DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Su(var)205 and Cdyl

DIOPT Version :9

Sequence 1:	NP_476755.1	Gene:	Su(var)205 / 34119	FlyBaseID:	FBgn0003607	Length:	206	Species:	Drosophila melanogaster
Sequence 2:	NP_034011.1	Gene:	Cdyl / 12593	MGIID:	1339956	Length:	593	Species:	Mus musculus

Alignment Length:	185	Identity:	50/185 - (27%)
Similarity:	86/185 - (46%)	Gaps:	42/185 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 ESSAKVSDAEEEEEEYAVEKIIDRRV-RKGKVEYYLKWKGYPETENTWEPENNL-DCQDLIQQYE 71
            ::|..:.|||.:     ||.|:|:|. :|||.||.::||||...::|||||.:| :|::.|..:.
Mouse    46 QASPAIQDAETQ-----VESIVDKRKNKKGKTEYLVRWKGYDSEDDTWEPEQHLVNCEEYIHDFN 105

  Fly    72 ASRKDEEKSAASKKDRPSSSAKAKETQGRASSSTST---------------------ASKRKSEE 115
            ....:.:|..:..:...:|.:.|::...|::.||.:                     |:.:|..:
Mouse   106 RRHNERQKEGSLARASRASPSNARKQISRSTHSTLSKTNSKALVVGKDHESKSSQLLAASQKFRK 170

  Fly   116 PTAPSGNKSKRTTDAEQDTI-------PVSGSTGFD--RGLEAEKI----LGASD 157
            ..||| ..:::..|..:..|       ||.|.|..|  :|...||:    .||.|
Mouse   171 NPAPS-LANRKNMDLAKSGIKILVPKSPVKGRTSVDGFQGESPEKLDPVDQGAED 224

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Su(var)205	NP_476755.1	CHROMO	24..72	CDD:237991	22/49 (45%)
Su(var)205	NP_476755.1	ChSh	141..202	CDD:197638	8/23 (35%)
Cdyl	NP_034011.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..30
		CHROMO	55..109	CDD:214605	23/58 (40%)
		Interaction with EZH2. /evidence=ECO:0000250\|UniProtKB:Q9Y232	56..304		46/175 (26%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	110..158		6/47 (13%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	200..223		7/22 (32%)
		crotonase-like	339..535	CDD:119339
		Acetyl-CoA-binding domain. /evidence=ECO:0000255	357..589
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1911
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810