DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Snx6 and vps5

DIOPT Version :9

Sequence 1:	NP_001245939.1	Gene:	Snx6 / 34126	FlyBaseID:	FBgn0032005	Length:	455	Species:	Drosophila melanogaster
Sequence 2:	NP_587929.1	Gene:	vps5 / 2539552	PomBaseID:	SPCPJ732.01	Length:	576	Species:	Schizosaccharomyces pombe

Alignment Length:	489	Identity:	109/489 - (22%)
Similarity:	191/489 - (39%)	Gaps:	101/489 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 TDDSNLLNSPSTNNGATMEIASPTNPLATPPATGGAPAPSGATNGSGSATSPDSSSSAP-ATPAV 68
            |::..:.||..|.:  |::.||.    :.|..|....:.|....||.|.|..::..:.| |.|..
pombe   140 TENPTIPNSEQTVD--TLDAASS----SAPNFTHTVSSASSQKQGSTSLTDTENQKAHPAAAPQS 198

  Fly    69 LGENALHVEISDALSEKEKVK----FTVHTRT---TLPGFSKKDNNVVRQHEEFVWLHDRIEEND 126
            |  ...::::.|..:.||..|    ::|.||.   ..|..|  :..|.|::.:|.:|:..:..|
pombe   199 L--TPFYIQVHDPHTVKEITKSHTVYSVSTRLEEHNQPSVS--NVTVQRRYNDFAFLYQLLSNN- 258

  Fly   127 DYAGYIIPPCPPRPDFDASREKLQRLGEGEGNMTKEEFKKMKSELEAEYLATFKKTVAMHEVFLR 191
             :.|.||||.|.                          |::....:.|::   ::..|..||.||
pombe   259 -HPGCIIPPIPE--------------------------KQVVGRFDDEFI---EQRRAALEVMLR 293

  Fly   192 RLASHPVFRVDQHLKVFLEYDQ------------DLCAKPRKKMAIFGGFVKSLGKT-------- 236
            ::::|||.|.|...|:|||.:.            :..:.|.:......|.:.|....
pombe   294 KISAHPVLRDDYSFKLFLEAETFDPRMTHRTTLIESSSSPLRSGPSTSGLLDSFTSAFHTSGSSK 358

  Fly   237 ---TDEILLSATVRDVNDFFENELQFLTEYHGHLREAALRTEKMTQRHKDVGDSHQKISNALTQL 298
               .|.||:.|  :|..|..|.:|:  :.||..|.....|.:..:..| |.|::...:|  |..|
pombe   359 FSEQDPILIEA--KDTLDSLETQLK--SVYHALLLSIDQRIQFASAIH-DFGEAVGNLS--LVDL 416

  Fly   299 STTEKGNVETFVAKTAEIFERIKNLETRVASDQDLKLGDTLRYYQRDSDAAKALLIRRLR----- 358
            ..|.....:..    :::...::.::.|..:..:|.||.||..|.|..::||.....|.:
pombe   417 EPTLSSKFDGL----SQLQVELRFVQERKVAQDNLTLGTTLEEYIRYVESAKNAFTTRQKLWQTW 477

  Fly   359 --CLAAYEAANRNLEKARSKNKDVHAPLEVQEAETAQAEACEKFESMSACGKEELIGFRNRRVAA 421
              .:.|...|...|||.:.:.|.....|...|      |..||:.:.:|..::|.    :.....
pombe   478 QSSVQAVSRAKTQLEKCKKQAKSQQKSLPYLE------EQYEKYRAKAADLEKEF----SESTTL 532

  Fly   422 FKKSLVELSELEIKHAKTQYE-YLRQSLLALKEI 454
            .|:.|..|:...:...|...| :|..::.:.|||
pombe   533 LKRDLSSLTTSRVDDLKASVETWLESAIESQKEI 566

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Snx6	NP_001245939.1	PX_SNX5_like	72..212	CDD:132802	36/146 (25%)
Snx6	NP_001245939.1	BAR_SNX5_6	228..452	CDD:153305	51/242 (21%)
vps5	NP_587929.1	COG5391	59..576	CDD:227680	109/489 (22%)
		PX_Vps5p	202..314	CDD:132771	36/144 (25%)
		BAR_Vps5p	361..576	CDD:153311	52/227 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	2	1.870