DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG8419 and Trim32

DIOPT Version :9

Sequence 1:	NP_609193.1	Gene:	CG8419 / 34118	FlyBaseID:	FBgn0031999	Length:	921	Species:	Drosophila melanogaster
Sequence 2:	NP_001012103.1	Gene:	Trim32 / 313264	RGDID:	1305238	Length:	655	Species:	Rattus norvegicus

Alignment Length:	651	Identity:	124/651 - (19%)
Similarity:	206/651 - (31%)	Gaps:	201/651 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly   306 LKCGICLDVYTD----PRTLHCLHSFCLQCLVSENFKDESLWDQDQARSEEPSNYSLRSEMGGSS 366
            |:|.||::.:|:    |:.|||.|:.|.|||       |.|               |.|.:.|
  Rat    19 LECPICMESFTEEQLRPKLLHCGHTICRQCL-------EKL---------------LASSING-- 59

  Fly   367 AELTATVSPARQRGSSFTLRRKKSMDRLVIRSKSDGKRSTSSIGTRFTGSFASEVSTRCIRCHTC 431
                                                                       :||..|
  Rat    60 -----------------------------------------------------------VRCPFC 65

  Fly   432 NYPTDLSLGGVRQLPQNYLLVRRIEVLRLQAGEDVISRVWCSLCTEEISATYHCISCTLNLCTLC 496
            :..|.::  .:.||..|..:::.|:...|   .:.:..:.|..|...:...: |.||.|.||..|
  Rat    66 SKITRIT--SLTQLTDNLTVLKIIDTAGL---SEAVGLLMCRACGRRLPRQF-CRSCGLVLCEPC 124

  Fly   497 ---------------KEAHERQRSTASHRMRSILEL-----RRARKQKQQQMGLGDSSKLVLRCG 541
                           |||.|.:|.....::..:.||     ||....:.....|....|.||:..
  Rat   125 READHQPPGHCTLPVKEAAEERRRDFGEKLTRLRELTGELQRRKAALEGVSRDLQARYKAVLQEY 189

  Fly   542 IHTNFELKAFCTNCRQLACTDCLVILHKGHRHETISRAIGHQGKLLKEATDQTRPLCQYAEHSIE 606
            .|....::......|:. .|..|..:.|.:     |:.:..|..||..|..|....|.|....|:
  Rat   190 GHEERRVQEELARSRKF-FTGSLAEVEKSN-----SQVVEEQSYLLNIAEVQAVSRCDYFLAKIK 248

  Fly   607 RLNAIARGINDRCDDIQTQVERYMQQYMDALTVHRKTLLQQISRARESKVEVVLKQQLDLEKRTQ 671
            :.:...  :.:..|:.:.::         ..::.|:..||.:...:...|..:...|...:.||.
  Rat   249 QADVAL--LEETADEEEPEL---------TASLPRELTLQDVELLKVGHVGPLQIGQAVKKPRTV 302

  Fly   672 QAMD--AVRFSQELCEIGADVEILSYVTILLRRLEYCQQFKPPVDPKISDSLH------------ 722
            ...|  ||       |.||.....:.||  .|.::...:...| .|:.|.:..
  Rat   303 NMEDSWAV-------EEGAASSASASVT--FREMDMSPEEVVP-SPRASPAKQRSSEAASSIQQC 357

  Fly   723 -FLPKIRAP-STKDQRDIPLYGIITMQVVEPSLCTLEWEGFSQLRLHKKADLLLHSR-------- 777
             ||.|:.|. ||....::|    :::.|...|...:...|..::::..:...|...|
  Rat   358 LFLKKMGAKGSTPGMFNLP----VSLYVTSQSEVLVADRGNYRIQVFNRKGFLKEIRRSPSGIDS 418

  Fly   778 ------DADGVSLCHGGLEINC--MLKYKDSSSKFLPVEVSDNR---------DGTYNISFTPDA 825
                  .||..:|....:.:||  ::...||....|.|...|..         ...:.|:..|..
  Rat   419 FVLSFLGADLPNLTPLSVAMNCHGLIGVTDSYDNSLKVYTLDGHCVACHRSQLSKPWGITALPSG 483

  Fly   826 QGTLILTITINDRPIKGGP---FTFQARQVRPHTGIYHCCSFCSGKGNRNVMCSCEGHMPGYSGC 887
            |      ..:.|  ::||.   ||     |....|:......||....:.|.|..||.:....|.
  Rat   484 Q------FVVTD--VEGGKLWCFT-----VDRGAGVVKYSCLCSAVRPKFVTCDAEGTVYFTQGL 535

  Fly   888 G 888
            |
  Rat   536 G 536

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8419	NP_609193.1	RING	308..>334	CDD:214546	13/29 (45%)
		zf-B_box	537..576	CDD:279037	7/38 (18%)
		iSH2_PI3K_IA_R	583..703	CDD:304922	25/121 (21%)
		Filamin	748..846	CDD:279024	21/125 (17%)
		IG_FLMN	751..849	CDD:214720	22/125 (18%)
Trim32	NP_001012103.1	RING-HC_TRIM32_C-VII	20..66	CDD:319501	20/128 (16%)
		Bbox1_TRIM32_C-VII	99..139	CDD:380864	9/40 (23%)
		NHL_TRIM32_like	364..646	CDD:271331	37/190 (19%)
		NHL repeat	376..416	CDD:271331	6/43 (14%)
		NHL repeat	433..472	CDD:271331	7/38 (18%)
		NHL repeat	474..514	CDD:271331	10/52 (19%)
		NHL repeat	515..566	CDD:271331	6/22 (27%)
		NHL repeat	579..611	CDD:271331
		NHL repeat	619..645	CDD:271331
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D489543at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.010