DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Snx6 and snx18a

DIOPT Version :9

Sequence 1:	NP_001245939.1	Gene:	Snx6 / 34126	FlyBaseID:	FBgn0032005	Length:	455	Species:	Drosophila melanogaster
Sequence 2:	NP_001093476.1	Gene:	snx18a / 562372	ZFINID:	ZDB-GENE-070705-339	Length:	567	Species:	Danio rerio

Alignment Length:	535	Identity:	96/535 - (17%)
Similarity:	161/535 - (30%)	Gaps:	211/535 - (39%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 DGTDDSNLLNSPSTNNGATMEIASPTNPLATPPATGGAPA---------PSGATNGSGSAT---- 54
            |..|.|::.:.|....|.....            .|..|:         |.||.....|||
Zfish   121 DWDDHSSIADEPGVVGGGYRNY------------EGNGPSGYSISTSSMPRGAQQAKSSATVSRN 173

  Fly    55 ----SPDSSSSAPATPAVLGENALHVEISDAL-----------------------SEKEKVKF-- 90
                |....|...|  .||||.:..|:..|.:                       ...::.||
Zfish   174 LNRFSTFVKSGGEA--FVLGEASGFVKDGDKICVVMGQYGPEWQENPYPFSCTIDDPTKQTKFKG 236

  Fly    91 ----------TVHTRTTLPGFSKKDNNVVRQHEEFVWLHDRIEENDDYAGYIIPPCPPRPDFDAS 145
                      ..||:          :.|.|:::.|.||:.|:.|.     :.:...|..|:
Zfish   237 MKSYISYKLTPTHTQ----------SQVNRRYKHFDWLYARLVEK-----FPVISVPHIPE---- 282

  Fly   146 REKLQRLGEGEGNMTKEEFKKMKSELEAEYLATFKKTVAMHEVFLRRLASHPVF-RVD--QHLKV 207
                               |:.....|.::::..::.:..   ::..:.||||. |.|  ||...
Zfish   283 -------------------KQATGRFEEDFISKRRRGLIW---WMNHMTSHPVLARCDVFQHFLS 325

  Fly   208 FLEYDQDLCAKPRKKM---------------------------AIFGGFVKSLGKTTDE--ILLS 243
            ....|:....:.::|.                           :...|| |...|..|:  |.::
Zfish   326 CSSTDEKAWKQGKRKAEKDEMVGANFFLTISTPPAPLDLQDVESRIDGF-KVFSKKMDDSVIQVN 389

  Fly   244 ATVRDVNDFFENELQ-FLTEYHGHLREAALRTEKMTQRHKDVGDSHQKISNALTQLSTTEKGNVE 307
            ||   :::|...::. |..||                  :.||.|.:.:|.|......:....:.
Zfish   390 AT---LSEFARKQIAGFKKEY------------------QKVGQSFKYLSQAFEMDQQSYSIGLN 433

  Fly   308 TFVAKTAEIFERIKNLETRVASDQDLKLGDTLRYY----QRDSDAAKALLIRRLRCLAAYEAANR 368
            ..:|.|.|.:|.|               ||   |:    ::|.|....|       ||.|:....
Zfish   434 QAIAYTGEAYEVI---------------GD---YFVEQPKQDVDPVMDL-------LALYQGHLT 473

  Fly   369 N-----------LEKARSKNKDV-HAPLEVQEAETAQAEACE--KFESMSACGKEELIGFRNRRV 419
            |           |.|.:...|.| ...:|.|.|:..: :.|.  .|.:|:     |:..|...||
Zfish   474 NYPDIIHVQKGALTKVKESQKHVEEGKMESQHADGIR-DRCNIISFATMA-----EIQYFHQTRV 532

  Fly   420 AAFKKSLVELSELEI 434
            ..||..:....:.:|
Zfish   533 RDFKSQMQHFLQQQI 547

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Snx6	NP_001245939.1	PX_SNX5_like	72..212	CDD:132802	25/177 (14%)
Snx6	NP_001245939.1	BAR_SNX5_6	228..452	CDD:153305	49/228 (21%)
snx18a	NP_001093476.1	SH3	4..58	CDD:302595
		PX_SNX18	221..347	CDD:132819	25/166 (15%)
		BAR_SNX18	358..564	CDD:153354	49/243 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910