DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Su(var)205 and CBX7

DIOPT Version :9

Sequence 1:	NP_476755.1	Gene:	Su(var)205 / 34119	FlyBaseID:	FBgn0003607	Length:	206	Species:	Drosophila melanogaster
Sequence 2:	NP_783640.1	Gene:	CBX7 / 23492	HGNCID:	1557	Length:	251	Species:	Homo sapiens

Alignment Length:	109	Identity:	41/109 - (37%)
Similarity:	57/109 - (52%)	Gaps:	8/109 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly    21 EEEYAVEKIIDRRVRKGKVEYYLKWKGYPETENTWEPENNLDCQDLIQQYEASRKDEEKSAASKK 85
            |:.:|||.|..:|||||||||.:||||:|...:|||||.::....|:..||   :.||:..||..
Human     8 EQVFAVESIRKKRVRKGKVEYLVKWKGWPPKYSTWEPEEHILDPRLVMAYE---EKEERDRASGY 69

  Fly    86 DRPSSSAKAKETQGRASSSTSTASKRKSEEP-----TAPSGNKS 124
            .:.....|....|...|....::.|.|.:|.     |.|.|:.|
Human    70 RKRGPKPKRLLLQRLYSMDLRSSHKAKGKEKLCFSLTCPLGSGS 113

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Su(var)205	NP_476755.1	CHROMO	24..72	CDD:237991	25/47 (53%)
Su(var)205	NP_476755.1	ChSh	141..202	CDD:197638
CBX7	NP_783640.1	CD_Cbx7	7..62	CDD:349293	27/56 (48%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	190..220
		CBX7_C	209..240	CDD:407338
		Required for cellular lifespan extension	223..236
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0.928771	Normalized mean entropy	S3980
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1628171at2759
OrthoFinder	1	1.000	-	-		FOG0000191
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.870