DRSC/TRiP Functional Genomics Resources

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Protein Alignment CG8419 and TRIM3

DIOPT Version :9

Sequence 1:NP_609193.1 Gene:CG8419 / 34118 FlyBaseID:FBgn0031999 Length:921 Species:Drosophila melanogaster
Sequence 2:NP_001234935.1 Gene:TRIM3 / 10612 HGNCID:10064 Length:744 Species:Homo sapiens


Alignment Length:580 Identity:122/580 - (21%)
Similarity:204/580 - (35%) Gaps:178/580 - (30%)


- Green bases have known domain annotations that are detailed below.


  Fly   291 RPSTP-PENTVIFTDDLKCGICLDVYTDPRTLHCLHSFCLQCLVSENFKDESLWDQDQARSEEPS 354
            |..:| ||...:....|.|.||||.|..|:.|.|||:||.:||                     .
Human     4 REDSPGPEVQPMDKQFLVCSICLDRYQCPKVLPCLHTFCERCL---------------------Q 47

  Fly   355 NYSLRSEMGGSSAELTATVSPARQRGSSFTLRRKKSMDRLVIRSKSDGKRSTSSIGTRFTGSFAS 419
            ||                 .||:    |.||                                  
Human    48 NY-----------------IPAQ----SLTL---------------------------------- 57

  Fly   420 EVSTRCIRCHTCNYPTDLSLGGVRQLPQNYLLVRRIEVLRLQA------GED------VISRVWC 472
                   .|..|...:.|...||..|..|:.:...:|.:: ||      .||      |..|...
Human    58 -------SCPVCRQTSILPEQGVSALQNNFFISSLMEAMQ-QAPDGAHDPEDPHPLSVVAGRPLS 114

  Fly   473 SLCTEEISATYHCISCTLNLCTLCKEAHERQRSTASHRMRSILELRRARKQKQQQMGLGDSSKLV 537
            ....|..:..::|.:|...:|..|:....|:..|.  .:|.::|..:|..|:|.:...|      
Human   115 CPNHEGKTMEFYCEACETAMCGECRAGEHREHGTV--LLRDVVEQHKAALQRQLEAVRG------ 171

  Fly   538 LRCGIHTNFELKAFCTNCRQLACTDCLVILHKGHRHETISRAIGHQGKLLKEATDQTRPLCQYAE 602
                                              |...:|.||...|.:.:          |..|
Human   172 ----------------------------------RLPQLSAAIALVGGISQ----------QLQE 192

  Fly   603 HSIERLNAIARGINDRCDDIQTQVERYMQQYMDALTVHRKTLLQQISRARESKVEVVLKQQLDLE 667
            ...|.|..|:....|        :|:.:||...||.    :.|:.|..|::.    ||:.|||..
Human   193 RKAEALAQISAAFED--------LEQALQQRKQALV----SDLETICGAKQK----VLQSQLDTL 241

  Fly   668 KRTQQAM-DAVRFSQELCEIGADVEILSYVTILLRRLEYCQQFKPPVDPKISDSLHFLPKIRAPS 731
            ::.|:.: .:..|:::...:|:..|:|.....:..||........|..|..:..|..:.::... 
Human   242 RQGQEHIGSSCSFAEQALRLGSAPEVLLVRKHMRERLAALAAQAFPERPHENAQLELVLEVDGL- 305

  Fly   732 TKDQRDIPLYG--IITMQVVEPSLCTLEWEGFSQLRLHKKADLLLHSRDADGVSLCHGGLEINCM 794
               :|.:...|  :.|......::.|  .||..|..:.:.|.|.:.::|.||..:..|..|:...
Human   306 ---RRSVLNLGALLTTSATAHETVAT--GEGLRQALVGQPASLTVTTKDKDGRLVRTGSAELRAE 365

  Fly   795 LKYKDSSSKFLPVEVSDNRDGTYNISFTPDAQGTLILTITINDRPIKGGPFTFQARQVRP 854
            :...|.:.  |||.|.|:::|||.:.:|...:|.|:|::.:..:|::|.|  |:.|.:||
Human   366 ITGPDGTR--LPVPVVDHKNGTYELVYTARTEGELLLSVLLYGQPVRGSP--FRVRALRP 421

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG8419NP_609193.1 RING 308..>334 CDD:214546 15/25 (60%)
zf-B_box 537..576 CDD:279037 1/38 (3%)
iSH2_PI3K_IA_R 583..703 CDD:304922 25/120 (21%)
Filamin 748..846 CDD:279024 27/97 (28%)
IG_FLMN 751..849 CDD:214720 28/97 (29%)
TRIM3NP_001234935.1 Interaction with KIF21B. /evidence=ECO:0000250|UniProtKB:Q9R1R2 2..290 86/437 (20%)
RING-HC_TRIM3 19..63 CDD:319682 24/126 (19%)
RING-HC finger (C3HC4-type) 22..62 CDD:319682 23/122 (19%)
BBOX 110..151 CDD:197662 8/42 (19%)
BBC 158..284 CDD:128778 35/191 (18%)
Filamin 317..418 29/106 (27%)
IG_FLMN 322..419 CDD:214720 29/102 (28%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 419..464 2/3 (67%)
NHL_TRIM2_like 471..744 CDD:271330
NHL 1 473..516
NHL repeat 489..528 CDD:271330
NHL 2 520..563
NHL repeat 536..575 CDD:271330
NHL 3 564..605
NHL repeat 578..615 CDD:271330
NHL 4 609..652
NHL repeat 622..663 CDD:271330
NHL 5 656..699
NHL repeat 669..711 CDD:271330
NHL 6 700..743
NHL repeat 714..740 CDD:271330
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D489543at2759
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.920

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