DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG8419 and TRIM2

DIOPT Version :9

Sequence 1:	NP_609193.1	Gene:	CG8419 / 34118	FlyBaseID:	FBgn0031999	Length:	921	Species:	Drosophila melanogaster
Sequence 2:	NP_001362417.1	Gene:	TRIM2 / 23321	HGNCID:	15974	Length:	802	Species:	Homo sapiens

Alignment Length:	644	Identity:	137/644 - (21%)
Similarity:	229/644 - (35%)	Gaps:	184/644 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly   270 RSPSRSPGISPPVSPSPSITLRPSTP-PENTVIFTDDLKCGICLDVYTDPRTLHCLHSFCLQCLV 333
            |:.|::.|  ||...|...:...:.| |....|....|.|.|||:.|.:|:.|.|||:||.:||
Human    13 RAGSKTAG--PPCQWSRMASEGTNIPSPVVRQIDKQFLICSICLERYKNPKVLPCLHTFCERCL- 74

  Fly   334 SENFKDESLWDQDQARSEEPSNYSLRSEMGGSSAELTATVSPARQRGSSFTLRRKKSMDRLVIRS 398
                                .||                 .||.    |.||
Human    75 --------------------QNY-----------------IPAH----SLTL------------- 85

  Fly   399 KSDGKRSTSSIGTRFTGSFASEVSTRCIRCHTCNYPTDLSLGGVRQLPQNYLLVRRIEVLRLQAG 463
                                        .|..|...:.|...||..|..|:.:...::||:...|
Human    86 ----------------------------SCPVCRQTSILPEKGVAALQNNFFITNLMDVLQRTPG 122

  Fly   464 EDVISRVWCSLCTEEISATYHCISCTLNLCTLCKEAHERQRSTASH--RMRSILELRRARKQKQQ 526
            .:          .||.|.          |.|:...|..:..|..:|  ..:|...:.|.......
Human   123 SN----------AEESSI----------LETVTAVAAGKPLSCPNHDGNRQSFAVVPRLVSNPWP 167

  Fly   527 QMGLGDSSKLVLRCGIHTNFELKAFCTNCRQLACTDCLVILHKGHRHETISRAIGHQGKLLKEAT 591
            |:.|......||  |:..   ::.:|.:|....|.:|....|.  .|.|:.         ||:..
Human   168 QVILPPWPSKVL--GLQV---MEFYCQSCETAMCRECTEGEHA--EHPTVP---------LKDVV 216

  Fly   592 DQTRPLCQYAEHSIERLNAIARGINDRCDDIQTQVERYMQQYMDALTVHRKTL----------LQ 646
            :|.:...|.      :|:|    :|.|..:|.:.:: ::.:.:..||..:.::          ||
Human   217 EQHKASLQV------QLDA----VNKRLPEIDSALQ-FISEIIHQLTNQKASIVDDIHSTFDELQ 270

  Fly   647 QISRARES----KVEV-------VLKQQLDLEKRTQQAMDAV-RFSQELCEIGADVEILSYVTIL 699
            :....|:|    ::||       ||:.|||...:.|:::.:. .|:.:....|.:.|:|.....:
Human   271 KTLNVRKSVLLMELEVNYGLKHKVLQSQLDTLLQGQESIKSCSNFTAQALNHGTETEVLLVKKQM 335

  Fly   700 LRRLEYCQQFKPPVDPKISDSLHFLPKIRAPSTKDQRDIPLYGII--TMQVVEPSLCTLEWEGFS 762
            ..:|........|:.|:.:|.|.|:  :.....|  :.|...|.|  |..|...::.|  .||..
Human   336 SEKLNELADQDFPLHPRENDQLDFI--VETEGLK--KSIHNLGTILTTNAVASETVAT--GEGLR 394

  Fly   763 QLRLHKKADLLLHSRDADGVSLCH-GGLEINCMLKYKDSSSKFLPVEVSDNRDGTYNISFTPDAQ 826
            |..:.:...:.:.::|.|| .||. |...:...|...|.|  ....|:.||::|||...:|...:
Human   395 QTIIGQPMSVTITTKDKDG-ELCKTGNAYLTAELSTPDGS--VADGEILDNKNGTYEFLYTVQKE 456

  Fly   827 GTLILTITINDRPIKGGPF---TFQARQVRPHT-GIYHCCSFCSGKGNRNVMCSCEGHM 881
            |...|::.:.|:.|:|.||   ..::..|.|.| |:           .|.|.....||:
Human   457 GDFTLSLRLYDQHIRGSPFKLKVIRSADVSPTTEGV-----------KRRVKSPGSGHV 504

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8419	NP_609193.1	RING	308..>334	CDD:214546	14/25 (56%)
		zf-B_box	537..576	CDD:279037	9/38 (24%)
		iSH2_PI3K_IA_R	583..703	CDD:304922	27/141 (19%)
		Filamin	748..846	CDD:279024	28/101 (28%)
		IG_FLMN	751..849	CDD:214720	27/101 (27%)
TRIM2	NP_001362417.1	RAD18	33..>136	CDD:227719	40/205 (20%)
		RING-HC_TRIM2	47..92	CDD:319681	24/127 (19%)
		Bbox_SF	142..214	CDD:381767	17/87 (20%)
		BBC	219..345	CDD:128778	25/136 (18%)
		IG_FLMN	383..479	CDD:214720	27/100 (27%)
		NHL_TRIM2_like	529..802	CDD:271330
		NHL repeat	547..586	CDD:271330
		NHL repeat	594..633	CDD:271330
		NHL repeat	636..672	CDD:271330
		NHL repeat	680..720	CDD:271330
		NHL repeat	729..769	CDD:271330
		NHL repeat	772..798	CDD:271330
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D489543at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.920