DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG8419 and Trim71

DIOPT Version :9

Sequence 1:	NP_609193.1	Gene:	CG8419 / 34118	FlyBaseID:	FBgn0031999	Length:	921	Species:	Drosophila melanogaster
Sequence 2:	NP_001035968.1	Gene:	Trim71 / 636931	MGIID:	2685973	Length:	855	Species:	Mus musculus

Alignment Length:	692	Identity:	151/692 - (21%)
Similarity:	247/692 - (35%)	Gaps:	168/692 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly   260 EVFDAPSPLTRSPSRSPGISPPVSPSPSITLRPSTPPENTVIFTDDLKCGICLDVYTDPRTLH-- 322
            |:..:|:||:.:.|.|.. |...|.|.:....|...                      .|.||
Mouse    17 EMCGSPAPLSSNSSASSS-SSQTSTSSAGGGGPGAA----------------------ARRLHVL 58

  Fly   323 -CLHSFCLQCLVSENFKDESLWDQDQARSEEPSNYSLRSEMGGSSAELTATVSP--------ARQ 378
             |||:||..||.:                     :.|.:..|...||......|        |..
Mouse    59 PCLHAFCRPCLEA---------------------HRLPAPGGAGPAEALKLRCPVCDQKVVLAEA 102

  Fly   379 RG------SSFTLRRKKSMDRLVIRSKSDGKRSTSSIGTRFTGSFASEVSTRCIRCHTCNYPTDL 437
            .|      |:|.|  ...:|.:|..::....::..:.|.  .|......:.|    |..::|...
Mouse   103 AGMDALPSSAFLL--SNLLDAVVATAEEPPPKNGRAGGG--PGGAGGHSNHR----HHAHHPAQR 159

  Fly   438 SLGGVRQLP------QNYLLVRRIEVLRLQAGEDVISRVWCSLCTEEISATYHCISCTLNLCTLC 496
            :.....|.|      ...||:||..              .||.|.|..:|:..|:.|..:||..|
Mouse   160 AAAPAPQPPPGPAASPGSLLMRRPH--------------GCSSCDEGNAASSRCLDCQEHLCDNC 210

  Fly   497 KEAHERQRSTASHRMRSILELRR-----ARKQKQQQMGLGDS---------SKLVLRCGI---HT 544
            ..||:|.|.|..|      .:.|     |.....||:|||..         |....|.|.   |.
Mouse   211 VRAHQRVRLTKDH------YIERGPPGPAAASAAQQLGLGPPFAGAPFSILSVFPERLGFCQHHD 269

  Fly   545 NFELKAFCTNCRQLACTDCLVILHKGHRHETI------SRAIGHQGKLLKEATDQTRPLCQYAEH 603
            :..|..:|..|....|.:|.:..|.||....:      |||:..|  ||.:| .|.|   |..:.
Mouse   270 DEVLHLYCDTCSVPICRECTLGRHGGHSFAYLQDALQDSRALTIQ--LLADA-QQGR---QALQL 328

  Fly   604 SIERLNAIARGINDRCDDIQTQVERYMQQYMDALTVHRKTLLQQISRARESKVEVVLKQQLDLEK 668
            |||:...:|..:..:...:|::|:....::..||......||.::.:.|:.|.:.:..|...|.:
Mouse   329 SIEQAQTVAEQVEMKAKVVQSEVKAVTARHKKALEDRECELLWKVEKIRQVKAKSLFLQVEKLRQ 393

  Fly   669 RTQQAMDAVRFSQELCEIGADVEILSYVTILLRRLEYCQQFKPPVDPKISDSLHFLPKIRAPSTK 733
            ...:....:...|::.|.|..::||.....:|.:::..:..:..:.|:..|.:.|.|.
Mouse   394 SLSKLESTISAVQQVLEEGRALDILLARDRMLAQVQELKTIRGLLQPQEDDRIMFTPP------- 451

  Fly   734 DQRDIPLY------GIITMQVVEPSLCTLEWEGFSQLRLHKKADLLLHSRDADGVSLCHGGLEIN 792
               |..||      |.::.....| |.....:|..:....|.|...:...|.||.....||..::
Mouse   452 ---DQALYLALKSIGFVSSGAFAP-LTKATGDGIKRALQGKVASFTVMGYDHDGEPRHSGGDLMS 512

  Fly   793 CMLKYKDSSSKFLPVEVSDNRDGTYNISFTPDAQGTLILTITINDRPIKGGPFTFQARQVRPHTG 857
            .::...|.:  ....||||.::|||.:|:.|..:|..::::|:.::.|:..||....:..|.:.|
Mouse   513 VVVLGPDGN--LFGAEVSDQQNGTYIVSYRPQLEGEHLVSVTLYNQHIENSPFKVVVKSGRSYVG 575

  Fly   858 IYHCCSFCSGKGNRNVMCSCEGHMPGYS----GCGHGHAGHP 895
            |                     .:||.|    |.|.|....|
Mouse   576 I---------------------GLPGLSFGSEGDGEGKLCRP 596

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8419	NP_609193.1	RING	308..>334	CDD:214546	10/28 (36%)
		zf-B_box	537..576	CDD:279037	11/41 (27%)
		iSH2_PI3K_IA_R	583..703	CDD:304922	27/119 (23%)
		Filamin	748..846	CDD:279024	24/97 (25%)
		IG_FLMN	751..849	CDD:214720	25/97 (26%)
Trim71	NP_001035968.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	26..48		5/22 (23%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	127..177		7/55 (13%)
		zf-B_box	186..217	CDD:279037	12/30 (40%)
		zf-B_box	265..298	CDD:279037	9/32 (28%)
		iSH2_PI3K_IA_R	301..431	CDD:304922	30/135 (22%)
		Filamin	466..567		25/103 (24%)
		Filamin	469..564	CDD:279024	24/97 (25%)
		IG_FLMN	471..568	CDD:214720	25/99 (25%)
		NHL_TRIM71_like	571..855	CDD:271324	10/47 (21%)
		NHL 1	580..623		6/17 (35%)
		NHL repeat	596..635	CDD:271324	1/1 (100%)
		NHL 2	627..670
		NHL repeat	643..682	CDD:271324
		NHL 3	674..717
		NHL repeat	690..726	CDD:271324
		WD40 repeat	691..727	CDD:293791
		NHL 4	721..764
		NHL repeat	734..774	CDD:271324
		WD40 repeat	737..774	CDD:293791
		NHL 5	768..811
		WD40 repeat	782..821	CDD:293791
		NHL repeat	783..813	CDD:271324
		NHL 6	815..855
		NHL repeat	829..855	CDD:271324
		WD40 repeat	831..855	CDD:293791
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D489543at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.920