DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Su(var)205 and CDYL

DIOPT Version :9

Sequence 1:	NP_476755.1	Gene:	Su(var)205 / 34119	FlyBaseID:	FBgn0003607	Length:	206	Species:	Drosophila melanogaster
Sequence 2:	NP_001355054.1	Gene:	CDYL / 9425	HGNCID:	1811	Length:	598	Species:	Homo sapiens

Alignment Length:	179	Identity:	47/179 - (26%)
Similarity:	84/179 - (46%)	Gaps:	36/179 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 DNP-ESSAKVSDAE---EEEEEYAVEKIIDRRV-RKGKVEYYLKWKGYPETENTWEPENNL-DCQ 64
            |.| :.|..||..:   ::.....||:|:|:|. :|||.||.::||||...::|||||.:| :|:
Human    39 DGPSDPSISVSSEQSGAQQPPALQVERIVDKRKNKKGKTEYLVRWKGYDSEDDTWEPEQHLVNCE 103

  Fly    65 DLIQQYEASRKDEEKSAASKKDRPSSSAKAKETQGRASSSTST---------------------A 108
            :.|..:.....:::|.:...:...:|...|::...|:::|..:                     |
Human   104 EYIHDFNRRHTEKQKESTLTRTNRTSPNNARKQISRSTNSNFSKTSPKALVIGKDHESKNSQLFA 168

  Fly   109 SKRKSEEPTAPSGNKSKRTTDAEQDTI-------PVSGSTGFDRGLEAE 150
            :.:|..:.|||| ..|::..|..:..|       ||...|..| |.::|
Human   169 ASQKFRKNTAPS-LSSRKNMDLAKSGIKILVPKSPVKSRTAVD-GFQSE 215

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Su(var)205	NP_476755.1	CHROMO	24..72	CDD:237991	22/49 (45%)
Su(var)205	NP_476755.1	ChSh	141..202	CDD:197638	4/10 (40%)
CDYL	NP_001355054.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..76		11/36 (31%)
		Interaction with EZH2. /evidence=ECO:0000269\|PubMed:22009739	61..309		42/157 (27%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	112..149		5/36 (14%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	204..226		4/13 (31%)
		Acetyl-CoA-binding domain. /evidence=ECO:0000255	362..594
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1911
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810