DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG8419 and trim3a

DIOPT Version :9

Sequence 1:	NP_609193.1	Gene:	CG8419 / 34118	FlyBaseID:	FBgn0031999	Length:	921	Species:	Drosophila melanogaster
Sequence 2:	XP_686295.4	Gene:	trim3a / 562489	ZFINID:	ZDB-GENE-080522-4	Length:	774	Species:	Danio rerio

Alignment Length:	660	Identity:	125/660 - (18%)
Similarity:	212/660 - (32%)	Gaps:	185/660 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly   267 PLTRSPSRSPGISPPVSPSPSITLRPSTPPENTVIFTDDLKCGICLDVYTDPRTLHCLHSFCLQC 331
            |||.:...|...||.|..                |....|.|.|||:.|.:|:.|.|||:||.:|
Zfish     2 PLTMAKRESGSTSPVVRQ----------------IDKQFLVCSICLEHYHNPKVLPCLHTFCERC 50

  Fly   332 LVSENFKDESLWDQDQARSEEPSNYSLRSEMGGSSAELTATVSPARQRGSSFTLRRKKSMDRLVI 396
            |                     .||                :.|     .|.||
Zfish    51 L---------------------QNY----------------IPP-----QSLTL----------- 62

  Fly   397 RSKSDGKRSTSSIGTRFTGSFASEVSTRCIRCHTCNYPTDLSLGGVRQLPQNYLLVRRIEVLRLQ 461
                                          .|..|...:.|...||..|..|:.:...:||  ||
Zfish    63 ------------------------------SCPVCRQTSILPEKGVAALQNNFFITNLMEV--LQ 95

  Fly   462 AGEDVISRVWCSLCTEEISATYHCISCTLNLCTLCKEAHERQRSTASHRMRSILELRRARKQKQQ 526
            ..:|                           ||         ||.||..:.|......|..
Zfish    96 REQD---------------------------CT---------RSEASSGLESAGAATYAPP---- 120

  Fly   527 QMGLGDSSKLVLRCGIHTNFELKAFCTNCRQLACTDCLVILHKGHRHETISRAIGHQGKLLKEAT 591
                       |.|..|....::.:|.:|....|.:|....|:.|....:...:......||...
Zfish   121 -----------LSCPNHEGKVMEFYCESCETAMCLECTEGEHREHVTVPLRDVLEQHKAALKNQL 174

  Fly   592 DQTRPLCQYAEHSIERLNAIARGINDRCDDIQTQVERYMQQYMDALTVHRKTLLQQISRARESKV 656
            |..|........:||.:|.|::.:.||.::..|::....::...||...:.||:..:.....:|.
Zfish   175 DAIRNRLPQLTAAIELVNEISKQLTDRKNEAVTEISNTFEELEKALHQRKTTLITDLENICSTKQ 239

  Fly   657 EVVLKQQLDLEKRTQQAMDAVRFSQELCEIGADVEILSYVTILLRRLEYCQQFKPPVDPKISDSL 721
            :|:..|...|.:..:....:..|:::....|:..|:|.....:..|:....:...|..|  .::.
Zfish   240 KVLQGQLAALMQGKENIQSSCSFTEQALNHGSPTEVLLVQKQMGERMGALARHAFPEQP--HENG 302

  Fly   722 HFLPKIRAPSTKDQRDIPLYGII--TMQVVEPSLCTLEWEGFSQLRLHKKADLLLHSRDADGVSL 784
            |...::.....:  |.|...|::  |..|...|:.|  .||.....:.:...:.:.::|.||..:
Zfish   303 HLDCQVETEGLR--RSIQNLGVLLTTSSVGHTSVAT--GEGLRHAVVGQNTTVTVTTKDKDGELV 363

  Fly   785 CHGGLEINCMLKYKDSSSKFLPVEVSDNRDGTYNISFTPDAQGTLILTITINDRPIKGGPFTFQA 849
            ..|...:...:...|..  ....:|:||::|||.|.:|..::|....::.:..|.::|.||..:|
Zfish   364 KTGNAALRAQISGADGG--VTETDVTDNKNGTYEIGYTLRSEGEFSFSVLLYGRHVRGSPFRLRA 426

  Fly   850 RQVRPHTGIYHCCSFCSGKGN-----RNVMCSCEGHMPGYSGCGHGHAGHPGRRHWSCCGNVLEN 909
            .:.            |....:     |.|      ..||..|...||......|..|...:..:.
Zfish   427 VKA------------CDAPQSPDDVKRRV------KSPGGGGGAGGHVRQKAVRRPSSMYSTTKK 473

  Fly   910 SECNVANKLL 919
            .|..:.::|:
Zfish   474 KENPIEDELI 483

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8419	NP_609193.1	RING	308..>334	CDD:214546	14/25 (56%)
		zf-B_box	537..576	CDD:279037	9/38 (24%)
		iSH2_PI3K_IA_R	583..703	CDD:304922	23/119 (19%)
		Filamin	748..846	CDD:279024	22/97 (23%)
		IG_FLMN	751..849	CDD:214720	22/97 (23%)
trim3a	XP_686295.4	RING	27..70	CDD:238093	22/125 (18%)
		BBOX	118..159	CDD:197662	10/55 (18%)
		BBC	166..291	CDD:128778	24/124 (19%)
		IG_FLMN	333..429	CDD:214720	23/99 (23%)
		Filamin	333..423	CDD:279024	21/93 (23%)
		NHL_TRIM2_like	481..774	CDD:271330	1/3 (33%)
		YncE	496..>765	CDD:225926
		NHL repeat	499..538	CDD:271330
		NHL repeat	546..585	CDD:271330
		NHL repeat	588..625	CDD:271330
		NHL repeat	632..693	CDD:271330
		NHL repeat	699..741	CDD:271330
		NHL repeat	744..770	CDD:271330
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D489543at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.920