DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Snx6 and SNX3

DIOPT Version :9

Sequence 1:	NP_001245939.1	Gene:	Snx6 / 34126	FlyBaseID:	FBgn0032005	Length:	455	Species:	Drosophila melanogaster
Sequence 2:	NP_003786.1	Gene:	SNX3 / 8724	HGNCID:	11174	Length:	162	Species:	Homo sapiens

Alignment Length:	163	Identity:	35/163 - (21%)
Similarity:	72/163 - (44%)	Gaps:	35/163 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    54 TSPDSSSSAPATPAVLGENALHVEISD----ALSEKEKVKFTVHTRTTLPGFSKKDNNVVRQHEE 114
            |.|.:.:.|...|:    |.|.:::|:    .:.......:.:..:|.||.|..|::.|.|::.:
Human    13 TKPQNLNDAYGPPS----NFLEIDVSNPQTVGVGRGRFTTYEIRVKTNLPIFKLKESTVRRRYSD 73

  Fly   115 FVWLHDRIEENDDYAGYIIPPCPPRPDFDASREKLQRLG-EGEGNMTKEEF-KKMKSELEAEYLA 177
            |.||...:|..   :..::||.|       .:..|::|. .|:..:..:.| ::.|..||.
Human    74 FEWLRSELERE---SKVVVPPLP-------GKAFLRQLPFRGDDGIFDDNFIEERKQGLEQ---- 124

  Fly   178 TFKKTVAMHEVFLRRLASHPVFRVDQHLKVFLE 210
                       |:.::|.||:.:.::.|.:||:
Human   125 -----------FINKVAGHPLAQNERCLHMFLQ 146

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Snx6	NP_001245939.1	PX_SNX5_like	72..212	CDD:132802	31/145 (21%)
Snx6	NP_001245939.1	BAR_SNX5_6	228..452	CDD:153305
SNX3	NP_003786.1	PX_SNX3	28..150	CDD:132826	30/144 (21%)
SNX3	NP_003786.1	Binds predominantly to PtdIns(P5) and weaker to PtdIns(P3) abd PtdIns(P4), involved in neurite outgrowth regulation. /evidence=ECO:0000250\|UniProtKB:O70492	147..162		35/163 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910