYDNTAGLRFLHSSSKRQSRPVSVKTFEDIPVEPAVKA 1236

  Fly  1401 MSRDSDPDACTAIFSPTRLEGESSDFPDFSSETTFNFPGARQSPTLSNNLNSGSSKPLRKKNGMP 1465
            :..:|..|:...:.|.     |.....:.:.:|.| |...:||.:..:..:..|::....::|..
 Frog  1237 IQDESQTDSGMVLASE-----ELKTLQNRTDQTQF-FSILKQSKSKESVTSESSNQTSDCQSGYH 1295

  Fly  1466 TVD--VADQAPEEIPMLHRSST 1485
            :.|  .|..:.|:..:|.|:|:
 Frog  1296 SDDTEAATDSNEKTQLLQRNSS 1317

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
PvrNP_001162911.1 IG_like 346..432 CDD:214653 22/101 (22%)
Ig strand C 363..366 CDD:409353 1/2 (50%)
Ig strand E 396..400 CDD:409353 2/3 (67%)
Ig strand F 410..415 CDD:409353 0/4 (0%)
Ig strand G 425..428 CDD:409353 0/2 (0%)
Ig 458..533 CDD:472250 18/87 (21%)
Ig strand B 459..463 CDD:409353 0/3 (0%)
Ig strand C 472..476 CDD:409353 0/3 (0%)
Ig strand E 497..503 CDD:409353 1/7 (14%)
Ig strand F 513..518 CDD:409353 1/13 (8%)
Ig 671..>742 CDD:472250 22/93 (24%)
Ig strand B 674..678 CDD:409353 0/3 (0%)
Ig strand C 687..691 CDD:409353 2/3 (67%)
Ig strand E 717..721 CDD:409353 1/3 (33%)
Ig strand F 731..736 CDD:409353 2/4 (50%)
Ig 779..851 CDD:472250 22/73 (30%)
Ig strand B 781..785 CDD:409570 0/3 (0%)
Ig strand C 794..798 CDD:409570 0/3 (0%)
Ig strand E 816..821 CDD:409570 1/4 (25%)
Ig strand F 831..836 CDD:409570 2/4 (50%)
Ig strand G 844..847 CDD:409570 1/2 (50%)
Protein Kinases, catalytic domain 927..1332 CDD:473864 155/410 (38%)
kdrXP_002934715.3 Ig_3 23..95 CDD:464046 17/75 (23%)
Ig 214..313 CDD:472250 27/169 (16%)
Ig strand B 232..236 CDD:409448 1/3 (33%)
Ig strand C 247..251 CDD:409448 1/3 (33%)
Ig strand E 277..281 CDD:409448 2/3 (67%)
Ig strand F 291..296 CDD:409448 0/4 (0%)
Ig strand G 304..307 CDD:409448 0/2 (0%)
Ig 316..403 CDD:472250 20/124 (16%)
Ig strand B 335..339 CDD:409450 0/3 (0%)
Ig strand C 348..352 CDD:409450 0/3 (0%)
Ig strand E 367..371 CDD:409450 0/3 (0%)
Ig strand F 381..386 CDD:409450 1/4 (25%)
Ig strand G 396..399 CDD:409450 1/2 (50%)
Ig_3 538..631 CDD:464046 23/100 (23%)
I-set 654..731 CDD:400151 20/88 (23%)
Ig strand B 671..675 CDD:409353 0/3 (0%)
Ig strand C 684..688 CDD:409353 0/3 (0%)
Ig strand E 706..711 CDD:409353 1/4 (25%)
Ig strand F 721..726 CDD:409353 2/4 (50%)
Ig strand G 734..737 CDD:409353 0/2 (0%)
VEGFR-2_TMD 746..780 CDD:375470 9/54 (17%)
PTKc_VEGFR2 813..1155 CDD:270681 157/414 (38%)

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