Protein Alignment Snx6 and SNX2

DIOPT Version :9

• Sequence 1: NP_001245939.1
• Gene: Snx6 / 34126
• FlyBaseID: FBgn0032005
• Length: 455
• Species: Drosophila melanogaster
• Sequence 2: NP_003091.2
• Gene: SNX2 / 6643
• HGNCID: 11173
• Length: 519
• Species: Homo sapiens
• Alignment Length: 536
• Identity: 118/536 - (22%)
• Similarity: 211/536 - (39%)
• Gaps: 122/536 - (22%)

  Fly     3 DGTD-----DSNLLNSPSTNNGATM---EIASPTN------------------------PLATP- 34
            ||.|     .|.|.:|||:...|::   :|::.:|                        .|.:|
Human    23 DGEDLFTSTVSTLESSPSSPEPASLPAEDISANSNGPKPTEVVLDDDREDLFAEATEEVSLDSPE 87

  Fly    35 --PATGGAPAPSGATNGSGSATSPDSSSSAPATPAVLGENALHVE---------ISDALSEKEKV 88
              |.....|:|:.......:..:|...|.:.:.|.:...:...:|         |...:|:.|||
Human    88 REPILSSEPSPAVTPVTPTTLIAPRIESKSMSAPVIFDRSREEIEEEANGDIFDIEIGVSDPEKV 152

  Fly    89 --------KFTVHTRTTLPGFSKKDNNVVRQHEEFVWLHDRIEENDDYAGYIIPPCPPRPDFDAS 145
                    .:.|.|:|:|..|||.:.:|.|:..:|:.||.::.....:.|||:||.|.:.....:
Human   153 GDGMNAYMAYRVTTKTSLSMFSKSEFSVKRRFSDFLGLHSKLASKYLHVGYIVPPAPEKSIVGMT 217

  Fly   146 REKLQRLGEGEGNMTKEEF-KKMKSELEAEYLATFKKTVAMHEVFLRRLASHPVFRVDQHLKVFL 209
            :.|:     |:.:.:..|| :|.::.||.               :|:|...||....|..|:.||
Human   218 KVKV-----GKEDSSSTEFVEKRRAALER---------------YLQRTVKHPTLLQDPDLRQFL 262

  Fly   210 EYDQDLCAKPR--KKMAIFG-GFVKSLGKTTDEI-LLSATVRDVNDFFENELQFLTEYHGHLREA 270
            |..:    .||  ...|:.| |.::.:.|..|.: .::..:.:.:.:||.:.|........||:.
Human   263 ESSE----LPRAVNTQALSGAGILRMVNKAADAVNKMTIKMNESDAWFEEKQQQFENLDQQLRKL 323

  Fly   271 ALRTEKMTQRHKDV----------------GDSHQKISNALTQLSTTEKGNVETFVAKTAEIFER 319
            .:..|.:....|::                .:.|..:|.||:||               ||:.|:
Human   324 HVSVEALVCHRKELSANTAAFAKSAAMLGNSEDHTALSRALSQL---------------AEVEEK 373

  Fly   320 IKNLETRVASDQDLKLGDTLRYYQRDSDAAKALLIRRLRCLAAYEAANRNLEK---ARSKNKDVH 381
            |..|....|........:.|..|.|...|.|.:...|::|...:|.|...|.|   |.:|....:
Human   374 IDQLHQEQAFADFYMFSELLSDYIRLIAAVKGVFDHRMKCWQKWEDAQITLLKKREAEAKMMVAN 438

  Fly   382 APLEVQEAET------AQAEACEK-FESMSACGKEELIGFRNRRVAAFKKSLVELSELEIKHAKT 439
            .|.::|:|:.      |:.:..|: ||.:|...::|:..|...||..||..:::..|..::..:.
Human   439 KPDKIQQAKNEIREWEAKVQQGERDFEQISKTIRKEVGRFEKERVKDFKTVIIKYLESLVQTQQQ 503

  Fly   440 QYEYLRQSLLALKEIA 455
            ..:|....|...|.||
Human   504 LIKYWEAFLPEAKAIA 519

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Snx6	NP_001245939.1	PX_SNX5_like	72..212	CDD:132802	40/157 (25%)
		BAR_SNX5_6	228..452	CDD:153305	52/250 (21%)
SNX2	NP_003091.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..104		16/80 (20%)
		Sorting_nexin	2..134	CDD:367612	20/110 (18%)
		PX_SNX2	142..265	CDD:132815	39/142 (27%)
		Interaction with RhoG. /evidence=ECO:0000269|PubMed:20604901	260..519		60/277 (22%)
		Membrane-binding amphipathic helix. /evidence=ECO:0000303|PubMed:19816406	278..295		4/16 (25%)
		BAR	283..516	CDD:386243	51/247 (21%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165155299
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.840