DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG8419 and RNF208

DIOPT Version :9

Sequence 1:	NP_609193.1	Gene:	CG8419 / 34118	FlyBaseID:	FBgn0031999	Length:	921	Species:	Drosophila melanogaster
Sequence 2:	NP_001375226.1	Gene:	RNF208 / 727800	HGNCID:	25420	Length:	261	Species:	Homo sapiens

Alignment Length:	196	Identity:	53/196 - (27%)
Similarity:	77/196 - (39%)	Gaps:	51/196 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly   160 DSGSEPTSSLAGGGSSTSPESLLDNILSGASSVSVQSSSSSQASNATVAQPIKAKEQLHPKRLLS 224
            |.|.|..|...|         ||.:.|.|..                |...::|.:.:||::...
Human     4 DPGPEAGSGWPG---------LLMSCLKGPH----------------VILKMEAMKIVHPEKFPE 43

  Fly   225 LKASPELRVSP-PTPDTTQPQVQMP--TQLLLSLT---PRPEVFDAP--SPLTRSPSRSPGIS-- 279
            |.|:|....:| ||| |..|:...|  |:::::..   ..|.:..||  .||.|.|.:  |.|
Human    44 LPAAPCFPPAPRPTP-TLAPKRAWPSDTEIIVNQACGGDMPALEGAPHTPPLPRRPRK--GSSEL 105

  Fly   280 --PPVSPSPSITLR-------PSTPPENTVIFTDDLKCGICLDVYT----DPRTLHCLHSFCLQC 331
              |.|:|...:.:.       ||....::....:.|:|..|...|.    .||.|.||||.|.||
Human   106 GFPRVAPEDEVIVNQYVIRPGPSASAASSAAAGEPLECPTCGHSYNVTQRRPRVLSCLHSVCEQC 170

  Fly   332 L 332
            |
Human   171 L 171

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8419	NP_609193.1	RING	308..>334	CDD:214546	14/29 (48%)
		zf-B_box	537..576	CDD:279037
		iSH2_PI3K_IA_R	583..703	CDD:304922
		Filamin	748..846	CDD:279024
		IG_FLMN	751..849	CDD:214720
RNF208	NP_001375226.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	83..106		9/24 (38%)
RNF208	NP_001375226.1	RING-HC_RNF208	140..193	CDD:319473	15/32 (47%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D489543at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	1.010