DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG8419 and Trim2

DIOPT Version :9

Sequence 1:	NP_609193.1	Gene:	CG8419 / 34118	FlyBaseID:	FBgn0031999	Length:	921	Species:	Drosophila melanogaster
Sequence 2:	XP_038958566.1	Gene:	Trim2 / 361970	RGDID:	1310981	Length:	809	Species:	Rattus norvegicus

Alignment Length:	641	Identity:	132/641 - (20%)
Similarity:	213/641 - (33%)	Gaps:	209/641 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly   270 RSPSRSPGISPPVSPSPSITLRPSTP-PENTVIFTDDLKCGICLDVYTDPRTLHCLHSFCLQCLV 333
            |:.||:.|  |....|...:...|.| |....|....|.|.|||:.|.:|:.|.|||:||.:||
  Rat    47 RAGSRTAG--PTCQWSRMASEGASIPSPVVRQIDKQFLICSICLERYKNPKVLPCLHTFCERCL- 108

  Fly   334 SENFKDESLWDQDQARSEEPSNYSLRSEMGGSSAELTATVSPARQRGSSFTLRRKKSMDRLVIRS 398
                                .||                 .||.    |.||
  Rat   109 --------------------QNY-----------------IPAH----SLTL------------- 119

  Fly   399 KSDGKRSTSSIGTRFTGSFASEVSTRCIRCHTCNYPTDLSLGGVRQLPQNYLLVRRIEVLRL--- 460
                                        .|..|...:.|...||..|..|:.:...::||:.
  Rat   120 ----------------------------SCPVCRQTSILPEKGVAALQNNFFITNLMDVLQRTPG 156

  Fly   461 QAGED--VISRVWCSLCTEEISATYH--------CISCTLNLCTLCKEAHERQRSTASHRMRSIL 515
            ..|||  ::..|......:.:|...|        |.||...:|..|.|....:..|..  ::.::
  Rat   157 SNGEDPSILQTVTAVAAGKPLSCPNHDGNVMEFYCQSCETAMCRECTEGEHAEHPTVP--LKDVV 219

  Fly   516 ELRRARKQKQQQMGLGDSSKLVLRCGIHTNFELKAFCTNCRQLACTDCLVILHKGHRHETISRAI 580
            |..:|..|.|                                      |..::|  |...|..|:
  Rat   220 EQHKASLQVQ--------------------------------------LDAVNK--RLPEIDSAL 244

  Fly   581 GHQGKLLKEATDQTRPLCQYAEHSIERLNAIARGINDRCDDIQTQVERYMQQYMDALTVHRKTLL 645
            ....:::.:.|:|..              :|...|:...|::|           ..|.|.:..||
  Rat   245 QFISEIIHQLTNQKA--------------SIVDDIHSTFDELQ-----------KTLNVRKSVLL 284

  Fly   646 QQISRARESKVEV-------VLKQQLDLEKRTQQAMDAV-RFSQELCEIGADVEILSYVTILLRR 702
            .::        ||       ||:.|||...:.|:::.:. .|:.:....|.:.|:|.....:..:
  Rat   285 MEL--------EVNYGLKHKVLQSQLDTLLQGQESIKSCSNFTAQALNHGTETEVLLVKKQMSEK 341

  Fly   703 LEYCQQFKPPVDPKISDSLHFLPKIRAPSTKDQRDIPLYGII--TMQVVEPSLCTLEWEGFSQLR 765
            |........|:.|:.:|.|.|:  :.....|  :.|...|.|  |..|...::.|  .||..|..
  Rat   342 LNELADQDFPLHPRENDQLDFI--VETEGLK--KSIHNLGTILTTNAVASETVAT--GEGLRQTI 400

  Fly   766 LHKKADLLLHSRDADGVSLCH-GGLEINCMLKYKDSSSKFLPVEVSDNRDGTYNISFTPDAQGTL 829
            :.:...:.:.::|.|| .||. |...:...|...|.|  ....|:.||::|||...:|...:|..
  Rat   401 IGQPMSVTITTKDKDG-ELCKTGNAYLTAELSTPDGS--VADGEILDNKNGTYEFLYTVQKEGDF 462

  Fly   830 ILTITINDRPIKGGPF---TFQARQVRPHT-GIYHCCSFCSGKGNRNVMCSCEGHM 881
            .|::.:.|:.|:|.||   ..::..|.|.| |:           .|.|.....||:
  Rat   463 TLSLRLYDQHIRGSPFKLKVIRSADVSPTTEGV-----------KRRVKSPGSGHV 507

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8419	NP_609193.1	RING	308..>334	CDD:214546	14/25 (56%)
		zf-B_box	537..576	CDD:279037	3/38 (8%)
		iSH2_PI3K_IA_R	583..703	CDD:304922	22/127 (17%)
		Filamin	748..846	CDD:279024	28/101 (28%)
		IG_FLMN	751..849	CDD:214720	27/101 (27%)
Trim2	XP_038958566.1	RAD18	68..>170	CDD:227719	39/184 (21%)
		RING-HC_TRIM2	81..126	CDD:319681	24/127 (19%)
		Bbox2_TRIM2_C-VII	176..217	CDD:380882	9/42 (21%)
		BBC	222..348	CDD:128778	31/198 (16%)
		IG_FLMN	386..482	CDD:214720	27/100 (27%)
		NHL_TRIM2_like	532..809	CDD:271330
		NHL repeat	550..589	CDD:271330
		NHL repeat	597..636	CDD:271330
		NHL repeat	639..675	CDD:271330
		NHL repeat	683..727	CDD:271330
		NHL repeat	736..776	CDD:271330
		NHL repeat	779..805	CDD:271330
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D489543at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.920