DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Snx6 and vps17

DIOPT Version :9

Sequence 1:	NP_001245939.1	Gene:	Snx6 / 34126	FlyBaseID:	FBgn0032005	Length:	455	Species:	Drosophila melanogaster
Sequence 2:	NP_593047.1	Gene:	vps17 / 2543324	PomBaseID:	SPAPJ696.01c	Length:	549	Species:	Schizosaccharomyces pombe

Alignment Length:	513	Identity:	114/513 - (22%)
Similarity:	199/513 - (38%)	Gaps:	135/513 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 TDDSNLLNSPSTNNG-ATMEIASPTN-PLATPPATGGAPAPS------GATNGSGSATS------ 55
            |||  |:||...:.| :|::.....: |:.|......:..||      |:.||:.:.|.
pombe     7 TDD--LMNSHVFSGGFSTLDDKGFQDVPIHTDMPGSISVEPSSEDANVGSVNGNINETPVFEADR 69

  Fly    56 --PDSSSSAPATPAVLGENA---------LHVEISDALSEKEK---VKFTVHTRTTLPGF-SKKD 105
              .:::.:..|..:..|||:         |.:.|.|..:|..|   :|..|  :||||.: ||..
pombe    70 LIAEATMNPSAASSTTGENSISQTGSGPFLRIRIVDIEAENSKDPVIKMNV--QTTLPAYRSKLY 132

  Fly   106 NNVVRQHEEFVWLHDRIEENDDYAGYII---PPC--PPRPDFDASREKLQRLGEGEGNMTKEEFK 165
            .||.|.|.||          ..:|.|:|   |.|  |..|:...|      :..|    .||:..
pombe   133 KNVRRTHAEF----------KKFAKYLISTHPECLIPAVPEAKTS------VSSG----IKEDLI 177

  Fly   166 KMKSELEAEYLATFKKTVAMHEVFLRRLASHPVFRVDQHLKVFLEYDQDL-----CAKPR---KK 222
            .:||.|::               :|..::::|....|..|::|:|.|...     ...|.   |:
pombe   178 YLKSGLQS---------------WLNYVSTNPNLLYDPELQLFVESDYGYSPLINTGNPTSGLKR 227

  Fly   223 MAIFGGFVKSLGKTTDEILLSATVRD-VNDFFENELQFLTEYHGHLREAALRTEKMTQRHKDVGD 286
            .|:     |......|.....|.:|. |..|::|           .::|.::.||:..|.:.:..
pombe   228 KAL-----KQFPLPPDPCQALANLRPIVKSFYKN-----------AKDAEIKLEKLVNRKQSLAL 276

  Fly   287 SHQKISNALTQLSTTEKGN-VETFVAKTAEIFERIKNLETRVASDQDLKLGDTLRYYQRDSDAAK 350
            :|..:..:|...|..|:.| :...:.:..::.:.|.::....:|.|.:.|.|:|.|...::...|
pombe   277 THADLGQSLIDYSVEEQHNGLANALNRVGKMLQAISDVRIMQSSKQLVTLADSLCYASDNAFVVK 341

  Fly   351 ALLIRR---LRCLAA--------YEAANR-----NLEKARSKNKDVHAPLEVQEAETAQAEACEK 399
            .:|..|   :|.|.:        ..||||     .:.|||:  .|....|||       |...||
pombe   342 EILSNRHILMRDLISSKNQTNSYLSAANRLQDSPKISKART--DDALQALEV-------ARVHEK 397

  Fly   400 FESMSACGKEELIGFRNRRVAAFKKSLVELSELEIKHAKTQY----EYLRQSLLALKE 453
            ..|       :.:.|....:....|:..:.:.:.::.|..:|    .|..:.||::.|
pombe   398 LLS-------DKVDFVTLNLVKESKTYTKKTSVSLQKAIREYVEKEAYYERRLLSIME 448

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Snx6	NP_001245939.1	PX_SNX5_like	72..212	CDD:132802	40/157 (25%)
Snx6	NP_001245939.1	BAR_SNX5_6	228..452	CDD:153305	50/245 (20%)
vps17	NP_593047.1	PX_Vps17p	73..209	CDD:132801	43/172 (25%)
vps17	NP_593047.1	BAR	224..453	CDD:299863	53/257 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	0	0.000