DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Snx6 and SNX6

DIOPT Version :9

Sequence 1:	NP_001245939.1	Gene:	Snx6 / 34126	FlyBaseID:	FBgn0032005	Length:	455	Species:	Drosophila melanogaster
Sequence 2:	NP_689419.3	Gene:	SNX6 / 58533	HGNCID:	14970	Length:	406	Species:	Homo sapiens

Alignment Length:	379	Identity:	211/379 - (55%)
Similarity:	282/379 - (74%)	Gaps:	7/379 - (1%)

- Green bases have known domain annotations that are detailed below.

  Fly    73 ALHVEISDALSEKEKVKFTVHTRTTLPGFSKKDNNVVRQHEEFVWLHDRIEENDDYAGYIIPPCP 137
            ||.|:|||||||::||||||||:::||.|.:.:.:||||||||:||||...||:|||||||||.|
Human    31 ALQVDISDALSERDKVKFTVHTKSSLPNFKQNEFSVVRQHEEFIWLHDSFVENEDYAGYIIPPAP 95

  Fly   138 PRPDFDASREKLQRLGEGEGNMTKEEFKKMKSELEAEYLATFKKTVAMHEVFLRRLASHPVFRVD 202
            |||||||||||||:||||||:||||||.|||.||||||||.||||||||||||.|:|:||:.|.|
Human    96 PRPDFDASREKLQKLGEGEGSMTKEEFTKMKQELEAEYLAIFKKTVAMHEVFLCRVAAHPILRRD 160

  Fly   203 QHLKVFLEYDQDLCAKPRKKMAIFGGFVKSLGKTTDEILLSATVRDVNDFFENELQFLTEYHGHL 267
            .:..|||||:|||..:.:.|......|.|::.|:.|.:::|. |:||:||||:|..||.|||..:
Human   161 LNFHVFLEYNQDLSVRGKNKKEKLEDFFKNMVKSADGVIVSG-VKDVDDFFEHERTFLLEYHNRV 224

  Fly   268 REAALRTEKMTQRHKDVGDSHQKISNALTQLSTTEKGNVETFVAKTAEIFERIKNLETRVASDQD 332
            ::|:.::::||:.||...|.:.:|.::|..|.|.:..::..|..|.:|:|::.:.:|.||::|:|
Human   225 KDASAKSDRMTRSHKSAADDYNRIGSSLYALGTQDSTDICKFFLKVSELFDKTRKIEARVSADED 289

  Fly   333 LKLGDTLRYYQRDSDAAKALLIRRLRCLAAYEAANRNLEKARSKNKDVHAPLEVQEAETAQAEAC 397
            |||.|.|:||.|:|.|||.||.||.|.|..||.||:.|:|||:||||      |.:|||:|...|
Human   290 LKLSDLLKYYLRESQAAKDLLYRRSRSLVDYENANKALDKARAKNKD------VLQAETSQQLCC 348

  Fly   398 EKFESMSACGKEELIGFRNRRVAAFKKSLVELSELEIKHAKTQYEYLRQSLLAL 451
            :|||.:|...|:|||.|:.||||||:|:||||:|||:||||...:.|:..|..|
Human   349 QKFEKISESAKQELIDFKTRRVAAFRKNLVELAELELKHAKGNLQLLQNCLAVL 402

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Snx6	NP_001245939.1	PX_SNX5_like	72..212	CDD:132802	103/138 (75%)
Snx6	NP_001245939.1	BAR_SNX5_6	228..452	CDD:153305	103/224 (46%)
SNX6	NP_689419.3	Interaction with PIM1. /evidence=ECO:0000269\|PubMed:11591366	2..179		107/147 (73%)
		PX_SNX6	30..170	CDD:132825	103/138 (75%)
		Phosphatidylinositol bisphosphate binding. /evidence=ECO:0000250\|UniProtKB:B1H267	41..47		3/5 (60%)
		Phosphatidylinositol bisphosphate binding. /evidence=ECO:0000250\|UniProtKB:B1H267	100..106		5/5 (100%)
		Phosphatidylinositol bisphosphate binding. /evidence=ECO:0000250\|UniProtKB:B1H267	114..117		2/2 (100%)
		Membrane-binding amphipathic helix. /evidence=ECO:0000303\|PubMed:23085988	182..199		4/16 (25%)
		BAR_SNX6	186..403	CDD:153346	103/224 (46%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	219	1.000	Domainoid score	I2646
eggNOG	1	0.900	-	-		E1_KOG1660
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H12304
Inparanoid	1	1.050	425	1.000	Inparanoid score	I1763
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG52498
OrthoDB	1	1.010	-	-		D1009572at2759
OrthoFinder	1	1.000	-	-		FOG0004890
OrthoInspector	1	1.000	-	-		otm41438
orthoMCL	1	0.900	-	-		OOG6_105967
Panther	1	1.100	-	-	O	PTHR45850
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3071
SonicParanoid	1	1.000	-	-		X1564
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	15	14.870