DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Snx6 and SNX5

DIOPT Version :9

Sequence 1:	NP_001245939.1	Gene:	Snx6 / 34126	FlyBaseID:	FBgn0032005	Length:	455	Species:	Drosophila melanogaster
Sequence 2:	NP_055241.1	Gene:	SNX5 / 27131	HGNCID:	14969	Length:	404	Species:	Homo sapiens

Alignment Length:	376	Identity:	197/376 - (52%)
Similarity:	270/376 - (71%)	Gaps:	7/376 - (1%)

- Green bases have known domain annotations that are detailed below.

  Fly    73 ALHVEISDALSEKEKVKFTVHTRTTLPGFSKKDNNVVRQHEEFVWLHDRIEENDDYAGYIIPPCP 137
            :|.::|.|||||::||||||||:||||.|...:.:|.||||:||||||.:.|..||||.||||.|
Human    30 SLQIDIPDALSERDKVKFTVHTKTTLPTFQSPEFSVTRQHEDFVWLHDTLIETTDYAGLIIPPAP 94

  Fly   138 PRPDFDASREKLQRLGEGEGNMTKEEFKKMKSELEAEYLATFKKTVAMHEVFLRRLASHPVFRVD 202
            .:||||..|||:|:||||||:||||||.|||.||||||||.|||||:.|||||:||:||||...|
Human    95 TKPDFDGPREKMQKLGEGEGSMTKEEFAKMKQELEAEYLAVFKKTVSSHEVFLQRLSSHPVLSKD 159

  Fly   203 QHLKVFLEYDQDLCAKPRKKMAIFGGFVKSLGKTTDEILLSATVRDVNDFFENELQFLTEYHGHL 267
            ::..|||||||||..:.:....:||||.||:.|:.||:|.:. |::|:||||.|..||..|:..:
Human   160 RNFHVFLEYDQDLSVRRKNTKEMFGGFFKSVVKSADEVLFTG-VKEVDDFFEQEKNFLINYYNRI 223

  Fly   268 REAALRTEKMTQRHKDVGDSHQKISNALTQLSTTEKGNVETFVAKTAEIFERIKNLETRVASDQD 332
            :::.::.:|||:.||:|.|.:...:..|..|:..|...::.::.|.||:||:::.:|.||:||:|
Human   224 KDSCVKADKMTRSHKNVADDYIHTAACLHSLALEEPTVIKKYLLKVAELFEKLRKVEGRVSSDED 288

  Fly   333 LKLGDTLRYYQRDSDAAKALLIRRLRCLAAYEAANRNLEKARSKNKDVHAPLEVQEAETAQAEAC 397
            |||.:.||||..:.:|||.||.||.:.|..||.:|:.|:|||.|:||      |:.||..|.|.|
Human   289 LKLTELLRYYMLNIEAAKDLLYRRTKALIDYENSNKALDKARLKSKD------VKLAEAHQQECC 347

  Fly   398 EKFESMSACGKEELIGFRNRRVAAFKKSLVELSELEIKHAKTQYEYLRQSL 448
            :|||.:|...|||||.|:.:|||||:|:|:|:||||||||:.....|:..:
Human   348 QKFEQLSESAKEELINFKRKRVAAFRKNLIEMSELEIKHARNNVSLLQSCI 398

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Snx6	NP_001245939.1	PX_SNX5_like	72..212	CDD:132802	93/138 (67%)
Snx6	NP_001245939.1	BAR_SNX5_6	228..452	CDD:153305	97/221 (44%)
SNX5	NP_055241.1	PX_SNX5	29..169	CDD:132824	93/138 (67%)
		Phosphatidylinositol bisphosphate binding. /evidence=ECO:0000250\|UniProtKB:B1H267	40..46		3/5 (60%)
		Phosphatidylinositol bisphosphate binding. /evidence=ECO:0000250\|UniProtKB:B1H267	99..105		3/5 (60%)
		Phosphatidylinositol bisphosphate binding. /evidence=ECO:0000250\|UniProtKB:B1H267	113..116		2/2 (100%)
		Interaction with DOCK1. /evidence=ECO:0000269\|PubMed:18596235	169..261		34/92 (37%)
		Membrane-binding amphipathic helix. /evidence=ECO:0000303\|PubMed:23085988	183..200		10/16 (63%)
		BAR_SNX5	185..402	CDD:153347	97/221 (44%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165155300
Domainoid	1	1.000	219	1.000	Domainoid score	I2646
eggNOG	1	0.900	-	-		E1_KOG1660
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	425	1.000	Inparanoid score	I1763
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG52498
OrthoDB	1	1.010	-	-		D1009572at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm41438
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR45850
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1564
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	12	11.870