DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG8419 and trim33l

DIOPT Version :9

Sequence 1:	NP_609193.1	Gene:	CG8419 / 34118	FlyBaseID:	FBgn0031999	Length:	921	Species:	Drosophila melanogaster
Sequence 2:	XP_005158134.1	Gene:	trim33l / 327484	ZFINID:	ZDB-GENE-030131-5695	Length:	1293	Species:	Danio rerio

Alignment Length:	614	Identity:	128/614 - (20%)
Similarity:	194/614 - (31%)	Gaps:	236/614 - (38%)

- Green bases have known domain annotations that are detailed below.

  Fly   267 PLTRSPSRSPGISPPVSPSPSITLRPSTPPENTVIFTDDLKCGIC------LDVYTDPRTLHCLH 325
            |..||.|..|.:...|                         ||.|      |:..|:|:.|.|||
Zfish     6 PTGRSASPRPDLQKAV-------------------------CGTCAACKGHLNDSTEPKLLPCLH 45

  Fly   326 SFCLQCLVSENFKDESLWDQDQARSEEPSNYSLRSEMGGSSAELTATVSPARQRGSSFTLRRKKS 390
            :.|..||.                         :....|||.:..:.       ..||.|
Zfish    46 TVCNTCLT-------------------------KICTDGSSQDCPSC-------AQSFGL----- 73

  Fly   391 MDRLVIRSKSDGKRSTSSIGTRFTGSFASEVSTRCIRCHTCNYPTDLSLGGVRQLPQNYLLVRRI 455
                                        |||:       .|....|||  ...:.|:
Zfish    74 ----------------------------SEVT-------ECAIFEDLS--DNNKAPK-------- 93

  Fly   456 EVLRLQAGEDVISRVWCSLCTE-EISATYHCISCTLNLCTLCKEAHERQRSTASHRMRSILELRR 519
                            |..|.| |:|.  .|:.|...||..|..||.|.:.|..|.:
Zfish    94 ----------------CGGCEENEVSG--WCVQCEEALCLDCVTAHHRVKVTRDHEV-------- 132

  Fly   520 ARKQKQQQMGLGDSSKLVLRCGIHTNFELKAFCTNCRQLACTDCLVILHKGHRHETISRAIGHQG 584
              ..|:...|.....    ||.:|:...|:.||..|.:|.|.||.:|.|:||.......|:..|.
Zfish   133 --MPKKPPTGWIQRR----RCPLHSQESLRFFCLVCEELTCKDCQLITHRGHSFVNQEEAVESQK 191

  Fly   585 KLLKEATDQTRPLCQYAEHSIERLNAIARGINDRCDDIQTQVERYMQQYMDALTVHRKTLLQQIS 649
            :.:....|..|.......||:..|.|       |..||         :::..||  :|.|:|.:.
Zfish   192 QQMNSLLDSIRRQKGTISHSLLLLEA-------RLQDI---------EHVKMLT--KKLLIQSVH 238

  Fly   650 RARESKVEVVLKQQLDLEKRTQQAMDAVRFSQELCEIGA----DVEILSYVTILLRRLEYCQQFK 710
            :...|.|                    ::.||.|.:|.|    :|.:|......|.|||.||.:
Zfish   239 KIYHSMV--------------------LKASQILKDIQAVFAEEVRVLLERKSSLSRLEGCQDY- 282

  Fly   711 PPVDPKISDSLHFLPKIRAPSTKDQRDIPLYGIITMQV---VEPSLCTLEWEGFSQLRLH--KKA 770
                  |:|   |:.||:  .|:....:.....|..||   :....||.|    |.::||  .:.
Zfish   283 ------IAD---FIDKIQ--RTQGHCLLVYKKRIETQVKMLLSRETCTPE----SMIKLHIEIQK 332

  Fly   771 DLLLHSRDADGVSLCHGGLEINCMLKYKDSSSKFL---PVEVSDNRDGTYNISFTPDAQ------ 826
            ||..|..:...|.:...      .:.:....::::   ||.|.         |..|::.
Zfish   333 DLCQHILNFGFVRITKN------FVPFTSERTQYIQTNPVSVE---------SLNPNSMETATNV 382

  Fly   827 GTLILTITINDRPIKGGPFTFQARQVRPH 855
            |..:.:.::|:: |.|.|.|  :.|..|:
Zfish   383 GHAMASSSVNEQ-IPGDPAT--SSQTAPN 408

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8419	NP_609193.1	RING	308..>334	CDD:214546	13/31 (42%)
		zf-B_box	537..576	CDD:279037	15/38 (39%)
		iSH2_PI3K_IA_R	583..703	CDD:304922	25/123 (20%)
		Filamin	748..846	CDD:279024	21/111 (19%)
		IG_FLMN	751..849	CDD:214720	21/108 (19%)
trim33l	XP_005158134.1	zf-RING_UBOX	25..65	CDD:290181	14/64 (22%)
		BBOX	90..132	CDD:197662	16/67 (24%)
		zf-B_box	143..182	CDD:279037	15/42 (36%)
		PHD_TIF1_like	1071..1113	CDD:277016
		Bromodomain	1133..1228	CDD:295360
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910