Protein Alignment Snx6 and Snx2

DIOPT Version :9

• Sequence 1: NP_001245939.1
• Gene: Snx6 / 34126
• FlyBaseID: FBgn0032005
• Length: 455
• Species: Drosophila melanogaster
• Sequence 2: NP_001344392.1
• Gene: Snx2 / 67804
• MGIID: 1915054
• Length: 523
• Species: Mus musculus
• Alignment Length: 541
• Identity: 128/541 - (23%)
• Similarity: 205/541 - (37%)
• Gaps: 147/541 - (27%)

  Fly    16 TNNGATMEIASPTNPLATPPATGGAPAPSGATNGSG---------------------SATSPD-- 57
            |:..:|:| :||::|   .||:..|...|..:|||.                     |..||:
Mouse    29 TSTVSTLE-SSPSSP---EPASLPAEDISANSNGSKPVEVVLDDDREDLFAEATEEVSLDSPERE 89

  Fly    58 ---SSSSAPA----TPAVL-------------------------GENALHVEISDALSEKEKV-- 88
               ||..:||    ||..|                         ..|....:|...:|:.|||
Mouse    90 LILSSEPSPAVTPVTPTTLIAPRIESKSISAPVIFDRSRDEIEEEANGDIFDIEIGVSDPEKVGD 154

  Fly    89 ------KFTVHTRTTLPGFSKKDNNVVRQHEEFVWLHDRIEENDDYAGYIIPPCPPRPDFDASRE 147
                  .:.|.|:|:|..|||.:.:|.|:..:|:.||.::.....:.|||:||.|.:.....::.
Mouse   155 GMNAYMAYRVTTKTSLSMFSKSEFSVKRRFSDFLGLHSKLASKYLHVGYIVPPAPEKSIVGMTKV 219

  Fly   148 KLQRLGEGEGNMTKEEF-KKMKSELEAEYLATFKKTVAMHEVFLRRLASHPVFRVDQHLKVFLEY 211
            |:     |:.:.:..|| :|.::.||.               :|:|...||....|..|:.|||.
Mouse   220 KV-----GKEDSSSTEFVEKRRAALER---------------YLQRTVKHPTLLQDPDLRQFLES 264

  Fly   212 DQDLCAKPR--KKMAIFG-GFVKSLGKTTDEILLSATVRDVNDF--------FENELQFLTEYHG 265
            .:    .||  ...|:.| |.::.:.|..|.:.......:.:|.        |||..|.|.:.|.
Mouse   265 SE----LPRAVNTQALSGAGILRMVNKAADAVNKMTIKMNESDAWFEEKQQQFENLDQQLRKLHA 325

  Fly   266 -------HLREAALRTEKMTQRHKDVGDS--HQKISNALTQLSTTEKGNVETFVAKTAEIFERIK 321
                   |.:|.:..|....:....:|:|  |..:|.||:||               ||:.|:|.
Mouse   326 SVEALVCHRKELSANTAAFAKSAAMLGNSEDHTALSRALSQL---------------AEVEEKID 375

  Fly   322 NLETRVASDQDLKLGDTLRYYQRDSDAAKALLIRRLRCLAAYEAANRNLEKAR------------ 374
            .|....|........:.|..|.|...|.|.:...|::|...:|.|...|.|.|
Mouse   376 QLHQEQAFADFYMFSELLSDYIRLIAAVKGVFDHRMKCWQKWEDAQITLLKKRETEAKMMVANKP 440

  Fly   375 -----SKNKDVHAPLEVQEAETAQAEACEKFESMSACGKEELIGFRNRRVAAFKKSLVELSELEI 434
                 :|| ::...:|..||:..|.|  ..||.:|...::|:..|...||..||..:::..|..:
Mouse   441 DKIQQAKN-EIREEIEEWEAKVQQGE--RDFEQISKTIRKEVGRFEKERVKDFKAVIIKYLESLV 502

  Fly   435 KHAKTQYEYLRQSLLALKEIA 455
            :..:...:|....|...|.||
Mouse   503 QTQQQLIKYWEAFLPEAKAIA 523

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Snx6	NP_001245939.1	PX_SNX5_like	72..212	CDD:132802	40/148 (27%)
		BAR_SNX5_6	228..452	CDD:153305	58/257 (23%)
Snx2	NP_001344392.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	30..62		12/35 (34%)
		Sorting_nexin	<49..112	CDD:308990	15/62 (24%)
		PX_SNX2	142..265	CDD:132815	39/142 (27%)
		Membrane-binding amphipathic helix. /evidence=ECO:0000250|UniProtKB:O60749	278..295		4/16 (25%)
		BAR	283..520	CDD:325158	57/254 (22%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167845768
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.840