DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Snx6 and Snx18

DIOPT Version :9

Sequence 1:	NP_001245939.1	Gene:	Snx6 / 34126	FlyBaseID:	FBgn0032005	Length:	455	Species:	Drosophila melanogaster
Sequence 2:	NP_570614.2	Gene:	Snx18 / 170625	MGIID:	2137642	Length:	615	Species:	Mus musculus

Alignment Length:	536	Identity:	101/536 - (18%)
Similarity:	188/536 - (35%)	Gaps:	165/536 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 DGTDDS----------------NLLNSPSTNNGAT--------MEIASPTNPLATPPATGGAPAP 43
            |..|||                :|..|.|...||.        .:::..:..::.|||...:.|.
Mouse   147 DEWDDSSTVADEPGALGSGAYPDLDGSSSAGGGAAGRYRLSTRSDLSLGSRGVSAPPAHQASGAK 211

  Fly    44 SGAT---NGSGSATSPDSSSSAPATPAVLGENALHVEISDAL----------------------- 82
            |.||   |.:..:|...|...|    .||||.:..|:..|.|
Mouse   212 SSATVSRNLNRFSTFVKSGGEA----FVLGEASGFVKDGDKLCVVLGPYGPEWQENPYPFQCTID 272

  Fly    83 SEKEKVKF----------TVHTRTTLPGFSKKDNNVVRQHEEFVWLHDRIEENDDYAGYIIPPCP 137
            ...::.||          .|.|.|.:|        |.|:::.|.||:.|:.|.     :.:...|
Mouse   273 DPTKQTKFKGMKSYISYKLVPTHTQVP--------VHRRYKHFDWLYARLAEK-----FPVISVP 324

  Fly   138 PRPDFDASREKLQRLGEGEGNMTKEEFKKMKSELEAEYLATFKKTVAMHEVFLRRLASHPVFR-- 200
            ..|:                       |:.....|.::::..:|.:..   ::..:|||||..
Mouse   325 HLPE-----------------------KQATGRFEEDFISKRRKGLIW---WMNHMASHPVLAQC 363

  Fly   201 -VDQHLKVFLEYDQDLCAKPRKKMA-----IFGGFVKSLGKTTDEILLSATVRDVNDFFENELQF 259
             |.||.........:...|..|:.|     :...|..:|...      .|...|:.: .|:::..
Mouse   364 DVFQHFLTCPSSTDEKAWKQGKRKAEKDEMVGANFFLTLSTP------PAAALDLQE-VESKIDG 421

  Fly   260 LTEYHGHLREAALR---TEKMTQRHKDVG--DSHQKISNALTQLSTTEKGNVETF-------VAK 312
            ...:...:.::||:   |.....|.:..|  ..:||:..:...||...:.:.:.|       :|.
Mouse   422 FKCFTKKMDDSALQLNHTANEFARKQVTGFKKEYQKVGQSFRGLSQAFELDQQAFSVGLNQAIAF 486

  Fly   313 TAEIFERIKNL---ETRVASDQDL-KLGDTLRYYQRDSDAAKALLIRRLRCLAAYEAANRNLEKA 373
            |.:.::.|..|   :.|    ||| .:.|.|..||........::..:...|...:.:.|::|:.
Mouse   487 TGDAYDAIGELFAEQPR----QDLDPVMDLLALYQGHLANFPDIIHVQKGALTKVKESRRHVEEG 547

  Fly   374 RSKNKDVHAPLEVQEAETAQAEACEKFESMSACGKEELIGFRNRRVAAFKKSLVELSELEIKHAK 438
            :         :|||:|:..|    ::..::|.....|:..|...||..||.        :::|
Mouse   548 K---------MEVQKADGIQ----DRCNTISFATLAEIHHFHQIRVRDFKS--------QMQH-- 589

  Fly   439 TQYEYLRQSLLALKEI 454
                :|:|.::..:::
Mouse   590 ----FLQQQIIFFQKV 601

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Snx6	NP_001245939.1	PX_SNX5_like	72..212	CDD:132802	29/175 (17%)
Snx6	NP_001245939.1	BAR_SNX5_6	228..452	CDD:153305	45/239 (19%)
Snx18	NP_570614.2	SH3_SNX18	4..58	CDD:212830
		PX_SNX18	267..394	CDD:132819	29/165 (18%)
		BAR_SNX18	406..612	CDD:153354	43/228 (19%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910