Protein Alignment CG8419 and madd-2

DIOPT Version :9

• Sequence 1: NP_609193.1
• Gene: CG8419 / 34118
• FlyBaseID: FBgn0031999
• Length: 921
• Species: Drosophila melanogaster
• Sequence 2: NP_503395.1
• Gene: madd-2 / 178619
• WormBaseID: WBGene00016539
• Length: 765
• Species: Caenorhabditis elegans
• Alignment Length: 527
• Identity: 113/527 - (21%)
• Similarity: 215/527 - (40%)
• Gaps: 111/527 - (21%)

  Fly   304 DDLKCGICLDVYTDPRTLHCLHSFCLQCLVSENFKDESLWDQDQARSEEPSNYSLRSEMGGSSAE 368
            ::|||.||:..:.||..|.|.||.|..|.:..:....|. ......|..||...:.|::..|::.
 Worm     3 EELKCTICIRFFEDPIILTCGHSLCRMCALKAHQPSTSS-GSSSTSSPRPSTPGILSQILSSASS 66

  Fly   369 LTATVSPARQRGSSFTL------RRKKSMDRLVIRSKSDG--------KRSTSSIG---TRFTGS 416
            ..:..|.....|:|.|:      ......|:|.:.|::|.        .|.:|.||   :|....
 Worm    67 PISPQSAGSSSGASDTMSLCVSDNGDHESDKLSVVSETDSGVVGCGRTSRPSSIIGPPLSRLHNI 131

  Fly   417 FASEVSTRCIRCHTC-------------NYPTDLSLGGVRQLPQNYLLVRRIEVL---------- 458
            .....|...:.|::|             :.||:|::   :.:.:.|||....:..
 Worm   132 LTPSTSGVQLVCNSCQKPSYFCDENSIVSAPTNLAM---QNVIRRYLLAHPDKAFLTPSCSGSSG 193

  Fly   459 ---RLQAGEDVISRVWCSLC--TEEISATYHCISCTLNLCTLCKEA-HERQRSTASHRMRSILEL 517
               ..|:.::..|:  |.||  :|...|...|..|.:..||.|:.| |..:...|.|   ::|:.
 Worm   194 SSGSSQSSDEASSQ--CQLCEGSENRMANVFCEQCDIYYCTPCQTALHPARGPLAKH---NLLQA 253

  Fly   518 RRARKQKQQQMGLGDSSKLVLRCGIHTNFELKAFCTNCRQLACTDCLVIL-HKGHRHETISRAI- 580
            ....::|...:....:.:.:|||..|....|..:|..|:...|:.||..| |..|..:::..|.
 Worm   254 NDGERKKSSAITTATTVRDLLRCATHPGEGLTMYCLACKVPVCSRCLQDLRHANHDVQSLPIACK 318

  Fly   581 GHQGKL---LKEATDQTRPLCQYAEHSIERLNAIARGINDRCDDIQTQVERYMQQYMDALTVHRK 642
            ||:.:|   |::.:::.:.    |...|.||..:...:.:.|:|.::.:...:.|.::.|.:.::
 Worm   319 GHKTELSTTLQQLSEKAKT----ATEEIGRLKGLHDVVKNNCNDFKSSLCIQIDQLIEQLQMRKE 379

  Fly   643 TLLQQISRARESKVEVVLKQQLDLEKRTQQAMDAVRFSQELCEIGADVEILSYVTILLRRLEYC- 706
            .|:|.:....::| ..:||.|:            |:.:.:|.:..|             .:::|
 Worm   380 KLMQHVDEQADNK-RRILKSQI------------VKCTGKLTKTSA-------------LIQFCI 418

  Fly   707 QQFKPPVDPKI-----------SDSLHFL--PKIRAPSTKDQRDIPLYGIITMQVVEPSLCTLEW 758
            :..|.| ||.:           |.||.||  .::|   ||.:.|......:..:.::.::.||:
 Worm   419 EALKEP-DPTVYMQISNALLHRSTSLEFLWHKEMR---TKPETDSEFVLNLDTKHLQYTIQTLD- 478

  Fly   759 EGFSQLR 765
              |:||:
 Worm   479 --FAQLK 483

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG8419	NP_609193.1	RING	308..>334	CDD:214546	11/25 (44%)
		zf-B_box	537..576	CDD:279037	13/39 (33%)
		iSH2_PI3K_IA_R	583..703	CDD:304922	19/122 (16%)
		Filamin	748..846	CDD:279024	5/18 (28%)
		IG_FLMN	751..849	CDD:214720	5/15 (33%)
madd-2	NP_503395.1	RING	7..>33	CDD:214546	11/25 (44%)
		zf-B_box	271..313	CDD:279037	13/41 (32%)
		BBC	320..445	CDD:128778	28/155 (18%)
		FN3	499..590	CDD:238020
		SPRY_PRY_TRIM67_9	587..763	CDD:293947

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910