Protein Alignment CG8419 and nhl-1

DIOPT Version :9

• Sequence 1: NP_609193.1
• Gene: CG8419 / 34118
• FlyBaseID: FBgn0031999
• Length: 921
• Species: Drosophila melanogaster
• Sequence 2: NP_499028.1
• Gene: nhl-1 / 176295
• WormBaseID: WBGene00003597
• Length: 974
• Species: Caenorhabditis elegans
• Alignment Length: 561
• Identity: 101/561 - (18%)
• Similarity: 173/561 - (30%)
• Gaps: 208/561 - (37%)

  Fly   253 LSLTPRPEVFDAPSPLTRSPSRSPGISPPVSPSPSITLRPSTPPENTVIFTDDLKCGICLDVYTD 317
            :|.:|:.|. :|...:....||.|      |..|:..:.|....|..      |.|.||||.|..
 Worm     1 MSSSPQNEA-EAREKMRELMSRPP------SSRPADFVNPLEKIEQL------LTCPICLDRYKQ 52

  Fly   318 PRTLHCLHSFCLQCLVSENFKDESLWDQDQARSEEPSNYSLRSEMGGSSAELTATVSPARQRGSS 382
            |:.|.|.|:||..||       ||..|
 Worm    53 PKLLPCQHTFCYPCL-------ESCAD-------------------------------------- 72

  Fly   383 FTLRRKKSMDRLVIRSKSDGKRSTSSIGTRFTGSFASEVSTRCIRCHTCNYPTDLSLGGVRQLPQ 447
             ||.|.                                     ::|..|....::...||:....
 Worm    73 -TLHRN-------------------------------------LKCPECRAEHNIPYDGVKAFQP 99

  Fly   448 NYLLVRRIEVLRLQAGEDVISRVWCSLCTEEISATYHCISCTLNLCTLCKEAHERQRSTASHRMR 512
            ||.|...:|: .|||..:..:.:      ||....|:     |..|.:|.|..:.:.
 Worm   100 NYTLTGFLEI-HLQATPESAAEI------EEYIHRYN-----LERCKICDEKADCEP-------- 144

  Fly   513 SILELRRARKQKQQQMGLGDSSKLVLRCGIHTNFELKAFCTNCRQLACTDCLVILHKGHRHETIS 577
                                                   |.:|.:.||.:|         .:|
 Worm   145 ---------------------------------------CAHCDRKACKEC---------RQT-- 159

  Fly   578 RAIGHQGKLLKEATDQTRPLCQYAEHSIERLNAIARGIN---DRCDDIQTQVERYMQQYMDALTV 639
                |...|.::.:.....:.:.|....|..:.:::|::   ..|:..:.:::.|..:|...|..
 Worm   160 ----HMDMLKRDMSRLLNQVKRLANRITEASDNLSKGVDMMTMNCETTKAEIKEYFHRYQRDLKK 220

  Fly   640 HRKTLLQQIS--RARESKVEVVLKQQLDLEKRTQ----QAMDAVRFSQELCEIGADVEILSYVTI 698
            .....|.::.  :|.|::....|:..|::|....    ..:||....:  |.| .|.|::.....
 Worm   221 KEDNFLMEVDTFQATETRNMSNLRDVLEIESSNMSEAVSRLDAAIKGE--CSI-EDSELVRMKNT 282

  Fly   699 LLRRLEYCQQFKPPVDPKISDSLHF--------LPKIRAPSTKDQ----------RDIPLYGIIT 745
            ....|||.:.|:|..|...:..|.|        ||  .|.:|..:          |.:||.   .
 Worm   283 FTEGLEYLRNFQPDADELFNRKLRFSAGDDAAKLP--AAITTSGELCVLVPQFSGRYLPLE---Q 342

  Fly   746 MQVVEPSLCTLEWEGFSQLRLHKKADLLLHSRDADGVSLCH 786
            ..:..|....||.:.: :::..::|.  :..|:||..|..|
 Worm   343 SYLPRPFRLPLESDSY-RVKSDERAS--MRDREADRTSSRH 380

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG8419	NP_609193.1	RING	308..>334	CDD:214546	14/25 (56%)
		zf-B_box	537..576	CDD:279037	5/38 (13%)
		iSH2_PI3K_IA_R	583..703	CDD:304922	20/128 (16%)
		Filamin	748..846	CDD:279024	9/39 (23%)
		IG_FLMN	751..849	CDD:214720	9/36 (25%)
nhl-1	NP_499028.1	zf-C3HC4	43..83	CDD:278524	21/122 (17%)
		FRQ	<426..545	CDD:286504
		NHL_TRIM71_like	691..974	CDD:271324
		NHL repeat	715..754	CDD:271324
		YncE	721..>973	CDD:225926
		NHL repeat	762..800	CDD:271324
		NHL repeat	808..844	CDD:271324
		NHL repeat	852..893	CDD:271324
		NHL repeat	902..932	CDD:271324
		NHL repeat	948..974	CDD:271324

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D489543at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.920