DRSC/TRiP Functional Genomics Resources

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Protein Alignment Snx6 and Snx5

DIOPT Version :10

Sequence 1:NP_001245939.1 Gene:Snx6 / 34126 FlyBaseID:FBgn0032005 Length:455 Species:Drosophila melanogaster
Sequence 2:NP_077187.1 Gene:Snx5 / 69178 MGIID:1916428 Length:404 Species:Mus musculus


Alignment Length:376 Identity:198/376 - (52%)
Similarity:269/376 - (71%) Gaps:7/376 - (1%)


- Green bases have known domain annotations that are detailed below.


  Fly    73 ALHVEISDALSEKEKVKFTVHTRTTLPGFSKKDNNVVRQHEEFVWLHDRIEENDDYAGYIIPPCP 137
            :|.::|.|||||::||||||||:|||..|...:.:|.||||:||||||.:.|..||||.||||.|
Mouse    30 SLQIDIPDALSERDKVKFTVHTKTTLSTFQSPEFSVTRQHEDFVWLHDTLTETTDYAGLIIPPAP 94

  Fly   138 PRPDFDASREKLQRLGEGEGNMTKEEFKKMKSELEAEYLATFKKTVAMHEVFLRRLASHPVFRVD 202
            .:||||..|||:|:||||||:||||||.|||.||||||||.|||||:.|||||:||:||||...|
Mouse    95 TKPDFDGPREKMQKLGEGEGSMTKEEFAKMKQELEAEYLAVFKKTVSTHEVFLQRLSSHPVLSKD 159

  Fly   203 QHLKVFLEYDQDLCAKPRKKMAIFGGFVKSLGKTTDEILLSATVRDVNDFFENELQFLTEYHGHL 267
            ::..|||||||||..:.:....:||||.||:.|:.||:|.|. |::|:||||.|..||..|:..:
Mouse   160 RNFHVFLEYDQDLSVRRKNTKEMFGGFFKSVVKSADEVLFSG-VKEVDDFFEQEKNFLINYYNRI 223

  Fly   268 REAALRTEKMTQRHKDVGDSHQKISNALTQLSTTEKGNVETFVAKTAEIFERIKNLETRVASDQD 332
            :::..:.:|||:.||:|.|.:...:..|..|:..|...::.::.|.||:||:::.:|.||:||:|
Mouse   224 KDSCAKADKMTRSHKNVADDYIHTAACLHSLALEEPTVIKKYLLKVAELFEKLRKVEGRVSSDED 288

  Fly   333 LKLGDTLRYYQRDSDAAKALLIRRLRCLAAYEAANRNLEKARSKNKDVHAPLEVQEAETAQAEAC 397
            |||.:.||||..:.:|||.||.||.:.|..||.:|:.|:|||.|:||      |:.|||.|.|.|
Mouse   289 LKLTELLRYYMLNIEAAKDLLYRRTKALIDYENSNKALDKARLKSKD------VKLAETHQQECC 347

  Fly   398 EKFESMSACGKEELIGFRNRRVAAFKKSLVELSELEIKHAKTQYEYLRQSL 448
            :|||.:|...|||||.|:.:|||||:|:|:|:||||||||:.....|:..:
Mouse   348 QKFEQLSESAKEELINFKRKRVAAFRKNLIEMSELEIKHARNNVSLLQSCI 398

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Snx6NP_001245939.1 PX_SNX5_like 72..212 CDD:132802 92/138 (67%)
BAR_SNX5_6 228..452 CDD:153305 99/221 (45%)
Snx5NP_077187.1 PX_domain 29..169 CDD:470617 92/138 (67%)
Interaction with DOCK1. /evidence=ECO:0000250|UniProtKB:Q9Y5X3 169..261 35/92 (38%)
Membrane-binding amphipathic helix. /evidence=ECO:0000250|UniProtKB:Q9Y5X3 183..200 10/16 (63%)
BAR_SNX5 185..402 CDD:153347 99/221 (45%)

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