Protein Alignment CG8419 and lin-41

DIOPT Version :9

• Sequence 1: NP_609193.1
• Gene: CG8419 / 34118
• FlyBaseID: FBgn0031999
• Length: 921
• Species: Drosophila melanogaster
• Sequence 2: NP_001020998.1
• Gene: lin-41 / 172760
• WormBaseID: WBGene00003026
• Length: 1147
• Species: Caenorhabditis elegans
• Alignment Length: 1010
• Identity: 191/1010 - (18%)
• Similarity: 318/1010 - (31%)
• Gaps: 380/1010 - (37%)

  Fly   140 QGAGSSGTGLSNVELGVQDRDSGSEPTSSLAGGGSSTSPESLLDNILSGASSVSVQSSSSSQASN 204
            :|| .||......|:.|...|||:|    |:.||||:..:|:                |..:..:
 Worm    13 EGA-PSGPRRLQTEIDVDANDSGNE----LSMGGSSSEGDSM----------------SHHRGEH 56

  Fly   205 ATVAQPIKAKEQLHPKRLLSLKASPELRVSPPTPDTTQPQVQMPTQLLLSLTPRPEVFDAPSPLT 269
            :    |....:..|            |...||.|..|                 ..:||.|..:.
 Worm    57 S----PNHHHQDNH------------LGSGPPPPQFT-----------------GSLFDTPPSMI 88

  Fly   270 RSPSRSP--------GISPPVSPSPSITLRPSTPPENTVIFTDDLKCGICLDVYTDPRTLH---- 322
            :||.:.|        |:..|                     .|..:|.:|    :...|:.
 Worm    89 QSPQQQPQFQFNTGFGLGLP---------------------QDSFRCSVC----SKSSTIGVLPF 128

  Fly   323 -CLHSFCLQCLVSENFKDESLWDQDQARSEEPSNYSLRS-EMGGSSAELTATVS---------PA 376
             |.|..|..|.                 ...||:|..|: ::.|:.:..||..:         |:
 Worm   129 VCAHKTCQSCY-----------------QMTPSSYDRRACKLCGAVSTATANFTSQMYLSPTLPS 176

  Fly   377 RQRGS--------------------------SFTLRRKKSMDRLVIRSKSDGKRSTSSIG----- 410
            ..||:                          ||:|.........|:     |.|..||.|
 Worm   177 PPRGALMSDCSTPTMNNHINSSTPLHQPRAFSFSLSGMPGSPSPVM-----GARMPSSAGGLMMR 236

  Fly   411 -TRFTGSFASEVSTRCIRCHTCNYPTDL------SLGGVRQLPQNYLLVRRI------------- 455
             ..|..|.:|..|...::     .|:.|      |:||.:|  |:.:|::.:
 Worm   237 PIGFPDSDSSLTSWSPLQ-----QPSQLSINNLSSIGGHQQ--QSPMLMQNVFDSLAVNDDTPVF 294

  Fly   456 -------------------------------------EVLRLQAGEDVISR-------------- 469
                                                 ...|||....:.|:
 Worm   295 SPLSPTNTSMHMPPSLMASPDVPKHSATIAPPRNSMCSTPRLQLATPMSSQSQQTFPIPSPLGSQ 359

  Fly   470 ---------VWCSLCTEEISATYHCISCTLNLCTLCKEAHERQRSTASH------RMRSILELRR 519
                     :.|..|..:||..| |:.|...||..|.:||:|.|:|..|      ::.:.|..|.
 Worm   360 PQQQQPMGPIQCQGCESKISFAY-CMQCQEALCIHCVQAHQRVRATKQHAFVELQQLMATLMSRA 423

  Fly   520 ARKQKQQQ----------------------------------MGLGDSS-KLVLRCGIHTNFELK 549
            .:.|:.||                                  :|.|:|| :....||.|.:. :.
 Worm   424 VQPQQAQQYTQNVGGSVRQALGSVGSGDVFFSGHVSGVENDSIGSGESSPRSSSVCGTHDSV-II 487

  Fly   550 AFCTNCRQ--LACTDCLVILHKG-HRHE---TISRAIGHQGKLLKEATDQTRPLCQYAEHSIERL 608
            ..|.||..  |.|..| |..|.| ||.:   .|..|:|       |..::::.|....|.:.:.:
 Worm   488 GICENCPHSVLLCAIC-VAQHPGKHRVQPLGDIRVAVG-------EVVNESQLLQWQCEKTGDTI 544

  Fly   609 NAIARGINDRCDDIQTQVERYMQQYMDALTVHRKTLLQQISRARESKVEVVLKQQLDLEKRTQQA 673
            ..|..||.......:.::......:::||...||.||:::...:..|:.|::.|...|:.:....
 Worm   545 KQIIDGIVTNATTAENEIRAAFDTHVNALEERRKELLKRVETVKNLKLSVLISQAESLQSKQIDL 609

  Fly   674 MDAVRFSQELCEIG-ADVEILSYVTILLRRLEYCQQFKPPVDPKISDSLHFLPKIRAPSTKDQR- 736
            ..|::.:.:|.:.. .|..:|..|   ..:|..||......:|. ::.|:.| .:.....:|.|
 Worm   610 QQAIQTATKLMDSSDCDEMVLRQV---FEKLASCQMGNEGTEPN-NNILNVL-MLACQVNEDDRL 669

  Fly   737 --DIPLYGIITMQV-----VEPSLC----TLEWEGFSQLRLHKKADLLLHSRDADGVSLC----- 785
              ..|..||:..:.     :|...|    ::..:.|.:....::..:.:..|||.|..|.
 Worm   670 KFTAPQDGILLNKARQFGNIESGPCAKNSSIVGDSFKKAIRERQTVIYVQLRDACGDLLSSSIAA 734

  Fly   786 --------------HGGLE-------INCMLKYKDSSSKFLPVEVSDNRDGTYNISFTPDAQGTL 829
                          |..||       :...:...|.|:  :.|.::...:|...:|:.|..:|:.
 Worm   735 TQPTSQALLPHQEPHSHLEQAMPTSDVQAFVISPDGST--VEVTMTPRENGIVALSYYPSIEGSY 797

  Fly   830 ILTITINDRPIKGGPFTFQARQVRPHTGIYHCCSFCSGKGNRNVMCSCEGHMP----GYSGCGHG 890
            .|.|.:...||.|.|.|...|:.|.:..|       :.||            |    |..|.|.|
 Worm   798 TLNILVKGTPISGCPTTMDIRRGRNYDEI-------AAKG------------PILTFGKEGSGDG 843

  Fly   891 HAGHPGRRHWSCC----GNVL----ENSECNVANK 917
            ....|    |..|    |.|:    .|:...:.:|
 Worm   844 ELCRP----WGICVDQRGRVIVADRSNNRVQIFDK 874

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG8419	NP_609193.1	RING	308..>334	CDD:214546	7/30 (23%)
		zf-B_box	537..576	CDD:279037	14/44 (32%)
		iSH2_PI3K_IA_R	583..703	CDD:304922	21/120 (18%)
		Filamin	748..846	CDD:279024	24/132 (18%)
		IG_FLMN	751..849	CDD:214720	24/127 (19%)
lin-41	NP_001020998.1	BBOX	478..516	CDD:197662	14/39 (36%)
		BBC	519..645	CDD:128778	27/135 (20%)
		Filamin	693..812	CDD:279024	22/120 (18%)
		NHL_TRIM71_like	823..1147	CDD:271324	15/75 (20%)
		YncE	847..1144	CDD:225926	7/32 (22%)
		NHL repeat	848..887	CDD:271324	7/31 (23%)
		NHL repeat	895..934	CDD:271324
		NHL repeat	942..978	CDD:271324
		NHL repeat	987..1028	CDD:271324
		NHL repeat	1037..1067	CDD:271324
		NHL repeat	1121..1147	CDD:271324

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D489543at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.920