Protein Alignment CG8419 and MID2

DIOPT Version :10

• Sequence 1: NP_609193.1
• Gene: CG8419 / 34118
• FlyBaseID: FBgn0031999
• Length: 921
• Species: Drosophila melanogaster
• Sequence 2: NP_036348.2
• Gene: MID2 / 11043
• HGNCID: 7096
• Length: 735
• Species: Homo sapiens
• Alignment Length: 713
• Identity: 135/713 - (18%)
• Similarity: 242/713 - (33%)
• Gaps: 236/713 - (33%)

  Fly   305 DLKCGICLDVYTDPRTLHCLHSFCLQC----LVSENFKDESLWDQDQARSEEPSNYSLRSEMGGS 365
            :|.|.|||:::.||..|.|.||.|..|    |||.....||:         ||
Human    27 ELTCPICLELFEDPLLLPCAHSLCFSCAHRILVSSCSSGESI---------EP------------ 70

  Fly   366 SAELTATVSPARQRGSSFTLRRKKSMDRLVIRSKSDGKRSTSSIGTRFTGSFASEVSTRCIRCHT 430
               :||                                                      .:|.|
Human    71 ---ITA------------------------------------------------------FQCPT 78

  Fly   431 CNYPTDLSLGGVRQLPQNYLLVRRIEVLRLQ----AGEDVIS-----------------RVWCSL 474
            |.|...|:..|:..|.:|..|...|:  |.|    :|.:..|                 |:.|..
Human    79 CRYVISLNHRGLDGLKRNVTLQNIID--RFQKASVSGPNSPSESRRERTYRPTTAMSSERIACQF 141

  Fly   475 CTEE--ISATYHCISCTLNLCTLCKEA-HERQRSTASHRMRSILELRRARKQKQQQMGLGDSSKL 536
            |.::  ..|...||:|.::.|..|..| |..::...|||:..               .:.|:...
Human   142 CEQDPPRDAVKTCITCEVSYCDRCLRATHPNKKPFTSHRLVE---------------PVPDTHLR 191

  Fly   537 VLRCGIHTNFELKAFCTNCRQLACTDC-LVILHKGHR-----------HETISRAIGHQGKLLKE 589
            .:.|..|.|.::..:|.:..||.|..| ||..|:.|:           .:|:...:.:..|...|
Human   192 GITCLDHENEKVNMYCVSDDQLICALCKLVGRHRDHQVASLNDRFEKLKQTLEMNLTNLVKRNSE 256

  Fly   590 ATDQTRPL---CQYAEHSIERLNAIARGINDRCDD----IQTQVERYMQQYMDALTVHRKTLLQQ 647
            ..:|...|   ||..|.:.....|   .:.:.||:    ||.:.:....:..:...:..:.|.||
Human   257 LENQMAKLIQICQQVEVNTAMHEA---KLMEECDELVEIIQQRKQMIAVKIKETKVMKLRKLAQQ 318

  Fly   648 ISRARE--SKVEVVLKQQLDLEKRTQQAMDAVRFSQELCEIGADVEILSYVT-ILLRRLEYCQQF 709
            ::..|:  .:..|::.|...:.|...||    ||.|....|...|.:.:..: :|:..:.:...|
Human   319 VANCRQCLERSTVLINQAEHILKENDQA----RFLQSAKNIAERVAMATASSQVLIPDINFNDAF 379

  Fly   710 KP-----PVDPKISDSLHFLPKIRAPSTKDQRDIPLYGIITMQVV---EPSLCTLE--------- 757
            :.     ..:.|:.:.|.:|.....||.:::.....:..||:..:   |.|:.:.|
Human   380 ENFALDFSREKKLLEGLDYLTAPNPPSIREELCTASHDTITVHWISDDEFSISSYELQYTIFTGQ 444

  Fly   758 ----------WEGFSQLRLHKKADL----------LLHSRDA----DGVSLCH---GGLEINCML 795
                      |..:.::|..|:|..          |.:|.|:    ..:...|   .||:
Human   445 ANFISKSWCSWGLWPEIRKCKEAVSCSRLAGAPRGLYNSVDSWMIVPNIKQNHYTVHGLQ----- 504

  Fly   796 KYKDSSSKFLPVEVSDNRDGTYNISFTPDAQGTLILTITINDRPIKGGPFTFQARQVRPHTGIYH 860
                |.::::.:..:.|:.|:.|      ::.|.:.|   |.:|.|..|.....:....:.|:
Human   505 ----SGTRYIFIVKAINQAGSRN------SEPTRLKT---NSQPFKLDPKMTHKKLKISNDGL-- 554

  Fly   861 CCSFCSGKGNRNVMCSCEGHMP-GYSGCG-HGHAGHPGRRHWSCCGNVLENSECNVANKLLNS 921
                   :..::.....:.|.| .:||.| :|.|           ||:..:|.|:....::.|
Human   555 -------QMEKDESSLKKSHTPERFSGTGCYGAA-----------GNIFIDSGCHYWEVVMGS 599

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG8419	NP_609193.1	RING_Ubox	304..>345	CDD:473075	18/43 (42%)
		Bbox1_TRIM45_C-X	470..514	CDD:380867	13/46 (28%)
		Bbox2	539..576	CDD:380814	12/48 (25%)
		CC_brat-like	583..703	CDD:475168	27/129 (21%)
		Filamin	748..846	CDD:395505	23/136 (17%)
MID2	NP_036348.2	RING-HC_MID2	21..90	CDD:438412	27/140 (19%)
		Bbox1_MID2_C-I	135..187	CDD:380895	14/66 (21%)
		Bbox2_MID2_C-I	193..232	CDD:380881	12/38 (32%)
		BBC	239..364	CDD:128778	27/131 (21%)
		COS	343..394	CDD:465805	10/54 (19%)
		FN3	401..531	CDD:238020	22/144 (15%)
		SPRY_PRY_TRIM1	536..705	CDD:293974	15/84 (18%)