Protein Alignment CG8419 and MEFV

DIOPT Version :10

• Sequence 1: NP_609193.1
• Gene: CG8419 / 34118
• FlyBaseID: FBgn0031999
• Length: 921
• Species: Drosophila melanogaster
• Sequence 2: NP_000234.1
• Gene: MEFV / 4210
• HGNCID: 6998
• Length: 781
• Species: Homo sapiens
• Alignment Length: 946
• Identity: 167/946 - (17%)
• Similarity: 294/946 - (31%)
• Gaps: 306/946 - (32%)

  Fly    55 KLKIKLSSAKISLRKNAQTSQNNLQTA-PLPDAVRRKSAPQLFTFTIAPKSEVTSKIHLPSVPKL 118
            |.|.||.:..:. :::::..::.:|.| |:      |.|..|.|:.   ..|...::.|..:..:
Human    23 KFKFKLQNTSVQ-KEHSRIPRSQIQRARPV------KMATLLVTYY---GEEYAVQLTLQVLRAI 77

  Fly   119 PGLAPKSSIRRSRTLGLSNSAQGAGSSGTGLSNVE-----LGVQDRDSGSEPTSSLAGGGSSTSP 178
            ........:.|:.....|....|...|....|..|     |...|...|:|.......||
Human    78 NQRLLAEELHRAAIQEYSTQENGTDDSAASSSLGENKPRSLKTPDHPEGNEGNGPRPYGG----- 137

  Fly   179 ESLLDNILSGASSVSVQSSSSSQASNATVAQPIKAKEQLHPKRLLSLKASPELRVSPPTPDTTQP 243
                     ||:|:   ..|..:|......:|: :|.:......|..:..|..| ||..|....|
Human   138 ---------GAASL---RCSQPEAGRGLSRKPL-SKRREKASEGLDAQGKPRTR-SPALPGGRSP 188

  Fly   244 ---------QVQMPTQLLLSLTPRPEVFDAPSPLTRS--------PSRSPGISPPVSPSPSITLR 291
                     |.::..:...|...|.:.....:|..:.        ||   |...|.|...:|:..
Human   189 GPCRALEGGQAEVRLRRNASSAGRLQGLAGGAPGQKECRPFEVYLPS---GKMRPRSLEVTISTG 250

  Fly   292 PSTPPENTVIFTDDLKCGICLDVYTDPRTLHCLHSFCLQCLVSENFKDESLWDQDQARSEEPSNY 356
            ...|....::.|.:.|....||..|:||                            ||.
Human   251 EKAPANPEILLTLEEKTAANLDSATEPR----------------------------ARP------ 281

  Fly   357 SLRSEMGGSSAELTATVSPARQRGSSFTLRRKKSMDRLVIRSKSDGKRSTSSIGTRFTGSFASEV 421
               :..||:||:|..  .|.....|                  ..|:...::...|........|
Human   282 ---TPDGGASADLKE--GPGNPEHS------------------VTGRPPDTAASPRCHAQEGDPV 323

  Fly   422 STRCIRCHTCNYPTDLSLGGVRQLPQNYLLVRRIEVLRLQAGEDVISRVWCSLCTEEISATYHCI 486
            ...|:| .:|::|                                          |.:|......
Human   324 DGTCVR-DSCSFP------------------------------------------EAVSGHPQAS 345

  Fly   487 SCTLNLCTLCKEAHERQRSTASHRMRSILELRRARKQKQQQMGLGDSSKLVLRCGIHTNFELKAF 551
            ......|..|:::||| :|..|...:.:.:.:|..||.|                       ..|
Human   346 GSRSPGCPRCQDSHER-KSPGSLSPQPLPQCKRHLKQVQ-----------------------LLF 386

  Fly   552 CTNCRQLACTDC-LVILHKGHR-----------HETISRAIGHQGKLLKEATDQTRPLCQYAEHS 604
            |.:..:..|..| |...|:|||           .:.|.:.:.|..||.|...:|.    .|.|..
Human   387 CEDHDEPICLICSLSQEHQGHRVRPIEEVALEHKKKIQKQLEHLKKLRKSGEEQR----SYGEEK 447

  Fly   605 ----IERLNAIARGINDRCDDIQTQVERYMQQYMDALTVHRKTLLQQISRARESKVEVVLKQQLD 665
                :::..|:.:.:..:.:.:...:|: .:.:..|.......::.||.:|.:::|    .|.:.
Human   448 AVSFLKQTEALKQRVQRKLEQVYYFLEQ-QEHFFVASLEDVGQMVGQIRKAYDTRV----SQDIA 507

  Fly   666 LEKRTQQAMDAVRFSQELCEIGADVEILSYVTILLRRLEYC---QQFKPP--VDPKISDSLHFLP 725
            |       :||:....|..|..::.|:|..:..:|.|.:..   :::..|  :..|| ..||...
Human   508 L-------LDALIGELEAKECQSEWELLQDIGDILHRAKTVPVPEKWTTPQEIKQKI-QLLHQKS 564

  Fly   726 KIRAPSTK----------DQRDIP-LYG--------IITMQVVEPSLCTLEWEGFSQLRLHKKAD 771
            :....|||          :..::| |.|        |:..:...|:|  :..:....:||..|.:
Human   565 EFVEKSTKYFSETLRSEMEMFNVPELIGAQAHAVNVILDAETAYPNL--IFSDDLKSVRLGNKWE 627

  Fly   772 LLLHSRDADGVSLCHGGLEINCMLKYKD----SSSKFLPVEVSD-------------NRDGTYNI 819
            .|     .||.....     :|::....    |..::..|||.|             :|.|  |:
Human   628 RL-----PDGPQRFD-----SCIIVLGSPSFLSGRRYWEVEVGDKTAWILGACKTSISRKG--NM 680

  Fly   820 SFTPDAQGTLILTITIND--------------RPIKG---------GPFTFQARQVRPHTGIYHC 861
            :.:|:....:::.:..|:              .|.|.         |..:|.....|.|...:..
Human   681 TLSPENGYWVVIMMKENEYQASSVPPTRLLIKEPPKRVGIFVDYRVGSISFYNVTARSHIYTFAS 745

  Fly   862 CSFCSG-----------KGNRN----VMCSCEGHMP 882
            ||| ||           .|.:|    .:|...|..|
Human   746 CSF-SGPLQPIFSPGTRDGGKNTAPLTICPVGGQGP 780

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG8419	NP_609193.1	RING_Ubox	304..>345	CDD:473075	6/40 (15%)
		Bbox1_TRIM45_C-X	470..514	CDD:380867	9/43 (21%)
		Bbox2	539..576	CDD:380814	9/48 (19%)
		CC_brat-like	583..703	CDD:475168	22/123 (18%)
		Filamin	748..846	CDD:395505	22/137 (16%)
MEFV	NP_000234.1	Pyrin_ASC-like	6..88	CDD:260033	13/74 (18%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	93..226		29/151 (19%)
		PHA03307	97..>369	CDD:223039	67/394 (17%)
		Interaction with RELA. /evidence=ECO:0000269|PubMed:18577712	266..280		6/41 (15%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	270..322		16/108 (15%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	336..373		9/37 (24%)
		Bbox2_TRIM20	373..412	CDD:380829	13/61 (21%)
		Required for homotrimerization and induction of pyroptosomes. /evidence=ECO:0000269|PubMed:17964261	420..582		33/178 (19%)
		Nuclear localization signal. /evidence=ECO:0000255	420..437		5/16 (31%)
		SPRY_PRY_TRIM20	590..773	CDD:293985	35/197 (18%)