Protein Alignment CG8419 and brat

DIOPT Version :10

• Sequence 1: NP_609193.1
• Gene: CG8419 / 34118
• FlyBaseID: FBgn0031999
• Length: 921
• Species: Drosophila melanogaster
• Sequence 2: NP_001188842.2
• Gene: brat / 35197
• FlyBaseID: FBgn0010300
• Length: 1061
• Species: Drosophila melanogaster
• Alignment Length: 759
• Identity: 131/759 - (17%)
• Similarity: 210/759 - (27%)
• Gaps: 298/759 - (39%)

  Fly   260 EVFDAPSPLTRSPSRSPGISPPVSPSPSITLRPSTPPENTVIFTDDLKCGICLDVYT-------- 316
            |.::....|:.||....|.|||.|.|                       .||.|.||
  Fly    20 ESYEHAGYLSDSPLTLSGSSPPASDS-----------------------AICSDEYTGGSSVKSR 61

  Fly   317 -DPRTLHCLHSFCLQCLVSENFKDESLWDQDQARSEEPSNYSLRSEMGGSSAELTATVSP---AR 377
             :...::..|........|.:....|......:.|...|:.|..|.:.|..:..::.:|.   |.
  Fly    62 SEVTVINGHHPISASVSSSSSASSSSCSSSSSSSSSSSSSSSSTSGLSGCGSTSSSVISANNVAS 126

  Fly   378 QRG--------SSFTLRRKKSMDRLVIRSKSDGKRSTSSIGTRFTGSFASEVSTRCIRCHTCNYP 434
            ..|        .|........:..||:.:   ||.|.||..:..:.:.|:....||..|.
  Fly   127 SNGPGVIGSNLQSSNNGGNSGISSLVVGA---GKGSNSSSNSSSSNTSANGSPPRCTACK----- 183

  Fly   435 TDLSLGGVRQLPQNYLLVRRIEVLRLQAGEDVISRVWCSLCTEEISATYHCISCTLNLCTLCKEA 499
                                                  |.|::.::   .|..|...||..|..|
  Fly   184 --------------------------------------SKCSDAVA---KCFECQSYLCANCVTA 207

  Fly   500 HE---------------------------------------RQRSTASHRMRSILELRRARKQKQ 525
            ||                                       :..|:.:..::...:|...::|:|
  Fly   208 HEFMHCFNGHNVCLIKGFEASTTGTPLSVGSPSNNPASNEFKYASSLTMMLQQQQQLDSQQQQQQ 272

  Fly   526 QQM----GLGDSSKLVLR-------------------------------------CGIHTNFELK 549
            ||:    .:...||:||.                                     |..|....||
  Fly   273 QQLLPAQPMSQLSKIVLAAAAQANSQEQQREDSIYGSLHPQQQQQQQQQQQRQLFCPRHKQELLK 337

  Fly   550 AFCTNCRQLACTDCLVILHKGHRHETISRAIGHQGKLLKEATDQTRPLCQYAEHSIERLNAIAR- 613
            ..|..|..|.|.:|:|:.|....||..:    .|...:..:|..|.     .|.:::.|.|..|
  Fly   338 FSCRTCCILVCKECIVLEHSTGLHELEN----VQSPGMTTSTGSTA-----NESALQTLLADMRG 393

  Fly   614 ------GINDRCDDIQTQVE-RYMQQYMDALTVHRKTLLQQISRARESKVEVVLKQQLDLEKRTQ 671
                  ||....|...|:|: :|.:.:.:....|:                 .....|| |::|:
  Fly   394 KIGEIVGIAGNSDQNLTKVKLQYQKAHNELNETHQ-----------------FFASMLD-ERKTE 440

  Fly   672 QAMDAVRFSQELCEIGADVEILSYVTILLRRLEYCQQFKPPVDPKISDSLHFLPKIRAPSTKDQ- 735
                                       ||:.||..                :..|:.:.::..|
  Fly   441 ---------------------------LLKELETL----------------YTAKVNSNNSWQQR 462

  Fly   736 -RDIPLYGIITMQVVE-----PSLCTLEWEGFSQLRLHKKADLLLHSRDADGVSLCHGGLEINCM 794
             ||:...|:.|.:.||     ||....|     .|.|.|..:..|.:    |:.......||..|
  Fly   463 SRDLIDKGLATCEAVERSPAPPSSLLTE-----ALLLRKSLEQQLQT----GIQEMQLPFEIEFM 518

  Fly   795 LKYKDSS----SKFLPVEVSDNRDGTYNISFTPDAQGTLILTITINDRPIKGGPFTFQARQVRPH 855
            ..|:...    :.|..:..:.:..|...:|.|.:..|        ...||           .||.
  Fly   519 SNYQSIQAGVRNTFGYIRANSSDGGPTGMSLTSNGHG--------KQPPI-----------ARPT 564

  Fly   856 TGIYHCCSFCSGKGNRNVMCSCEGHMPGYSGCGHGHAGHPGRRH 899
            ....:..:..:|.|:       .||  ......|||..|....|
  Fly   565 QSASNSSASSAGSGH-------HGH--HQQSHHHGHHNHHQTAH 599

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG8419	NP_609193.1	RING_Ubox	304..>345	CDD:473075	8/49 (16%)
		Bbox1_TRIM45_C-X	470..514	CDD:380867	11/82 (13%)
		Bbox2	539..576	CDD:380814	13/73 (18%)
		CC_brat-like	583..703	CDD:475168	20/127 (16%)
		Filamin	748..846	CDD:395505	21/106 (20%)
brat	NP_001188842.2	Bbox1_BRAT-like	178..222	CDD:380871	13/89 (15%)
		Bbox2_BRAT-like	326..366	CDD:380856	13/43 (30%)
		CC_brat-like	382..503	CDD:467844	32/186 (17%)
		NHL_brat_like	760..1030	CDD:271329
		NHL repeat	783..819	CDD:271329
		NHL repeat	830..871	CDD:271329
		NHL repeat	874..910	CDD:271329
		NHL repeat	914..954	CDD:271329
		NHL repeat	959..997	CDD:271329
		NHL repeat	1002..1027	CDD:271329