DRSC/TRiP Functional Genomics Resources

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Protein Alignment CG8419 and TRIM45

DIOPT Version :9

Sequence 1:NP_609193.1 Gene:CG8419 / 34118 FlyBaseID:FBgn0031999 Length:921 Species:Drosophila melanogaster
Sequence 2:NP_079464.2 Gene:TRIM45 / 80263 HGNCID:19018 Length:580 Species:Homo sapiens


Alignment Length:608 Identity:182/608 - (29%)
Similarity:278/608 - (45%) Gaps:77/608 - (12%)


- Green bases have known domain annotations that are detailed below.


  Fly   308 CGICLDVYTDPRTLHCLHSFCLQCLVSENFKDESLWDQDQARSEEPSNYSLRSEMGGSSAELTAT 372
            |.:||.::..||.|.|||:.|..||                  |:...:|:....||.       
Human    29 CPLCLGLFKAPRLLPCLHTVCTTCL------------------EQLEPFSVVDIRGGD------- 68

  Fly   373 VSPARQRGSSFTLRRKKSMDRLVIRSKSDGKRSTSSIGTRFTGSFASEVSTRCIRCHTCNYPTDL 437
             |.....||.|...:.:|:.              |.||               |.|..|:...||
Human    69 -SDTSSEGSIFQELKPRSLQ--------------SQIG---------------ILCPVCDAQVDL 103

  Fly   438 SLGGVRQLPQNYLLVRRIEVLRLQA-GEDVISRVWCSLCTEEISATYHCISCTLNLCTLCKEAHE 501
            .:|||:.|..::|.|..:.:..|:. |:.::    |.||.:. .....|.:|..|||..|.:||.
Human   104 PMGGVKALTIDHLAVNDVMLESLRGEGQGLV----CDLCNDR-EVEKRCQTCKANLCHFCCQAHR 163

  Fly   502 RQRSTASHRMRSILELRRARKQKQQQMGLGDSSKLVLRCGIHTNFELKAFCTNCRQLACTDCLVI 566
            ||:.|..|.|..:.:|:          |.....|.:| |.:|...||:.||..|.:..|.||:|.
Human   164 RQKKTTYHTMVDLKDLK----------GYSRIGKPIL-CPVHPAEELRLFCEFCDRPVCQDCVVG 217

  Fly   567 LHKGHRHETISRAIGHQGKLLKEATDQTRPLCQYAEHSIERLNAIARGINDRCDDIQTQVERYMQ 631
            .|:.|..:..|..|...|..:.|....|:|..:..|.::.:::.|...:..|.:.:...|..:.:
Human   218 EHREHPCDFTSNVIHKHGDSVWELLKGTQPHVEALEEALAQIHIINSALQKRVEAVAADVRTFSE 282

  Fly   632 QYMDALTVHRKTLLQQISRARESKVEVVLKQQLDLEKRTQQAMDAVRFSQELCEIGADVEILSYV 696
            .|:.|:..||..||:|:...|..|...:..|:..||:........|.|::.|...|:|:|||...
Human   283 GYIKAIEEHRDKLLKQLEDIRAQKENSLQLQKAQLEQLLADMRTGVEFTEHLLTSGSDLEILITK 347

  Fly   697 TILLRRLEYCQQFKPPVDPKISDSLHFLPKIRAPSTKDQRDIPLYGIITMQVVEPSLCTLEWEGF 761
            .:::.||....:.:....|.::|.:.|.|:.:|...   |...:||.|..:.|:|:.|.|:.|..
Human   348 RVVVERLRKLNKVQYSTRPGVNDKIRFCPQEKAGQC---RGYEIYGTINTKEVDPAKCVLQGEDL 409

  Fly   762 SQLRLHKKADLLLHSRDADGVSLCHGGLEINCMLKYKDSSSKFLPVEVSDNRDGTYNISFTPDAQ 826
            .:.|..:.|...|..:||.|..:..||..:...:..||.....:...|.||:||||.||:||...
Human   410 HRAREKQTASFTLLCKDAAGEIMGRGGDNVQVAVVPKDKKDSPVRTMVQDNKDGTYYISYTPKEP 474

  Fly   827 GTLILTITINDRPIKGGPFTFQARQV-RPHTGIYHCCSFCSGKGNRNVMCSCEGHMP-GYSGCGH 889
            |...:.:.|.::.::|.|||...|:. |||:|::|||:|||..|.:...|:|.|.|| ||.||||
Human   475 GVYTVWVCIKEQHVQGSPFTVMVRRKHRPHSGVFHCCTFCSSGGQKTARCACGGTMPGGYLGCGH 539

  Fly   890 GHAGHPGRRHWSCCGNVLENSEC 912
            ||.||||..||||||...|.|||
Human   540 GHKGHPGHPHWSCCGKFNEKSEC 562

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG8419NP_609193.1 RING 308..>334 CDD:214546 12/25 (48%)
zf-B_box 537..576 CDD:279037 14/38 (37%)
iSH2_PI3K_IA_R 583..703 CDD:304922 28/119 (24%)
Filamin 748..846 CDD:279024 30/97 (31%)
IG_FLMN 751..849 CDD:214720 31/97 (32%)
TRIM45NP_079464.2 BBOX 189..226 CDD:237988 14/37 (38%)
iSH2_PI3K_IA_R 240..357 CDD:304922 29/116 (25%)
Filamin 394..497 32/102 (31%)
Filamin 397..494 CDD:279024 30/96 (31%)
IG_FLMN 399..497 CDD:214720 31/97 (32%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 102 1.000 Domainoid score I6887
eggNOG 1 0.900 - - E33208_3BGYU
Hieranoid 1 1.000 - -
Homologene 1 1.000 - - H11865
Inparanoid 1 1.050 292 1.000 Inparanoid score I2795
Isobase 1 0.950 - 0 Normalized mean entropy S7293
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D489543at2759
OrthoFinder 1 1.000 - - FOG0006838
OrthoInspector 1 1.000 - - oto89870
orthoMCL 1 0.900 - - OOG6_109919
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R8496
SonicParanoid 1 1.000 - - X4928
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
User_Submission 00.000 Not matched by this tool.
1413.710

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