DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Snx6 and Snx5

DIOPT Version :9

Sequence 1:	NP_001245939.1	Gene:	Snx6 / 34126	FlyBaseID:	FBgn0032005	Length:	455	Species:	Drosophila melanogaster
Sequence 2:	NP_001186117.1	Gene:	Snx5 / 69178	MGIID:	1916428	Length:	404	Species:	Mus musculus

Alignment Length:	376	Identity:	198/376 - (52%)
Similarity:	269/376 - (71%)	Gaps:	7/376 - (1%)

- Green bases have known domain annotations that are detailed below.

  Fly    73 ALHVEISDALSEKEKVKFTVHTRTTLPGFSKKDNNVVRQHEEFVWLHDRIEENDDYAGYIIPPCP 137
            :|.::|.|||||::||||||||:|||..|...:.:|.||||:||||||.:.|..||||.||||.|
Mouse    30 SLQIDIPDALSERDKVKFTVHTKTTLSTFQSPEFSVTRQHEDFVWLHDTLTETTDYAGLIIPPAP 94

  Fly   138 PRPDFDASREKLQRLGEGEGNMTKEEFKKMKSELEAEYLATFKKTVAMHEVFLRRLASHPVFRVD 202
            .:||||..|||:|:||||||:||||||.|||.||||||||.|||||:.|||||:||:||||...|
Mouse    95 TKPDFDGPREKMQKLGEGEGSMTKEEFAKMKQELEAEYLAVFKKTVSTHEVFLQRLSSHPVLSKD 159

  Fly   203 QHLKVFLEYDQDLCAKPRKKMAIFGGFVKSLGKTTDEILLSATVRDVNDFFENELQFLTEYHGHL 267
            ::..|||||||||..:.:....:||||.||:.|:.||:|.|. |::|:||||.|..||..|:..:
Mouse   160 RNFHVFLEYDQDLSVRRKNTKEMFGGFFKSVVKSADEVLFSG-VKEVDDFFEQEKNFLINYYNRI 223

  Fly   268 REAALRTEKMTQRHKDVGDSHQKISNALTQLSTTEKGNVETFVAKTAEIFERIKNLETRVASDQD 332
            :::..:.:|||:.||:|.|.:...:..|..|:..|...::.::.|.||:||:::.:|.||:||:|
Mouse   224 KDSCAKADKMTRSHKNVADDYIHTAACLHSLALEEPTVIKKYLLKVAELFEKLRKVEGRVSSDED 288

  Fly   333 LKLGDTLRYYQRDSDAAKALLIRRLRCLAAYEAANRNLEKARSKNKDVHAPLEVQEAETAQAEAC 397
            |||.:.||||..:.:|||.||.||.:.|..||.:|:.|:|||.|:||      |:.|||.|.|.|
Mouse   289 LKLTELLRYYMLNIEAAKDLLYRRTKALIDYENSNKALDKARLKSKD------VKLAETHQQECC 347

  Fly   398 EKFESMSACGKEELIGFRNRRVAAFKKSLVELSELEIKHAKTQYEYLRQSL 448
            :|||.:|...|||||.|:.:|||||:|:|:|:||||||||:.....|:..:
Mouse   348 QKFEQLSESAKEELINFKRKRVAAFRKNLIEMSELEIKHARNNVSLLQSCI 398

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Snx6	NP_001245939.1	PX_SNX5_like	72..212	CDD:132802	92/138 (67%)
Snx6	NP_001245939.1	BAR_SNX5_6	228..452	CDD:153305	99/221 (45%)
Snx5	NP_001186117.1	PX_domain	29..169	CDD:295365	92/138 (67%)
		Phosphatidylinositol bisphosphate binding. /evidence=ECO:0000250\|UniProtKB:B1H267	40..46		3/5 (60%)
		Phosphatidylinositol bisphosphate binding. /evidence=ECO:0000250\|UniProtKB:B1H267	99..105		3/5 (60%)
		Phosphatidylinositol bisphosphate binding. /evidence=ECO:0000250\|UniProtKB:B1H267	113..116		2/2 (100%)
		Interaction with DOCK1. /evidence=ECO:0000250\|UniProtKB:Q9Y5X3	169..261		35/92 (38%)
		Membrane-binding amphipathic helix. /evidence=ECO:0000250\|UniProtKB:Q9Y5X3	183..200		10/16 (63%)
		BAR_SNX5	185..402	CDD:153347	99/221 (45%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167845769
Domainoid	1	1.000	218	1.000	Domainoid score	I2642
eggNOG	1	0.900	-	-		E1_KOG1660
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	424	1.000	Inparanoid score	I1748
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG52498
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm43491
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR45850
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1564
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	11	10.860