DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Pvr and kdr

DIOPT Version :9

Sequence 1:NP_001162911.1 Gene:Pvr / 34127 FlyBaseID:FBgn0032006 Length:1577 Species:Drosophila melanogaster
Sequence 2:XP_002934715.3 Gene:kdr / 100487501 XenbaseID:XB-GENE-6053213 Length:1338 Species:Xenopus tropicalis


Alignment Length:1647 Identity:394/1647 - (23%)
Similarity:644/1647 - (39%) Gaps:495/1647 - (30%)


- Green bases have known domain annotations that are detailed below.


  Fly     2 AMLPRLILLPLLLILRISWSDAVPLQQFSPDPDDSIENCGGENGAPLMTPCKSAIILDAQTSTTL 66
            |:||..:||.||..|..|                         ..|.::..|..:::.|..:.|:
 Frog     3 AVLPGCLLLLLLGSLMAS-------------------------DFPSLSAKKDHLVIAANETLTI 42

  Fly    67 KCEDDEPMSW-WTSQSQYVHVKSFDN----TEDPARPFGTSLHLIEVTADYVAAYYCVKTSKFSQ 126
            .|....|::| |...    |..|.:|    :|.....:..:|.|.:|.|:....|.|.       
 Frog    43 ACRGQRPVNWSWPIN----HSNSINNRLSVSECNESSYCLTLTLTKVVANDSGIYKCY------- 96

  Fly   127 IAKEEQSDEAMIELVNQGYASSIYVYVNDPDTKLVDSHN----VVTARQYTDVVIPCKPAMPDTE 187
               .|.|:.          .:|:.|::.|..:..|.|.:    .|...:...|.:||..:.||..
 Frog    97 ---YEDSNA----------TASVRVFIRDERSPFVPSISEQLLAVYITENKTVTVPCLASKPDLN 148

  Fly   188 VLL--ETSNGEMHSSKSVGRYDPQRGFTI--EIRSIVD--------GGDYYCRPNPPFPHNEEEM 240
            |.|  :..:...|.:.:...:|.::||||  |:...|.        .|:.|..|:         .
 Frog   149 VTLCAKYPDSTFHPNGNSIHWDHKKGFTILSELLKTVSWVSCETKLNGEVYRSPS---------Y 204

  Fly   241 TSIEVRFIATGLDI-PRTQTTNMVYTYAPGVTDGDDEVLTVTNQSTGNLALIRGGDGTLSRERAR 304
            ..:.|.|....|.: |..|....|         |:...||.|..:                    
 Frog   205 FVLVVGFKIYSLSMNPHPQVQLAV---------GEKLALTCTAHT-------------------- 240

  Fly   305 RSPARLAPMNASPSPRPGQDGKPLPKPVIRSSVEHHVFTDTNFTLD----CEQSAYVESVY---- 361
                   |:|..                            .:|..|    .|:||..:.:.    
 Frog   241 -------PLNVR----------------------------VDFKWDYPAIMEKSAETKGLKKELH 270

  Fly   362 -GMEWFTPSRDENRIFASQSRT--DPKTRNSTHQTG-----RSTLTVLNAQPSDTGLYKCVTTDN 418
             |:|.       :.||...|.|  |....:.|..||     .||..:::.:|       .:|.|.
 Frog   271 GGLEL-------SGIFIIDSVTLKDRGNYSCTAYTGLMSKTSSTTVIVHEKP-------FITLDE 321

  Fly   419 SNQNVQRATYRIKVLKQNESYLNVGEPSGHYNVQEYANRTIQMTANFEGFPTPSFSWFKPDGTEV 483
            |..:|                           |.....:.:::...:..:|.|...|.|      
 Frog   322 SMDSV---------------------------VVTKVGQKVRIPVKYTAYPMPDIKWLK------ 353

  Fly   484 RQSENNFKILSTELSTMLQ--VLNAQLQ-DSGTYVL---------RGSNSFG-VVQREYNVSVMD 535
                 |.|.|...:..|:.  ::||..: |:|.|.:         :.|::|. |||....:....
 Frog   354 -----NGKPLHHPMVRMVNNLLINAASEKDAGNYTVVLSNVQTKQQESHTFHLVVQVPPKICEKA 413

  Fly   536 APALKMSDAYVQVGSVARLECTVRSYPPAIVTFFFRPCSLEPQWPTCSVLNQNFSLPSEQEKYQF 600
            .||  ..|:| :.|::..|.||....|        .|.|::.:|.    |.:..|..|    ||:
 Frog   414 VPA--PLDSY-KYGNLYILTCTASGIP--------TPVSIKWEWQ----LEEECSFSS----YQY 459

  Fly   601 QTRPRPGKLSVER---------IYEVSFLPTEPGILTCIAQNIIDGKERRTLTK----------- 645
            .....|...:..|         :.|.:...|:          :|:||. :|::|           
 Frog   460 DIGKNPYTCASWRDIFDKNGGNVIETNETRTD----------VIEGKV-KTVSKLVIHSARVSSL 513

  Fly   646 ------------AHVLLGNISENMTIYGFDKDHKIAKEDNVNFTCEALAYHFDGNLKWFINGEDL 698
                        .||:..:::..:.| ....:.|:.:.||:...|.|..:.: ||:.||      
 Frog   514 YRCSATNQAGEDEHVISFHVTRGLEI-DMQPNSKLTERDNITLICTADKFTY-GNVMWF------ 570

  Fly   699 KESDS----------------------VHIETSHTK-YSYKSTVHITTISDRDRGTYECRAYHND 740
            |.|.|                      :|..|::|. .:..|.:.:..||.|::|.|.|.|....
 Frog   571 KLSPSTVEKHHMGWPIPVCKNLVGLVRMHATTTNTNGDNVTSALVLHNISMREQGNYVCVAQDKK 635

  Fly   741 KDAVYS-SREIDL------YVHDPSAPQWTNGGQEGHSKIKRKLSQTLELECASTAVPVAIVRWF 798
            ....|. .|.|.:      :::.....|            .|.:|:|:.::|.::..|...:.||
 Frog   636 TQKKYCLIRHIRIQAQKVPFIYQDLKNQ------------TRNVSETVVVKCQASGTPDPQIIWF 688

  Fly   799 KDDKEVTESKLRHIIEKESKLLITHLYPGDEGVYKCVVENRL--DRIERSFTVVISD-------- 853
            |||..:.|.....:.:....|.|..:...|||:|.|...|.|  .:.|..|||..:|        
 Frog   689 KDDDSLVEDSGIILKDHNRTLTIQRVRKEDEGIYSCRACNDLGCTKSEMYFTVNGTDEKTNLELI 753

  Fly   854 -LPGISMAWVWFGVILFLILIGLCVFLAVRYQKEHKRHLALKAAGLANFEEGAVGHIN-----PD 912
             |.|..:..::|.|:|.:||            :..||         .|..|...|:::     .:
 Frog   754 ILVGTGIIAMFFWVLLVIIL------------RTVKR---------PNGGELKAGYLSIIMDPGE 797

  Fly   913 LTLDEQAELLPYN-REFEFPRENLKLGKQLGAGAFGVVLKGEAKGIRREEPTTTVAVKMVKATAD 976
            :.::||.|.|.|: .::||||:.|||||.||.||||.||:.:|.||.:.....||||||:|..|.
 Frog   798 VPIEEQCERLSYDASKWEFPRDRLKLGKPLGRGAFGQVLEADAFGIDKSGSCKTVAVKMLKEGAT 862

  Fly   977 NEVVRALVSELKIMVHLGQHLNVVNLLGAVTKNIAKRELMVIVEYCRFGNIQNFLLRNRKCFINQ 1041
            .....||:|||||:.|:|.||||||||||.||  ....||||||||:.||:..:|...|..|:  
 Frog   863 TSEHSALMSELKILSHIGHHLNVVNLLGACTK--PGGPLMVIVEYCKNGNLSAYLRSKRSEFV-- 923

  Fly  1042 INPDTDHIDPSIMTQRMSDNYELHRDTNGGGLKYANVGFPIHSYINEPHNNNTQPPTHRR----- 1101
                                  |::                           |:.|.:|:     
 Frog   924 ----------------------LYK---------------------------TKTPRYRKQHYVE 939

  Fly  1102 -NSDNDPRSGTRAGRTGSGTATYSYDRQMDTCATVMTTVPEDDQIMSNNSVQPAWRSNYKTDSTE 1165
             :.|...|..:.|....|.::.::.::.       ::.|.|:|             :...::.|.
 Frog   940 VSRDLKRRLDSIASSQSSASSGFAEEKS-------LSDVEEED-------------AGEVSEDTC 984

  Fly  1166 AMTVTTVDLISWAFQVARGMDYLSSKKVLHGDLAARNILLCEDNVVKICDFGLARSMYRGDNYKK 1230
            ..::...||||::||||:||:|::|:|.:|.|||||||||.|:||||||||||||.:|:..:|.:
 Frog   985 KSSLCMEDLISYSFQVAKGMEYMASRKCIHRDLAARNILLAENNVVKICDFGLARDIYKDPDYVR 1049

  Fly  1231 SENGKLPIKWLALESLSDHVFSTYSDVWSYGIVLWEMFSLAKVPYPGIDPNQELFNKLNDGYRME 1295
            ..:.:||:||:|.|::.|.|::|.|||||:|::|||:|||...||||:..:::...:|.:|.||.
 Frog  1050 KGDARLPLKWMAPETIFDRVYTTQSDVWSFGVLLWEIFSLGASPYPGVQIDEDFCRRLKEGTRMR 1114

  Fly  1296 KPKFANQELYEIMLECWRKNPESRPLFAELEKRFANMLGEDV---ASHYLDLNNPYMQSNIEYMK 1357
            .|::|..|:|:.||:||..:|:.||:|:||.:...|:|...|   ...|:.|.   :..|||   
 Frog  1115 APEYATVEIYQTMLDCWHGDPQQRPVFSELVEHLGNLLQASVQQDGKDYIPLT---VSLNIE--- 1173

  Fly  1358 KQSTDYLALMGSP------DELAPAAPRYVN--------------GHIVPDIRIEELPDD--YME 1400
              ....|::..||      :|:..|...|.|              ...|.....|::|.:  ...
 Frog  1174 --DDSGLSVPTSPVSCMEEEEVCDAKFHYDNTAGLRFLHSSSKRQSRPVSVKTFEDIPVEPAVKA 1236

  Fly  1401 MSRDSDPDACTAIFSPTRLEGESSDFPDFSSETTFNFPGARQSPTLSNNLNSGSSKPLRKKNGMP 1465
            :..:|..|:...:.|.     |.....:.:.:|.| |...:||.:..:..:..|::....::|..
 Frog  1237 IQDESQTDSGMVLASE-----ELKTLQNRTDQTQF-FSILKQSKSKESVTSESSNQTSDCQSGYH 1295

  Fly  1466 TVD--VADQAPEEIPMLHRSST 1485
            :.|  .|..:.|:..:|.|:|:
 Frog  1296 SDDTEAATDSNEKTQLLQRNSS 1317

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
PvrNP_001162911.1 IG 346..432 CDD:214652 22/101 (22%)
Ig <363..432 CDD:299845 16/75 (21%)
Ig 466..533 CDD:299845 18/79 (23%)
IG_like 672..754 CDD:214653 25/111 (23%)
Ig 674..739 CDD:143165 20/87 (23%)
IGc2 779..840 CDD:197706 17/60 (28%)
PKc_like 927..1332 CDD:304357 155/410 (38%)
Pkinase_Tyr 935..1329 CDD:285015 151/399 (38%)
kdrXP_002934715.3 Ig_3 23..95 CDD:404760 17/75 (23%)
Ig 214..313 CDD:416386 27/169 (16%)
Ig strand A 214..218 CDD:409353 1/3 (33%)
Ig strand A' 224..228 CDD:409353 0/3 (0%)
Ig strand B 230..239 CDD:409353 3/8 (38%)
Ig strand C 246..251 CDD:409353 1/4 (25%)
Ig strand D 259..267 CDD:409353 2/7 (29%)
Ig strand E 273..281 CDD:409353 3/14 (21%)
Ig strand F 291..297 CDD:409353 1/5 (20%)
Ig strand G 302..308 CDD:409353 1/5 (20%)
Ig 316..403 CDD:416386 20/124 (16%)
Ig strand A 316..319 CDD:409353 0/2 (0%)
Ig strand A' 326..330 CDD:409353 2/30 (7%)
Ig strand B 332..343 CDD:409353 0/10 (0%)
Ig strand C 347..353 CDD:409353 2/5 (40%)
Ig strand C' 355..358 CDD:409353 1/2 (50%)
Ig strand E 367..372 CDD:409353 0/4 (0%)
Ig strand F 380..388 CDD:409353 2/7 (29%)
Ig strand G 394..403 CDD:409353 2/8 (25%)
I-set 654..731 CDD:400151 20/88 (23%)
Ig strand A' 662..665 CDD:409353 1/14 (7%)
Ig strand B 671..678 CDD:409353 1/6 (17%)
Ig strand C 684..689 CDD:409353 1/4 (25%)
Ig strand C' 692..694 CDD:409353 0/1 (0%)
Ig strand D 700..704 CDD:409353 0/3 (0%)
Ig strand E 706..711 CDD:409353 1/4 (25%)
Ig strand F 720..728 CDD:409353 3/7 (43%)
Ig strand G 731..741 CDD:409353 2/9 (22%)
VEGFR-2_TMD 746..780 CDD:375470 9/54 (17%)
PTKc_VEGFR2 813..1155 CDD:270681 157/414 (38%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 299 1.000 Domainoid score I1422
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 419 1.000 Inparanoid score I1763
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D126783at33208
OrthoFinder 1 1.000 - - FOG0001573
OrthoInspector 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 1 1.000 - - X787
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
55.060

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