DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG8419 and brat

DIOPT Version :9

Sequence 1:	NP_609193.1	Gene:	CG8419 / 34118	FlyBaseID:	FBgn0031999	Length:	921	Species:	Drosophila melanogaster
Sequence 2:	NP_001188842.2	Gene:	brat / 35197	FlyBaseID:	FBgn0010300	Length:	1061	Species:	Drosophila melanogaster

Alignment Length:	759	Identity:	131/759 - (17%)
Similarity:	210/759 - (27%)	Gaps:	298/759 - (39%)

- Green bases have known domain annotations that are detailed below.

  Fly   260 EVFDAPSPLTRSPSRSPGISPPVSPSPSITLRPSTPPENTVIFTDDLKCGICLDVYT-------- 316
            |.::....|:.||....|.|||.|.|                       .||.|.||
  Fly    20 ESYEHAGYLSDSPLTLSGSSPPASDS-----------------------AICSDEYTGGSSVKSR 61

  Fly   317 -DPRTLHCLHSFCLQCLVSENFKDESLWDQDQARSEEPSNYSLRSEMGGSSAELTATVSP---AR 377
             :...::..|........|.:....|......:.|...|:.|..|.:.|..:..::.:|.   |.
  Fly    62 SEVTVINGHHPISASVSSSSSASSSSCSSSSSSSSSSSSSSSSTSGLSGCGSTSSSVISANNVAS 126

  Fly   378 QRG--------SSFTLRRKKSMDRLVIRSKSDGKRSTSSIGTRFTGSFASEVSTRCIRCHTCNYP 434
            ..|        .|........:..||:.:   ||.|.||..:..:.:.|:....||..|.
  Fly   127 SNGPGVIGSNLQSSNNGGNSGISSLVVGA---GKGSNSSSNSSSSNTSANGSPPRCTACK----- 183

  Fly   435 TDLSLGGVRQLPQNYLLVRRIEVLRLQAGEDVISRVWCSLCTEEISATYHCISCTLNLCTLCKEA 499
                                                  |.|::.::   .|..|...||..|..|
  Fly   184 --------------------------------------SKCSDAVA---KCFECQSYLCANCVTA 207

  Fly   500 HE---------------------------------------RQRSTASHRMRSILELRRARKQKQ 525
            ||                                       :..|:.:..::...:|...::|:|
  Fly   208 HEFMHCFNGHNVCLIKGFEASTTGTPLSVGSPSNNPASNEFKYASSLTMMLQQQQQLDSQQQQQQ 272

  Fly   526 QQM----GLGDSSKLVLR-------------------------------------CGIHTNFELK 549
            ||:    .:...||:||.                                     |..|....||
  Fly   273 QQLLPAQPMSQLSKIVLAAAAQANSQEQQREDSIYGSLHPQQQQQQQQQQQRQLFCPRHKQELLK 337

  Fly   550 AFCTNCRQLACTDCLVILHKGHRHETISRAIGHQGKLLKEATDQTRPLCQYAEHSIERLNAIAR- 613
            ..|..|..|.|.:|:|:.|....||..:    .|...:..:|..|.     .|.:::.|.|..|
  Fly   338 FSCRTCCILVCKECIVLEHSTGLHELEN----VQSPGMTTSTGSTA-----NESALQTLLADMRG 393

  Fly   614 ------GINDRCDDIQTQVE-RYMQQYMDALTVHRKTLLQQISRARESKVEVVLKQQLDLEKRTQ 671
                  ||....|...|:|: :|.:.:.:....|:                 .....|| |::|:
  Fly   394 KIGEIVGIAGNSDQNLTKVKLQYQKAHNELNETHQ-----------------FFASMLD-ERKTE 440

  Fly   672 QAMDAVRFSQELCEIGADVEILSYVTILLRRLEYCQQFKPPVDPKISDSLHFLPKIRAPSTKDQ- 735
                                       ||:.||..                :..|:.:.::..|
  Fly   441 ---------------------------LLKELETL----------------YTAKVNSNNSWQQR 462

  Fly   736 -RDIPLYGIITMQVVE-----PSLCTLEWEGFSQLRLHKKADLLLHSRDADGVSLCHGGLEINCM 794
             ||:...|:.|.:.||     ||....|     .|.|.|..:..|.:    |:.......||..|
  Fly   463 SRDLIDKGLATCEAVERSPAPPSSLLTE-----ALLLRKSLEQQLQT----GIQEMQLPFEIEFM 518

  Fly   795 LKYKDSS----SKFLPVEVSDNRDGTYNISFTPDAQGTLILTITINDRPIKGGPFTFQARQVRPH 855
            ..|:...    :.|..:..:.:..|...:|.|.:..|        ...||           .||.
  Fly   519 SNYQSIQAGVRNTFGYIRANSSDGGPTGMSLTSNGHG--------KQPPI-----------ARPT 564

  Fly   856 TGIYHCCSFCSGKGNRNVMCSCEGHMPGYSGCGHGHAGHPGRRH 899
            ....:..:..:|.|:       .||  ......|||..|....|
  Fly   565 QSASNSSASSAGSGH-------HGH--HQQSHHHGHHNHHQTAH 599

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8419	NP_609193.1	RING	308..>334	CDD:214546	6/34 (18%)
		zf-B_box	537..576	CDD:279037	15/75 (20%)
		iSH2_PI3K_IA_R	583..703	CDD:304922	20/127 (16%)
		Filamin	748..846	CDD:279024	21/106 (20%)
		IG_FLMN	751..849	CDD:214720	19/101 (19%)
brat	NP_001188842.2	BBOX	176..222	CDD:197662	13/91 (14%)
		zf-B_box	328..366	CDD:279037	13/41 (32%)
		NHL_brat_like	760..1030	CDD:271329
		NHL repeat	783..819	CDD:271329
		NHL repeat	830..871	CDD:271329
		NHL repeat	874..910	CDD:271329
		NHL repeat	914..954	CDD:271329
		NHL repeat	959..997	CDD:271329
		NHL repeat	1002..1027	CDD:271329
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45447033
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D489543at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	1.940