DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Snx6 and SNX33

DIOPT Version :9

Sequence 1:	NP_001245939.1	Gene:	Snx6 / 34126	FlyBaseID:	FBgn0032005	Length:	455	Species:	Drosophila melanogaster
Sequence 2:	NP_695003.1	Gene:	SNX33 / 257364	HGNCID:	28468	Length:	574	Species:	Homo sapiens

Alignment Length:	362	Identity:	72/362 - (19%)
Similarity:	130/362 - (35%)	Gaps:	79/362 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly   108 VVRQHEEFVWLHDRIEENDDYAGYIIPPCPPRPDFDASREKLQRLGEGEGNMTKEEFKKMKSELE 172
            |.|:::.|.||::|:...     :.:...|..|:..|:           |...::..:|.|..|
Human   263 VYRRYKHFDWLYNRLLHK-----FTVISVPHLPEKQAT-----------GRFEEDFIEKRKRRL- 310

  Fly   173 AEYLATFKKTVAMHEVFLRRLASHPVFRVDQHLKVFLEYDQDLCAKPRKKMAIFGGFVKSLGKTT 237
                          .:::..:.||||....:..:.||....|...|..|:.|           ..
Human   311 --------------ILWMDHMTSHPVLSQYEGFQHFLSCLDDKQWKMGKRRA-----------EK 350

  Fly   238 DEILLSATVRDVNDFFENELQFLTEYHGHLREAALRTEKMTQRHKDVGDSHQKISNALTQLSTTE 302
            ||:        |...|....|..|| |..|::...|.:......|.:.||..::|...::|....
Human   351 DEM--------VGASFLLTFQIPTE-HQDLQDVEDRVDTFKAFSKKMDDSVLQLSTVASELVRKH 406

  Fly   303 KGNVETFVAKTAEIFERIKN---LETRVASDQ-DLKLGDTLRYY----QRDSDAAKALLIRRLRC 359
            .|.......|....|:.|.:   ::....|:. :..:..|.|.|    :..::..|..|.:.|..
Human   407 VGGFRKEFQKLGSAFQAISHSFQMDPPFCSEALNSAISHTGRTYEAIGEMFAEQPKNDLFQMLDT 471

  Fly   360 LAAYEAANRNLEKARSKNKDVHAPLEVQEAETAQAEACEKFESMSACGKEELIGFRNR-RVAAFK 423
            |:.|:....|.       .|:   :.:|:...|:.:..::........::|..|.|.| ||..|.
Human   472 LSLYQGLLSNF-------PDI---IHLQKGAFAKVKESQRMSDEGRMVQDEADGIRRRCRVVGFA 526

  Fly   424 KSLVELS------ELEIKHAKTQYEYLRQSLLALKEI 454
            .. .|::      ||:.||  ....||||.:|..:.:
Human   527 LQ-AEMNHFHQRRELDFKH--MMQNYLRQQILFYQRV 560

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Snx6	NP_001245939.1	PX_SNX5_like	72..212	CDD:132802	19/103 (18%)
Snx6	NP_001245939.1	BAR_SNX5_6	228..452	CDD:153305	49/238 (21%)
SNX33	NP_695003.1	SH3_SNX33	4..58	CDD:212829
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	68..119
		PX_domain	230..354	CDD:295365	25/140 (18%)
		BAR_SNX33	365..571	CDD:153353	44/210 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165155292
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.840