DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Snx6 and AgaP_AGAP004487

DIOPT Version :9

Sequence 1:	NP_001245939.1	Gene:	Snx6 / 34126	FlyBaseID:	FBgn0032005	Length:	455	Species:	Drosophila melanogaster
Sequence 2:	XP_313785.3	Gene:	AgaP_AGAP004487 / 1274634	VectorBaseID:	AGAP004487	Length:	424	Species:	Anopheles gambiae

Alignment Length:	454	Identity:	330/454 - (72%)
Similarity:	370/454 - (81%)	Gaps:	31/454 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MMDGTDDSNLLNSPSTNNGATMEIASPTNPLATPPATGGAPAPSGATNGSGSATSPDSSSSAPAT 65
            ||||.::          ||:..:..||:   .|.|.|.|  :..|:..| ||.|         .|
Mosquito     1 MMDGIEE----------NGSPQQATSPS---VTVPETIG--SRQGSVEG-GSTT---------GT 40

  Fly    66 PAVLGENALHVEISDALSEKEKVKFTVHTRTTLPGFSKKDNNVVRQHEEFVWLHDRIEENDDYAG 130
            .|.|.||:|.|:|||||||||:|||||||||.||||.|.|..||||||||||||||.|||::|||
Mosquito    41 TAALPENSLLVDISDALSEKERVKFTVHTRTNLPGFDKSDFLVVRQHEEFVWLHDRFEENEEYAG 105

  Fly   131 YIIPPCPPRPDFDASREKLQRLGEGEGNMTKEEFKKMKSELEAEYLATFKKTVAMHEVFLRRLAS 195
            ||||||||||||||||||||||||||||||||||||||.|||||||||||||||||||||.||||
Mosquito   106 YIIPPCPPRPDFDASREKLQRLGEGEGNMTKEEFKKMKLELEAEYLATFKKTVAMHEVFLTRLAS 170

  Fly   196 HPVFRVDQHLKVFLEYDQDLCAKPRKKMAIFGGFVKSLGKTTDEILLSATVRDVNDFFENELQFL 260
            |||||.|.||||||.||||||||.:||:.||||.|||:|||||||.|.|||:|||||||:|||||
Mosquito   171 HPVFREDSHLKVFLVYDQDLCAKMKKKIDIFGGLVKSIGKTTDEIYLGATVKDVNDFFEHELQFL 235

  Fly   261 TEYHGHLREAALRTEKMTQRHKDVGDSHQKISNALTQLSTTEKGNVETFVAKTAEIFERIKNLET 325
            .|||.||:|||:||||||.:||||.|||.:||:.|..|||.|.|::|.|:|||::|||:|:|:|.
Mosquito   236 GEYHSHLKEAAIRTEKMTNKHKDVADSHVRISSQLLALSTAEHGSMEKFLAKTSDIFEKIRNMEG 300

  Fly   326 RVASDQDLKLGDTLRYYQRDSDAAKALLIRRLRCLAAYEAANRNLEKARSKNKDVHAPLEVQEAE 390
            |||||||||||||||||||||:|||||||||||||||||||||||||||:|||||||      ||
Mosquito   301 RVASDQDLKLGDTLRYYQRDSNAAKALLIRRLRCLAAYEAANRNLEKARAKNKDVHA------AE 359

  Fly   391 TAQAEACEKFESMSACGKEELIGFRNRRVAAFKKSLVELSELEIKHAKTQYEYLRQSLLALKEI 454
            :||.:||||||||||.|||||:.||.||||||||||.:|:||||||||.|||:||||||||:|:
Mosquito   360 SAQTQACEKFESMSARGKEELVSFRLRRVAAFKKSLTDLAELEIKHAKGQYEFLRQSLLALQEL 423

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Snx6	NP_001245939.1	PX_SNX5_like	72..212	CDD:132802	122/139 (88%)
Snx6	NP_001245939.1	BAR_SNX5_6	228..452	CDD:153305	172/223 (77%)
AgaP_AGAP004487	XP_313785.3	PX_SNX5_like	47..187	CDD:132802	122/139 (88%)
AgaP_AGAP004487	XP_313785.3	BAR_SNX5_6	203..421	CDD:153305	172/223 (77%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	311	1.000	Domainoid score	I3476
eggNOG	1	0.900	-	-		E1_KOG1660
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H12304
Inparanoid	1	1.050	624	1.000	Inparanoid score	I2265
OMA	1	1.010	-	-		QHG52498
OrthoDB	1	1.010	-	-		D1009572at2759
OrthoFinder	1	1.000	-	-		FOG0004890
OrthoInspector	1	1.000	-	-		oto108820
Panther	1	1.100	-	-	LDO	PTHR45850
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X1564
TreeFam	1	0.960	-	-
	13	12.940