Protein Alignment CG8419 and Trim28

DIOPT Version :10

• Sequence 1: NP_609193.1
• Gene: CG8419 / 34118
• FlyBaseID: FBgn0031999
• Length: 921
• Species: Drosophila melanogaster
• Sequence 2: NP_035718.2
• Gene: Trim28 / 21849
• MGIID: 109274
• Length: 834
• Species: Mus musculus
• Alignment Length: 471
• Identity: 102/471 - (21%)
• Similarity: 166/471 - (35%)
• Gaps: 119/471 - (25%)

  Fly   264 APSPLTRSPSRSPGIS-----PPVSPSPSITLRPSTPPENTVIFTDDLK-CGIC---LDVYTDPR 319
            |.|..:.||....|.:     |..|.:.:.:...|:|........:.|: ||:|   |....|||
Mouse    16 AASAASGSPGSGEGSAGGEKRPAASSAAAASAAASSPAGGGGEAQELLEHCGVCRERLRPERDPR 80

  Fly   320 TLHCLHSFCLQCLVSENFKDESLWDQDQARSEEPSNYSLRSEMGGSSAELTATVSPARQRGSSFT 384
            .|.||||.|..||.                                    .||.:.|...|...:
Mouse    81 LLPCLHSACSACLG------------------------------------PATPAAANNSGDGGS 109

  Fly   385 LRRKKSMDRLVIRSKSDGKRSTSSIGTRFTGSFASEVSTRCIRCHTCNYPTDLSLGGVRQLPQNY 449
            ......:|..|.:.:...|....:...|.:||.||..|....:|
Mouse   110 AGDGAMVDCPVCKQQCYSKDIVENYFMRDSGSKASSDSQDANQC--------------------- 153

  Fly   450 LLVRRIEVLRLQAGEDVISRVWCSLCTEEISATYHCISCTLNLCTLCKEAHERQRSTASHRMRSI 514
                                  |:.|.:...||.:|:.|:..||..|.|||:|.:.|..|.:||.
Mouse   154 ----------------------CTSCEDNAPATSYCVECSEPLCETCVEAHQRVKYTKDHTVRST 196

  Fly   515 LELRRARKQKQQQMGLGDSSKLVLRCGIHTNFELKAFCTNCRQLACTDCLVILHKGHRHETISRA 579
            ...:..           |..:.|. |.:|.:..|..||.:|..|.|.||.:..||.|:::.:..|
Mouse   197 GPAKTR-----------DGERTVY-CNVHKHEPLVLFCESCDTLTCRDCQLNAHKDHQYQFLEDA 249

  Fly   580 IGHQGKLL----KEATDQTRPLCQYAEHSIERLNAIARGINDRCDDIQTQVERYMQQYMDALTVH 640
            :.:|.|||    |...|:...|    :.:.:.:.:..|.::|....:|..|:..:.|.|..|...
Mouse   250 VRNQRKLLASLVKRLGDKHATL----QKNTKEVRSSIRQVSDVQKRVQVDVKMAILQIMKELNKR 310

  Fly   641 RKTLLQQISRARESKVEVVLKQQLDLEKRTQQAMDAVRFSQELCEIGADVEILSYVTILLRRLEY 705
            .:.|:....:..|.:.|.:.:|...:.|..:.....:||:....|...:..:|     |.::|.|
Mouse   311 GRVLVNDAQKVTEGQQERLERQHWTMTKIQKHQEHILRFASWALESDNNTALL-----LSKKLIY 370

  Fly   706 CQQFK------PPVDP 715
            .|..:      .||:|
Mouse   371 FQLHRALKMIVDPVEP 386

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG8419	NP_609193.1	RING_Ubox	304..>345	CDD:473075	16/44 (36%)
		Bbox1_TRIM45_C-X	470..514	CDD:380867	16/43 (37%)
		Bbox2	539..576	CDD:380814	13/36 (36%)
		CC_brat-like	583..703	CDD:475168	24/123 (20%)
		Filamin	748..846	CDD:395505
Trim28	NP_035718.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	13..56		9/39 (23%)
		RING-HC_TIF1beta	63..125	CDD:438421	22/97 (23%)
		Bbox1_TIF1b_C-VI	149..200	CDD:380904	18/93 (19%)
		Bbox2_TIF1b_C-VI	207..250	CDD:380887	14/43 (33%)
		Leucine zipper alpha helical coiled-coil region	247..377		28/138 (20%)
		Interaction with MAGEC2. /evidence=ECO:0000250	248..377		28/137 (20%)
		BBC	253..379	CDD:128778	27/134 (20%)
		Involved in binding PPP1CA. /evidence=ECO:0000250	367..371		1/3 (33%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	412..480
		HP1 box	476..513
		PxVxL motif	481..494
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	581..602
		PHD_TIF1beta	627..669	CDD:277093
		Bromodomain	696..802	CDD:445827