DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Snx6 and SNX19

DIOPT Version :9

Sequence 1:	NP_001245939.1	Gene:	Snx6 / 34126	FlyBaseID:	FBgn0032005	Length:	455	Species:	Drosophila melanogaster
Sequence 2:	XP_024304289.1	Gene:	SNX19 / 399979	HGNCID:	21532	Length:	1074	Species:	Homo sapiens

Alignment Length:	396	Identity:	89/396 - (22%)
Similarity:	154/396 - (38%)	Gaps:	107/396 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MMDGTDDS-----NLLNSPSTNNGATMEIASPTNPLATPPATGGAPAP-SGATNGSGSATSPDSS 59
            :::|.:.:     :.|....||:.::::...|...|::.|     |.| |.||......:|||.
Human   468 LLEGPEKTCPSRPSCLEKDLTNDVSSLDPTLPPVLLSSSP-----PGPLSSATFSFEPLSSPDG- 526

  Fly    60 SSAPATPAVLGENALHVEISDALSEKEK--------VKFTVHTRTTLPGFSKKD------NNVVR 110
                  |.::    .::.|:..::.:|.        ..:||...|.|.|.:...      :.|.|
Human   527 ------PVII----QNLRITGTITAREHSGTGFHPYTLYTVKYETALDGENSSGLQQLAYHTVNR 581

  Fly   111 QHEEFVWLHDRIEENDDYAGYIIPPCPPR---PDFDASREKLQRLGEGEGNMTKEEFKKMKSELE 172
            ::.||:.|..|:||..|...:|.....|:   ||...            |||..:..:..||.||
Human   582 RYREFLNLQTRLEEKPDLRKFIKNVKGPKKLFPDLPL------------GNMDSDRVEARKSLLE 634

  Fly   173 AEYLATFKKTVAMHEVFLRRLASHPVFRVDQHLKVFLEYDQDLCAKPRKKMAIFGGFVKS--LGK 235
            :               ||::|.:.|.....:.::.||..:.|      .::|    |||.  :..
Human   635 S---------------FLKQLCAIPEIANSEEVQEFLALNTD------ARIA----FVKKPFMVS 674

  Fly   236 TTDEILLSATVRDVNDFF-ENELQFLTEYHGHLREAALRTEKMTQRHK----DVGDSHQKISNAL 295
            ..|::::||.|..:...| .:|.|..||   .|.||...::..|:..|    .:..|..|||.||
Human   675 RIDKMVVSAIVDTLKTAFPRSEPQSPTE---ELSEAETESKPQTEGKKASKSRLRFSSSKISPAL 736

  Fly   296 TQLSTTEK-------GNV----------ETFVAKTAEIFERIKNLETRVASDQDLKLGDTLRYYQ 343
            :.....:|       |||          |:|:.|..::.|    ::...|.::|.:.....|...
Human   737 SVTEAQDKILYCLQEGNVESETLSMSAMESFIEKQTKLLE----MQPTKAPEKDPEQPPKGRVDS 797

  Fly   344 RDSDAA 349
            ..||||
Human   798 CVSDAA 803

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Snx6	NP_001245939.1	PX_SNX5_like	72..212	CDD:132802	33/156 (21%)
Snx6	NP_001245939.1	BAR_SNX5_6	228..452	CDD:153305	38/146 (26%)
SNX19	XP_024304289.1	PXA	95..272	CDD:214611
		FtsK	<270..>332	CDD:332908
		PX_SNX19	532..659	CDD:132803	33/153 (22%)
		Nexin_C	931..1027	CDD:312222
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910